Research field (6):
Obstetrics and gynecology
, Respiratory medicine
, Plastic and reconstructive surgery
, Pharmaceuticals - chemistry and drug development
, Pharmacology
, Pharmaceuticals - health and biochemistry
Research theme for competitive and other funds (13):
2015 - 2018 Development of anti HIV peptide applying multifunctional polypeptide
2015 - 2018 Potential new chemotherapy for breast cancer therapy with a novel KSP inhibitor
2013 - 2015 Poteitial new chemotherapy strategy for human ovarian carcinoma with a novel KSP inhibitor
2009 - 2011 Adipose tissue-derived stem/stromal cells(ASC) therapy to elastase-elicited pulmonary emphysema in rat model
2008 - 2010 Pluripotency of somatic stem cells as new strategy for therapy of CNS regeneration.
2001 - 2003 Brain-derived neurotrophic factor (BDNF) bound with lecithin derivative in order to prolong plasma-half and permeate through blood brain barrier (BBB)
自己細胞を利用した移植再生治療
レシチン化薬剤に関する研究
薬物キャリアーとしてのLipid Microsphereに関する検討
生分解性ポリマーを用いたマイクロカプセルからの薬剤放出
Lecithinization of drugs
Lipid Microspheres (LM) as drug carrier
Drug Release from microcapsules
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Papers (34):
Yuki Ohta, Tsukasa Kobayashi, Yuko Takeba, Masanori Ootaki, Keisuke Kida, Minoru Watanabe, Taroh Iiri, Mitsuko Takenaga, Naoki Matsumoto. Effect of adipose tissue-derived stem/stromal cells on muscle atrophy. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2021. 94. 0. 3-P2
Yamashita Y, Tanaka KI, Yamakawa N, Asano T, Kanda Y, Takafuji A, Kawahara M, Takenaga M, Fukunishi Y, Mizushima T. Chemical modification-mediated optimisation of bronchodilatory activity of mepenzolate, a muscarinic receptor antagonist with anti-inflammatory activity. Bioorganic & medicinal chemistry. 2019. 27. 15. 3339-3346
Asano T, Hattori T, Tanaka KI, Yamakawa N, Suemasu S, Aida S, Kataoka M, Mizushima T, Takenaga M. Antinociception by fluoro-loxoprofen, a novel non-steroidal anti-inflammatory drug with less ulcerogenic effects, in rat models of inflammatory pain. European journal of pharmacology. 2018
Ohta Y, Takenaga M, Hamaguchi A, Ootaki M, Takeba Y, Kobayashi T, Watanabe M, Iiri T, Matsumoto N. Isolation of Adipose-Derived Stem/Stromal Cells from Cryopreserved Fat Tissue and Transplantation into Rats with Spinal Cord Injury. International journal of molecular sciences. 2018. 19. 7
Teita Asano, Mitsuko Takenaga. Adenosine A2B receptors: An optional target for the management of irritable bowel syndrome with diarrhea?. Journal of Clinical Medicine. 2017. 6. 11