Rchr
J-GLOBAL ID:200901040917288410   Update date: Aug. 27, 2020

Kimura Shigenobu

キムラ シゲノブ | Kimura Shigenobu
Affiliation and department:
Job title: Professor
Other affiliations (2):
Research field  (3): Environmental load reduction/restoration technology ,  Structural biochemistry ,  Functional biochemistry
Research keywords  (1): protein, protein engineering, electron transfer, flavoenzyme, expression system, bioremediation
Research theme for competitive and other funds  (6):
  • 2013 - 2016 シアノバクテリアを利用した膜タンパク質大量生産系の構築
  • 2015 - シアノバクテリアの細胞内電子供給系路の解明と新規芳香族化合物分解株の創成
  • 2009 - 2013 貧栄養環境下で芳香族環境汚染物質を分解する新規光合成微生物の改良と展開
  • 2006 - 2009 貧栄養環境下でのPCB汚染除去のための新規光合成微生物の創出
  • 1999 - 2001 ブタ肝臓ミクロソーム電子伝達系生物マシーナリーの立体構造と機能に関する研究
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Papers (59):
  • Takaaki Suzuki, Akito Nishizawa, Masashi Kikuchi, Chihiro Nonaka, Mariko Komuro, Miki Nakayama, Yasuhiro Kashino, Masao Fukuda, Shigenobu Kimura. Biphenyl degradation by recombinant photosynthetic cyanobacterium Synechocystis sp. PCC6803 in an oligotrophic environment using unphysiological electron transfer. Biochem. J. 2019. 476. 3615-3630
  • Yu Hirano, Shigenobu Kimura, Taro Tamada. High-resolution crystal structures of the solubilized domain of porcine cytochrome b5. Acta Crystallographica Section D Biol. Crystallogr. 2015. 71. 1572-1581
  • Gen Okano, Shukuro Igarashi, Yuhei Yamamoto, Shotaro Saito, Yoshitaka Takagai, Takao Ohtomo, Shigenobu Kimura, Osamu Ohno, Yoshio Oka. HPLC-spectrophotometric detection of trace heavy metals via 'cascade' separation and concentration. INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY. 2015. 95. 2. 135-144
  • Akito Nishizawa, Ayaka Harada, Miki Senda, Yuka Tachihara, Daisuke Muramatsu, Shinya Kishigami, Shigemasa Mori, Keisuke Sugiyama, Toshiya Senda, Shigenobu Kimura. Complete pyridine-nucleotide-specific conversion Of an NADH-dependent ferredoxin reductase. BIOCHEMICAL JOURNAL. 2014. 462. 2. 257-265
  • Mitsugu Yamada, Taro Tamada, Kazuki Takeda, Fumiko Matsumoto, Hiraku Ohno, Masayuki Kosugi, Kiyofumi Takaba, Yoshinari Shoyama, Shigenobu Kimura, Ryota Kuroki, et al. Elucidations of the Catalytic Cycle of NADH-Cytochrome b(5) Reductase by X-ray Crystallography: New Insights into Regulation of Efficient Electron Transfer. JOURNAL OF MOLECULAR BIOLOGY. 2013. 425. 22. 4295-4306
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MISC (4):
  • Toshiya Senda, Miki Senda, Shigenobu Kimura, Tetsuo Ishida. Redox control of protein conformation in flavoproteins. Antioxidants & Redox Signaling. 2009. 11. 7. 1741-1766
  • Miki Senda, Shigenobu Kimura, Masao Fukuda, Tetsuo Ishida, Toshiya Senda. Molecular mechanism of the redox-depsndent interaction between NADH-dependent ferredoxin reductase and Rieske-type [2Fe-2S]ferredoxin. Flavins and Flavoproteins 2008 (Fargo, S., Gomez-Moreno, C., Medina, M.) Prensas Universitarias de Zaragoza, Spain. 2008. 113-118
  • Akito Nishizawa, Daisuke Muramatsu, Shigenobu Kimura, Shinya Kishigami, Miki Senda, Toshiya Senda, Masao Fukuda. Inversion of NADH/NADPH-specificity of BphA4 from Pseudomonas sp. strain KKS102 by substitutions of Glu175 and Gln177. Flavins and Flavoproteins 2008 (Fargo, S., Gomez-Moreno, C., Medina, M.) Prensas Universitarias de Zaragoza, Spain. 2008. 273-278
