Uesato Shinichi

ウエサトシンイチ | Uesato Shinichi

Affiliation and department：
Research theme for competitive and other funds (12)：

2012 - 2016 The role and mechanisms of TORC and HDAC signaling pathway and therapeutic new-class small compounds for neurological disease
2010 - 2012 Targeting the ERK-MAP kinase pathway in cancer therapy
2009 - 2011 Development of cationic histone deacetylase inhibitors as enhancer of gene transfection and expression
2007 - 2009 Attempted synthesis of taxol utilizing anti-taxol monoclonal antibody as a as a chiral mould
2007 - 2008 Synthesis of Histone Deacetylase Inhibitors Toward the Development of DDS

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Papers (117)：

Hiroshi Tawarayama, Yoshiyuki Hirata, Keiko Uchida, Noriko Himori, Shinichi Uesato, Toru Nakazawa. Isozyme-specific histone deacetylase 1/2 inhibitor K560 attenuates oxidative stress-induced retinal cell death. Neuroscience letters. 2023. 793. 136978-136978
Haomin Yan, Tsutomu Sasaki, Hideaki Kanki, Yoshiyuki Hirata, Kumiko Nishiyama, Sunao Hisada, Shigenobu Matsumura, Yasuo Nagaoka, Takaaki Sumiyoshi, Seiichi Nagano, et al. MDMX elevation by a novel Mdmx-p53 interaction inhibitor mitigates neuronal damage after ischemic stroke. Scientific reports. 2022. 12. 1. 21110-21110
Yoshiyuki Hirata, Hinata Nishino, Tsutomu Sasaki, Yasuo Nagaoka, Shinichi Uesato, Masahiko Taniguchi. Sirtuin inhibition and neurite outgrowth effect as new biological activities for Areca catechu nut alkaloids. Phytomedicine Plus. 2022. 2. 3
Hinata Nishino, Yoshiyuki Hirata, Yasuo Nagaoka, Shinichi Uesato. [Isoform Selectivity of HDAC Inhibitors Has a Significant Effect on PD-L1 Expression in the Triple-negative Cancer Cell Line MDA-MB-231]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2022. 142. 4. 431-437
Li See Kwan, Shu Ying Tan, Yoshiyuki Hirata, Lai-Keng Chan, Yasuo Nagaoka, Shinichi Uesato, Peng Lim Boey. Biotic elicitation at different feeding time in cell suspension cultures of Eurycoma longifolia Jack, a valuable medicinal plant, for enhancement of cytotoxic activity of bioactive compounds against human colon cancer cell line. In Vitro Cellular & Developmental Biology - Plant. 2021

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MISC (33)：

平田佳之, 浅田耀平, 西野陽向, 木村耕介, 佐々木勉, 長岡康夫, 上里新一, 上里新一, 谷口雅彦. Alkaloids from Picrasma quassioides as the modulator of autophagy. 日本薬学会年会要旨集(Web). 2022. 142nd
平田佳之, 浅田耀平, 山口耕介, 佐々木勉, 長岡康夫, 上里新一, 谷口雅彦. ニガキ由来アルカロイドのrotenone誘発性SHSY5Y細胞死に対する細胞保護効果. 日本生薬学会年会講演要旨集. 2022. 68th
平田佳之, 上里新一, 松井大亮. Development of a handy screening method of histone deacetylase 1 inhibitor using an amide compound library constructed by a one-pot chemoenzymatic synthesis. 日本生物工学会大会講演要旨集. 2021. 73rd
平田佳之, 佐々木勉, 上里新一, 上里新一, 長岡康夫, 芝野真喜雄, 谷口雅彦. Identifcation of nerve growth factors with chemical pulldown by arecaidine from Areca catechu. 日本薬学会年会要旨集(CD-ROM). 2020. 140th (Web)
木村耕介, 平田佳之, 光高蓉平, 佐々木勉, 長岡康夫, 上里新一, 上里新一, 芝野真喜雄, 谷口雅彦. ニガキ由来アルカロイドpicrasidine Lのヒト神経芽腫細胞株SHSY5Yに対するオートファジー誘導効果. 日本生薬学会年会講演要旨集. 2019. 66th

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Patents (7)：

神経変性疾患治療薬のスクリーニング方法
p53-mdmx相互作用を阻害する低分子抗がん剤
抗インフルエンザウイルス剤,
アシルアミノフェニル基を有する抗がん剤
カルボキサミド誘導体

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Books (17)：

バイオテクノロジーの医薬品への応用とその展望について
関西大学工業技術研究所技苑 1999
Conformational Analysis of Febrifugines and Halofuginones in Organic Solvents Chem. Pharm. Bull., 46 (1)
1998
Fungal Metabolites.X. The Effect of Peptide Antibiotics, Trichosporin-Bs, on the Respiratory Activity of Mitochondria Biol. Pharm. Bull., 17 (4)
1994
Fungal Metabolites. Part 6. Nuclear Magnetic Resonance Study of Antibiotic Peptides, Trichosporin Bs, from Trichoderma polysporum J. Chem. Soc. Perkin Trans. 1
1993
Stereospecificity of Hydrogen Transfer by NADP-Linked Acyclic Monoterpene Primary Alchohol Dehydrogenase Phytochemistry, 30 (7)
1991

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Lectures and oral presentations (61)：

食品バイオマスバナナ外果皮からの抗がん活性成分の探索
(2014)
p53-mdmx結合を選択的に阻害する低分子化合物K-178の創製とこれを基盤とする構造最適化
(2014)
p53-mdmx相互作用を阻害する低分子抗がん化合物の構造活性相関
(2013)
p53-Mdmx結合阻害低分子化合物の創製と構造活性相関:がん細胞に対する細胞毒性と作用機作の評価
(2013)
HDAC1/2-selective inhibitor K-560 exhibited a cytostatic anticancer activity
(2013)

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Works (34)：

抗インフルエンザウイルス剤
2008 -
アシルアミノフェニル基を有する抗がん剤
2008 -
遺伝子発現増強剤およびそれを用いた遺伝子発現増強法
2008 -
Building an International Network Exchange Program of Education and Research for Graduate Course Students in Life and Biotechnology
2008 -
(-)-Eepigallocatechin-3-gallate and (-)-epigallocatechin inhibit herigulin b1-induced migration/invasion of MCF-7 breast carcinoma cell line
2007 -

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Education (2)：

- 1975 Kyoto University
- 1970 Kyoto University Faculty of Pharmaceutical Sciences

Work history (2)：

Kansai University Faculty of Chemistry ,Materials and Bioengineering, Department of Life Science and Biotechnology
昭和51年10月1日-昭和63年3月31日:京都大学薬学部助手、昭和55年9月1日-昭和56年8月31日:米国カリフォルニア大学サンディエゴ分校E. Wenkert教授のもとに留学、昭和61年6月1日-昭和61年8月31日:文部省在外研究員としてドイツ連邦共和国ミュンヘン大学でM.H. Zenk教授と共同研究、平成5年9月1日-平成8年6月30日:日本たばこ産業株式会社医薬総合研究所化学研究所副所長、平成9年4月1日関西大学工学部教授。

Association Membership(s) (1)：

日本薬学会

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