Toshihiko Torigoe

• 微小重力環境の細胞生物学
• 神経筋変性疾患の病態形成における分子シャペロンの役割
• ストレス蛋白質による免疫制御
• 免疫系による腫瘍拒絶機構の解明と癌免疫治療の開発

• Jun Kasamatsu, Shojiro Takahashi, Masahiro Azuma, Misako Matsumoto, Akiko Morii-Sakai, Masahiro Imamura, Takanori Teshima, Akari Takahashi, Yoshihiko Hirohashi, Toshihiko Torigoe, et al. PolyI:C and mouse survivin artificially embedding human 2B peptide induce a CD4+T cell response to autologous survivin in HLA-A*2402 transgenic mice. IMMUNOBIOLOGY. 2015. 220. 1. 74-82
• Daichi Ota, Masashi Kanayama, Yutaka Matsui, Koyu Ito, Naoyoshi Maeda, Goro Kutomi, Koichi Hirata, Toshihiko Torigoe, Noriyuki Sato, Akinori Takaoka, et al. Tumor-α9β1 integrin-mediated signaling induces breast cancer growth and lymphatic metastasis via the recruitment of cancer-associated fibroblasts. Journal of molecular medicine (Berlin, Germany). 2014. 92. 12. 1271-81
• Tomohide Tsukahara, Makoto Emori, Kenji Murata, Takahisa Hirano, Norihiro Muroi, Masanori Kyono, Shingo Toji, Kazue Watanabe, Toshihiko Torigoe, Vitaly Kochin, et al. Specific Targeting of a Naturally Presented Osteosarcoma Antigen, Papillomavirus Binding Factor Peptide, Using an Artificial Monoclonal Antibody. JOURNAL OF BIOLOGICAL CHEMISTRY. 2014. 289. 32. 22035-22047
• Toshiaki Tanaka, Toshihiko Torigoe, Yoshihiko Hirohashi, Eiji Sato, Ichiya Honma, Hiroshi Kitamura, Naoya Masumori, Taiji Tsukamoto, Noriyuki Sato. Hypoxia-inducible factor (HIF)-independent expression mechanism and novel function of HIF prolyl hydroxylase-3 in renal cell carcinoma. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY. 2014. 140. 3. 503-513
• Jerome Galon, Bernhard Mlecnik, Gabriela Bindea, Helen K. Angell, Anne Berger, Christine Lagorce, Alessandro Lugli, Inti Zlobec, Arndt Hartmann, Carlo Bifulco, et al. Towards the introduction of the 'Immunoscore' in the classification of malignant tumours. JOURNAL OF PATHOLOGY. 2014. 232. 2. 199-209

ｍore...

• A Yagihashi, K Asanuma, D Kobayashi, N Tsuji, Y Shijubo, S Abe, Y Hirohashi, T Torigoe, N Sato, N Watanabe. Detection of autoantibodies to livin and survivin in Sera from lung cancer patients. LUNG CANCER. 2005. 48. 2. 217-221
• A potent immunogenic general cancer vaccine that targets survivin, an inhibitor of apoptosis proteins. Clin Cancer Res. 2005. 11. 1474-82
• S Kawaguchi, T Wada, K Ida, Y Sato, S Nagoya, T Tsukahara, S Kimura, H Sahara, H Ikeda, K Shimozawa, et al. Phase I vaccination trial of SYT-SSX junction peptide in patients with disseminated synovial sarcoma. JOURNAL OF TRANSLATIONAL MEDICINE. 2005. 3. 1-9
• N Kondo, S Ichimiya, Y Tamura, A Tonooka, S Koshiba, T Torigoe, K Kamiguchi, K Takenaga, N Sato. A calcium binding protein, S100A4, mediates T cell dependent cytotoxicity as a transformation-associated antigen. MICROBIOLOGY AND IMMUNOLOGY. 2005. 49. 1. 49-56
• Aberrant expression and potency as a cancer immunotherapy target of inhibitor of apoptosis protein family, Livin/ML-IAP in lung cancer. Clin Cancer Res. 2005. 11. 1000-9

ｍore...

• - 1984 National Defense Medical College
• - 1984 National Defense Medical College

• M.D., Ph.D.

• 2014 - Ono Cancer Research Foundation Research Grant
• 2014 - NOASTEC Foundation Research and Development Grant
• 2007/10 - The Japanese Society of Pathology Academic Research Award
• 2002 - 大阪癌研究会研究助成
• 2002 - Osaka Cancer Research Foundation
2000 - 日本宇宙フォーラム地上研究助成
2000 - Japan Space Forum Ground Research
1999 - 秋山記念生命科学振興財団
1999 - Akiyama Foundation
1997 - 伊藤医薬学術交流財団
1997 - Itoh Foundation

日本宇宙生物学会 ,  日本内科学会 ,  国際細胞ストレス学会 ,  米国癌学会 ,  日本免疫学会評議員 ,  日本病理学会評議員 ,  日本癌学会 ,  Japanese Society for Biological Sciences in Space ,  Japanese Society of Internal Medicine ,  Cell Stress Society International ,  American Association for Cancer Research ,  The Japanese Society for Immunology ,  The Japanese Society of Pathology ,  The Japanese Cancer Association