2016 - 2018 Development of innovative nucleic acid medicine for gastroenterological cancer
2015 - 2018 Evaluation of hepatotoxicity of oligonucleotide therapeutics
2015 - 2017 Development of chip device to detect methylations on microRNAs
2015 - 2017 New construction of in vivo reprogramming technology by modified microRNA
2014 - 2017 New construction of innovative drug discovery foundation technology for refractory gastrointestinal cancer targeting cancer metabolomics
2014 - 2016 Development of liver cancer treatment using Vasohibin-2 targeting antisense oligonucleotide
2013 - 2016 Creation of xenonucleic acid switch molecules
2012 - 2016 Development of platform technologies for antisense oligonucleotide-based therapeutics by a combination of nucleic acids chemistry and information sciences
2012 - 2016 Developing a novel treatment and primary prevention for age-related macular degeneration based on disease mechanisms
2013 - 2015 The identification of long-noncoding RNAs associated with the formation of atherosclerotic plaques and their therapeutic manipulation strategy
2013 - 2015 A novel anti-inflammatory strategy by targeting endothelial cell-specific receptor, Robo4
2013 - 2015 Evaluation of Off-target Effects of Antisense Oligonucleotides
2012 - 2015 Synthesis of novel fluorescent compounds possessing a ON/OFF switching system, and their application to fluorescent probes
2011 - 2013 Electrochemical regulation of nucleic acids hybridization
2011 - 2012 Regulation of RNA Splicing by BNA Antisense Oligonucleotides
2011 - 2012 Development of a novel nucleic acid drug targeting sense/antisense transcript pairs
2009 - 2011 Development of oligonucleotide-based artificial transcription factor based on the higher-order structure of nucleic acids
2008 - 2009 遺伝子発現の時空間制御を目的とした外部刺激応答性スイッチの開発
2007 - 2008 A novel approach for cancer prevention by artificial transcription factor based on peptide engineering
2006 - 2007 Control of Gene Expression by Functional and Artificial Nucleic Acids
2004 - 2005 先進的ポストゲノム基盤技術開発に向けた機能性人工核酸の創製
2003 - 2003 がんの遺伝子治療に向けた超機能性人工オリゴヌクレオチドの創製
2000 - 2002 Study to develop novel genomic drugs by using superfunctional oligonucleotide analogues
2001 - 2001 がんの遺伝子治療に向けた超機能性人工オリゴヌクレオチドの創製
2001 - 2001 標的遺伝子の自在な発現制御を可能とする人工オリゴヌクレオチドの開発
2000 - 2001 超効率的遺伝子発現制御に向けた人工核酸類の創製
1999 - 2001 Design and Syntheses of Biologically Functional Molecules Based on the Mechanisms of Life
2000 - 2000 がんの遺伝子治療に向けた超機能性人工オリゴヌクレオチドの創製
1999 - 2000 超機能性合成オリゴヌクレオチドによる特定遺伝子の転写制御法の開発
1997 - 1999 Development of highly functional medicines targeting genomic DNA/RNA
1997 - 1998 標的mRNAを特異的に切断するアンチセンス分子の合成と機能
1996 - 1996 アンチセンス法を指向した新規な核酸類縁体の合成とその機能評価
1995 - 1995 生物活性を有するアミン類の新しい不斉合成法の開発研究
1993 - 1993 キラルなNADHモデル化合物を用いた共役redox系の開発研究
カチオン性リポソームを用いた遺伝子導入法の開発
新規なアンチセンスオリゴヌクレオチドの合成とその機能評価
キラルなNADHモデル化合物の合成研究
Studies on Gene Transfer with Cationic Liposomes
Synthesis and Property of Novel Antisense Oligomucleotides
Synthesis of Chiral NADH Model Compunds
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Papers (291)：
Satoshi Obika, Takashi Osawa, Ryota Nakasishi. Synthesis and structural analysis of dinucleotides containing 2′,3′-trans-bridged nucleic acids (2′,3′-trans-BNAs) with trans-5,6- or 5,7-fused ring skeleton. 2024
Takashi Osawa, Ryosuke Kita, Yuuya Kasahara, Harumi Yamaguma, Taisuke Nakayama, Haruhiko Kamada, Satoshi Obika. In vitro screening of chemically synthesized dipeptide-antisense oligonucleotide conjugates to identify ligand molecules enhancing their activity. Bioorganic and Medicinal Chemistry. 2024. 110. 117814-117814
Shogo Omuro, Takao Yamaguchi, Taiji Kawase, Kenji Hirose, Tokuyuki Yoshida, Takao Inoue, Satoshi Obika. Separation and Characterization of Therapeutic Oligonucleotide Isomer Impurities by Cyclic Ion Mobility Mass Spectrometry. Journal of the American Society for Mass Spectrometry. 2024
廣瀬賢治, 吉田徳幸, 寺崎真樹, 瀬崎浩史, 唐澤薫, 岩崎了教, 高原健太郎, 滝口直美, 関口光明, 南海浩一, et al. Comparison of Analysis Data of Model Oligonucleotide Therapeutics Obtained with Different Types of Liquid Chromatograph-Mass Spectrometers. 医薬品医療機器レギュラトリーサイエンス. 2023. 54. 5
松林泰毅, 吉岡耕太郎, MON Su Su Lei, JIA Chunyan, 原倫太朗, 永田哲也, 中川治, 中川治, 小比賀聡, 横田隆徳. Development of antisense oligonucleotides with a new base-chemical modification. 日本核酸医薬学会年会講演要旨集(CD-ROM). 2022. 7th
田中佑弥, 谷奥有里花, 阿曽古都美, 中山泰亮, 鎌田春彦, 山口卓男, 小比賀聡. Synthesis and evaluation of lipid-modified antisense oligonucleotides. 日本薬学会年会要旨集(Web). 2021. 141st
大澤昂志, 小比賀聡. Chemistry in oligonucleotide medicines. Bio Clinica. 2021. 36. 14
菅原眞歩, 田中真悠, 田中陸, 飯居宏美, 高木寛子, 谷口恵香, 笠原勇矢, 笠原勇矢, 小比賀聡, 小比賀聡, et al. gamma-Glutamyl cycrotransferase antisense oligonucleotide induces cell cycle arrest and apoptosis in A549 lung cancer cells. 日本薬学会年会要旨集(CD-ROM). 2020. 140th
Nucleic Acids Therapeutics Society of Japan
, 日本ケミカルバイオロジー学会
, The American Association for the Advancement of Science
, Nucleotides and Nucleic Acids
, International Society for Nucleosides
, アンチセスDNA/RNA研究会
, 日本化学会
, 日本薬学会
, The American Association for the Advancement of Science
, Nucleotides and Nucleic Acids
, International Society for Nucleosides
