Ishii Naohito

イシイナオヒト | Ishii Naohito

Affiliation and department：
Job title： Professor
Other affiliations (1)：

Kitasato University Graduate School of Medical Sciences

Research field (5)： Other , Pathobiochemistry , Nephrology , Metabolism and endocrinology , Respiratory medicine

Research keywords (12)：臨床化学 , Clinical Chemistry , 病態検査学 , 腎臓生理学 , 近位尿細管 , 糖尿病 , 糖尿病性腎症 , 酸化ストレス , ニトロチロシン , ミトコンドリア , マイトファジー , 呼吸生理学

Research theme for competitive and other funds (15)：

2023 - 2026 Development of novel biomarkers for AKI-to-CKD transition by focusing on hypoxia-induced tubular regeneration.
2023 - 2026 The mechanisms for renal protection by klotho protein supplementation
2021 - 2023 ミトコンドリアとリソソームの品質管理に着目した糖尿病性腎症の早期診断法の開発
2020 - 2022 クロト蛋白補充による腎保護についての研究
2018 - 2021 尿中ミトコンドリアタンパク質に着目した糖尿病性腎症の早期診断法の開発

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Papers (40)：

佐藤直和, 黒崎祥史, 井本明美, 成田実央, 土筆智晶, 鈴木英明, 横場正典, 市川尊文, 片桐真人, 石井直仁. 腎症発症前糖尿病ラットにおける脂肪酸代謝が関わるミトコンドリア品質管理メカニズム. 日本臨床検査医学会誌. 2023. 71. 補冊. 178-178
Tsuneo Takenaka, Arif Hasan, Takeshi Marumo, Tsutomu Inoue, Takashi Miyazaki, Hiromichi Suzuki, Yoshifumi Kurosaki, Naohito Ishii, Akira Nishiyama, Matsuhiko Hayashi. Klotho supplementation reverses renal dysfunction and interstitial fibrosis in remnant kidney. Kidney & blood pressure research. 2023
Yoshifumi Kurosaki, Akemi Imoto, Fumitaka Kawakami, Motoshi Ouchi, Asuka Morita, Masanori Yokoba, Tsuneo Takenaka, Takafumi Ichikawa, Masato Katagiri, Rikke Nielsen, et al. In vitro study on effect of bardoxolone methyl on cisplatin-induced cellular senescence in human proximal tubular cells. Molecular and cellular biochemistry. 2022. 477. 3. 689-699
Tomoaki Tsukushi, Ryota Shinohara, Yuzuru Adachi, Yoshifumi Kurosaki, Naohito Ishii, Masato Katagiri, Shinichi Munekata, Yuhsaku Kanoh. Air contamination of therapeutic drug monitoring assay reagents results in falsely high plasma ammonia levels. Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 2022. 000456322210745-000456322210745
Tsuneo Takenaka, Arif Hasan, Takeshi Marumo, Hiroyuki Kobori, Tsutomu Inoue, Takashi Miyazaki, Hiromichi Suzuki, Akira Nishiyama, Naohito Ishii, Matsuhiko Hayashi. Klotho supplementation attenuates blood pressure and albuminuria in murine model of IgA nephropathy. Journal of hypertension. 2021. 39. 8. 1567-1576

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MISC (3)：

黒崎祥史, 黒崎祥史, 五十嵐大士, 井本明美, 井本明美, 阿部篤, 土筆智晶, 小幡進, 横場正典, 横場正典, et al. 近位尿細管上皮細胞において高血糖による酸化ストレスの亢進はmegalin発現を上昇させる. 臨床病理. 2016. 64. 補冊. 16-8
Hidero Kitasato, Shinichiro Takahashi, Makoto Ohbu, Fumiya Obata, Zensuke Ogawa, Yuichi Sato, Manabu Hattori, Tatsuo Saito-Taki, Kazuya Hara, Tetsuroh Okano, et al. [Educational program in the Medical Science Course, Kitasato University School of Allied Health Sciences]. Rinsho byori. The Japanese journal of clinical pathology. 2008. 56. 7. 606-11
Ishii N, Okazaki T, Katagiri M, Nagai T. Effect of high glucose on superoxide anion production and superoxide dismutase activity in the renal cortex of rats. J. Anal Bio-Sci. 2006. 29:151-156

Books (2)：

Altered renal microvascularture function in early diabetes.
In: Contemporary Diabetes - The Diabetic Kidney, edited by Cortes P and Mogensen CE. Totowa, NJ: Humana Press. 2006
Effect of in vivo glucose loading on urinary enzyme excretion in rats
In: Progress in Clinical Biochemistry, edited by Miyai K, Kanno T, Ishikawa E,Elsevier Science Publishers B.V. 1992

Lectures and oral presentations (54)：

Mitochondrial quality control mechanisms and fatty acid metabolism in renal cortex during the normoalbuminuric stage of diabetes mellitus.
(Kidney Week 2022, American Society of Nephrology, Orlando, USA 2022)
Protection of renal function by inducing mitophagy in the proximal tubule during the normoalbuminuric stage of diabetes mellitus.
(The 17th Congress of Asian Society of. Clinical Pathology and Laboratory Medicine, Kobe, Japan 2022)
Comparison of HSP72 and anti-HSP70 antibodies with thrombosis markers in patients with thrombosis.
(he 17th Congress of Asian Society of. Clinical Pathology and Laboratory Medicine, Kobe, Japan 2022)
Fatty acid-associated albumin induces proliferation and senescence of proximal tubular cells.
(59th European Renal Association Congress, Paris, France 2022)
Mitophagy-related renal and proximal tubular protection during the normoalbuminuric stage of diabetes mellitus.
(Kidney Week 2021 (Hybrid Format), American Society of Nephrology, San Diego, USA 2021)

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Education (2)：

Kitasato University
Kitasato University

Professional career (2)：

Master of Arts (Kitasato University)
Doctor of Pharmaceutical Science (Tokyo University of Pharmacy and Life Science)

Work history (6)：

2013/04 - 現在北里大学大学院医療系研究科・教授
2013/04 - 現在北里大学医療衛生学部・教授
2005/04 - 2013/03 北里大学大学院医療系研究科・講師
2005/04 - 2013/03 北里大学医療衛生学部・講師
1998/08 - 2005/03 北里大学医療衛生学部・助手

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Committee career (17)：

2023 - 現在日本臨床検査学教育協議会国際協力委員会担当理事
2023 - 現在日本臨床検査学教育協議会理事
2023 - 現在日本臨床化学会常務理事
2023 - 現在日本臨床化学会理事
2022 - 現在日本臨床化学会若手育成委員会

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Awards (5)：

2008 - 2008 National Academy of Clinical Biochemistry (NACB) Distinguished Abstract Awards, American Association for Clinical Chemistry, AACC)
2003 - 北里大学学術奨励研究
2002 - 日本臨床化学会学術賞
2002 - 北里大学学術奨励研究
2001 - 日本臨床化学会奨励賞

Association Membership(s) (9)：

日本ワンヘルスサイエンス学会 , 日本プロテオーム学会 , 日本臨床検査学教育協議会・日本臨床検査学教育学会 , The American Association for Clinical Chemistry(AACC, アメリカ臨床化学会) , 日本ミトコンドリア学会 , 日本生化学会 , 日本臨床検査医学会 , 日本腎臓学会 , 日本臨床化学会

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