Sorimachi Hiroyuki

• 2008 - 酵母からヒトまで保存されたカルパインの生理機能の研究
• 2005 - プロテアーゼ・プロテオミクス
• 1995 - コネクチンの生理機能解析
• 1988 - 組織特異的カルパインの生理機能に関する研究
• Protease Proteomics
Physiological functions of connectin-titin
Study on physiological functions of tissue-specific calpain.

• Yasuko Ono, Takaomi C. Saido, Hiroyuki Sorimachi. Calpain research for drug discovery: challenges and potential. NATURE REVIEWS DRUG DISCOVERY. 2016. 15. 12. 854-876
• Takuro Miyazaki, Kazuo Tonami, Shoji Hata, Toshihiro Aiuchi, Koji Ohnishi, Xiao-Feng Lei, Joo-ri Kim-Kaneyama, Motohiro Takeya, Hiroyuki Itabe, Hiroyuki Sorimachi, et al. Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing. JOURNAL OF CLINICAL INVESTIGATION. 2016. 126. 9. 3417-3432
• Fumiko Shinkai-Ouchi, Suguru Koyama, Yasuko Ono, Shoji Hata, Koichi Ojima, Mayumi Shindo, David duVerle, Mika Ueno, Fujiko Kitamura, Naoko Doi, et al. Predictions of Cleavability of Calpain Proteolysis by Quantitative Structure-Activity Relationship Analysis Using Newly Determined Cleavage Sites and Catalytic Efficiencies of an Oligopeptide Array. MOLECULAR & CELLULAR PROTEOMICS. 2016. 15. 4. 1262-1280
• Yasuko Ono, Koichi Ojima, Fumiko Shinkai-Ouchi, Shoji Hata, Hiroyuki Sorimachi. An eccentric calpain, CAPN3/p94/calpain-3. BIOCHIMIE. 2016. 122. 169-187
• Yasuko Ono, Hiroyuki Sorimachi. Amino acid sequence alignment of vertebrate CAPN3/calpain-3/p94. Data in Brief. 2015. 5. 366-367

ｍore...

• 免疫の反逆
  三田出版 1997

• カルパインのミスセンス変異体を発現する遺伝子改変マウスの作出とその解析
  2001 - 2008
• An integrated approach to the molecular functions of titin and nebulin.
  1997 - 2000

• - 1988 The University of Tokyo Graduate School of Science Department of Biochemistry
• - 1988 The University of Tokyo Graduate School, Division of Science
• - 1986 The University of Tokyo Faculty of Science
• - 1986 The University of Tokyo Faculty of Science

• Ph.D. (The University of Tokyo)
• M.Sc. (The University of Tokyo)

• 日本病態プロテアーゼ学会 評議員
• ASBMB, American Society for Biochemistry and Molecular Biology Regular member
• ASBMB, American Society for Biochemistry and Molecular Biology Regular member

• 1999 - 日本生化学会奨励賞
• 1999 - Young Investigator Award (The Japanese Biochemical Society)

日本病態プロテアーゼ学会 ,  World Muscle Society ,  蛋白質科学会 ,  細胞生物学会 ,  American Society for Biochemistry and Molecular Biology ,  ASBMB ,  International Proteolysis Society ,  IPS ,  農芸化学会 ,  生化学会 ,  分子生物学会 ,  Japan Society for Protein Science ,  Japan Society for Cell Biology ,  The Molecular Biology Society of Japan ,  The Japanese Biochemical Society ,  American Society for Biochemistry and Molecular Biology ,  ASBMB ,  International Proteolysis Society ,  IPS