Rchr

J-GLOBAL ID：200901040860445840 Update date: Aug. 30, 2023

Higuchi Masaya

ヒグチマサヤ | Higuchi Masaya

Affiliation and department：

Research keywords (1)： HTLV-1, Ubiquitin, Deubiquitinase, Hematopoietic stem cells

Research theme for competitive and other funds (3)：

2021 - 2021 脱ユビキチン化酵素基質分子の新規同定法の開発
2018 - 2020 脱ユビキチン化酵素USP10が司る造血幹細胞維持機構の解明
2015 - 2017 脱ユビキチン化酵素USP10による造血幹細胞および白血病幹細胞維持機構の解明

Papers (8)：

(Bhushan L Thakur), Adrian M Baris, Haiqing Fu, Christophe E Redon, Lorinc S Pongor, Sara Mosavarpour, Jacob M Gross, Sang-Min Jang, Robin Sebastian, Koichi Utani, Lisa M Jenkins, Fred E Indig, and Mirit I Aladjem. Convergence of SIRT1 and ATR signaling to modulate replication origin dormancy. Nucleic Acids Research. 2022. 50. 9. 5111-5128
Masahiko Takahashi, Hiroki Kitaura, Akiyoshi Kakita, Taichi Kakihana, Yoshinori Katsuragi, Masaaki Nameta, Lu Zhang, Yuriko Iwakura, Hiroyuki Nawa, Masaya Higuchi, et al. USP10 Is a Driver of Ubiquitinated Protein Aggregation and Aggresome Formation to Inhibit Apoptosis. iScience. 2018. 9. 433-450
Takashi Kozakai, Masahiko Takahashi, Masaya Higuchi, Toshifumi Hara, Kousuke Saito, Yuetsu Tanaka, Masayoshi Masuko, Jun Takizawa, Hirohito Sone, Masahiro Fujii. MAGI-1 expression is decreased in several types of human T-cell leukemia cell lines, including adult T-cell leukemia. International Journal of Hematology. 2018. 107. 3. 337-344
Regulation of intracellular stress responses by the pleiotropic deubiquitinase USP10. 2017. 42. 2. 41-47
Kaoru Yamawaki, Tatsuya Ishiguro, Yutaro Mori, Kosuke Yoshihara, Kazuaki Suda, Ryo Tamura, Masayuki Yamaguchi, Masayuki Sekine, Katsunori Kashima, Masaya Higuchi, et al. Sox2-dependent inhibition of p21 is associated with poor prognosis of endometrial cancer. CANCER SCIENCE. 2017. 108. 4. 632-640

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Lectures and oral presentations (29)：

Theilovirus 3C protease cleaves innate immune sensor MDA5 to inhibit double-stranded RNA recognition
(第51回日本免疫学会学術集会 2022)
抗RNAウイルス自然免疫応答における脱ユビキチン化酵素USP10の役割
(金沢医科大学医学会第57回学術集会 2022)
CRISPR/Cas9システムを用いたSaffoldウイルス感染受容体同定の試み
(2022年度北陸腸内細菌研究会 2022)
CRISPR/Cas9システムを用いたSaffoldウイルス感染受容体同定の試み
(第68回日本ウイルス学会学術集会 2021)
ヒトパレコウイルスの受容体遺伝子の同定
(第68回日本ウイルス学会学術集会 2021)

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Education (1)：

1993 - 1997 Tohoku University Graduate School Division of Medical Science

Professional career (1)：

Ph.D in Medicine

Work history (5)：

2010/04 - 2016/04 Niigata University Department of Medicine Associate Professor
2006/04 - 2010/03 Niigata University Department of Medicine Lecturer
2001/06 - 2006/03 Niigata University Department of Medicine Assistant Professor
1998/06 - 2001/05 Harvard University Medical School Postdoctoral fellow
1997/04 - 1998/05 Japan Science and Technology Agency Postdoctoral fellow

Association Membership(s) (3)：

日本細菌学会 , 日本癌学会 , 日本ウイルス学会

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