  • Shigenobu Kimura, Akito Nishizawa, Takuya Umemura, Yoshiyuki Fukuda, Chiaki Sano, Eri Ueno. Modulation of the explession level of NADH-cytochrome P450 reductase catalytic domain. Flavins and Flavoproteins 2008 (Fargo, S., Gomez-Moreno, C., Medina, M.) Prensas Universitarias de Zaragoza, Spain. 2008. 583-588
Patents (2):
  • 芳香族化合物分解能を有する光合成生物および芳香族化合物の分解方法
  • 芳香族化合物分解能を有する光合成生物および芳香族化合物の分解方法
Books (3):
  • 貧栄養下で芳香族化合物を分解できる新規光合成微生物
    ケミカルエンジニヤリング 2009
  • Molecular Mechanism of the Redox-dependent Interaction betweenNADH-dependent Ferredoxin Reductase and Rieske-type Ferredoxin
    J. Cryst. Soc. Jpn. 2008
  • Molecular Mechanism of the Redox-dependent Interaction between NADH-dependent Ferredoxin Reductase and Rieske-type [2Fe-2S] Ferredoxin
    化学と生物 2008
Lectures and oral presentations  (179):
  • NADH-シトクロム<i>b</i><sub>5</sub>還元酵素反応系の結晶構造解析
    (日本結晶学会年会 2019)
  • High-resolution structure analysis of the redox system of NADH-cytochrome <I>b</I><SUB>5</SUB> reductase
    (第19回日本蛋白質科学会年会,第71回日本細胞生物学会大会 合同年次大会 2019)
  • Glutathione-dependent Rieske-type ferredoxin-reducing activity of <I>Synechocystis</I> sp. PCC6803 <I>slr0600</I> gene product
    (第19回日本蛋白質科学会年会,第71回日本細胞生物学会大会 合同年次大会 2019)
  • Neutron crystal structure studies of the oxidized form of NADHcytochrome <I>b</I><SUB>5</SUB> reductase
    (A combined conference of the Asian Crystallographic Association (AsCA) and the Society of Crystallographers (AsCA 2018/CRYSTAL 32) 2018)
  • <I>Synechocystis</I> sp. PCC6803由来ジフラビン結合ジスルフィド酸化還元酵素のグルタチオン依存的BphA3還元活性
    (第29回日本化学会関東支部茨城地区研究交流会 2018)
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Education (2):
  • 1982 - 1984 Tohoku University 化学第二専攻 博士課程前期2年の過程
  • - 1984 Graduate School of Tohoku University Chemistry
Professional career (2):
  • Ph.D. (Tohoku University)
  • 博士(理学)東北大学 (東北大学)
Work history (7):
  • 2005/04 - Professor, Department of Biomolecular Functional Engineering, Faculty of Engineering, Ibaraki University
  • 2004/04 - 2005/03 Associate Professor, Graduate School of Life Science, University of Hyogo
  • 2002/04 - 2004/03 Associate Professor, Department of Life Science, Graduate School of Science, Himeji Institute of Technology
  • 1996/10 - 2002/03 Associate Professor, Department of Life Science, Faculty of Science, Himeji Institute of Technology
  • 1992/04 - 1996/09 Reseach Scientist, Basic Research Laboratories, Toray Industries Inc.
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Committee career (2):
  • 2014/10/01 - 日本生化学会 評議員
  • 2012/10/01 - 2013/09/30 日本生化学会 代議員
Awards (2):
  • 2011/09/30 - Japan Society for the Promotion of Science 平成23年度科研費審査委員表彰 科研費の第1段審査(書面審査)の検証結果に基づき、模範となる審査意見を付した審査委員。
  • 2004 - 日本生化学会 JB論文賞 2004年(第12回)
Association Membership(s) (4):
American Society of Biochemistry and Molecular Biology (ASBMB) ,  The Molecular Biology Society of Japan ,  Pritein Science Society of Japan ,  The Japanese Biochemical Society
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