Ozeki Takeshi

オオゼキタケシ | Ozeki Takeshi

Affiliation and department：
Job title： Reseacrch Scientist

Research field (3)： Clinical pharmacy , Pharmacology , Pharmaceuticals - health and biochemistry

Research keywords (16)：薬剤反応性 , 発現制御 , 遺伝子 , 免疫学 , 転写因子 , 薬物動熊学 , オーターメード医療 , ゲノム , 遺伝学 , 薬物動態学 , 遺伝的多型 , 個体差 , 薬効 , Genetic Polymorphism , Interindividual Variation , Drug Efficacy

Research theme for competitive and other funds (6)：

2009 - 2010 Associations of hepatocyte nuclear factors HNF3 and HNF6 to quantitative variation of drug metabolizing enzymes
2007 - 2008 Establishment of personalized administration method of infliximab for Crohn's disease
2005 - 2006 ステロイド受容体認識配列における遺伝的多様性の分子基盤の構築
2005 - 2006 ステロイド受容体認識配列における遺伝的多様性の分子基盤の構築
医薬品の薬効発現の個体差に関わる遺伝的因子の探索

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Papers (65)：

Keiko Hikino, Yuichi Abe, Kazumi Sakashita, Takeshi Ozeki, Taisei Mushiroda. Characteristics of adverse drug reactions associated with antiepileptics at a tertiary children's hospital in Japan: A retrospective observational cohort study. Epilepsy research. 2021. 173. 106614-106614
Ryosuke Nakamura, Takeshi Ozeki, Noriaki Hirayama, Akihiro Sekine, Taiki Yamashita, Yoichi Mashimo, Yoshiko Mizukawa, Tetsuo Shiohara, Hideaki Watanabe, Hirohiko Sueki, et al. Association of HLA-A*11:01 with Sulfonamide-Related Severe Cutaneous Adverse Reactions in Japanese Patients. The Journal of investigative dermatology. 2020. 140. 8. 1659-1662
Keiko Hikino, Takeshi Ozeki, Masaru Koido, Chikashi Terao, Yoichiro Kamatani, Yoshiko Mizukawa, Tetsuo Shiohara, Mikiko Tohyama, Hiroaki Azukizawa, Michiko Aihara, et al. HLA-B*51:01 and CYP2C9*3 Are Risk Factors for Phenytoin-Induced Eruption in the Japanese Population: Analysis of Data From the Biobank Japan Project. Clinical pharmacology and therapeutics. 2020. 107. 5. 1170-1178
Keiko Hikino, Takeshi Ozeki, Masaru Koido, Chikashi Terao, Yoichiro Kamatani, Yoshinori Murakami, Michiaki Kubo, Taisei Mushiroda. Comparison of effects of UGT1A1*6 and UGT1A1*28 on irinotecan-induced adverse reactions in the Japanese population: analysis of the Biobank Japan Project. Journal of human genetics. 2019. 64. 12. 1195-1202
Kishikawa T, Momozawa Y, Ozeki T, Mushiroda T, Inohara H, Kamatani Y, Kubo M, Okada Y. Empirical evaluation of variant calling accuracy using ultra-deep whole-genome sequencing data. Scientific reports. 2019. 9. 1. 1784-1784

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MISC (94)：

Kohei Otsubo, Kaname Nosaki, Chiyo K. Imamura, Hiroaki Ogata, Akitaka Fujita, Shinya Sakata, Fumihiko Hirai, Gouji Toyokawa, Eiji Iwama, Taishi Harada, et al. Phase I Study of Salazosulfapyridine Targeting Cancer Stem Cells in Combination with CDDP and Pemetrexed for Chenno-Naive Advanced Non-Sq NSCLC. JOURNAL OF THORACIC ONCOLOGY. 2017. 12. 1. S1271-S1272
齋藤竹生, 池田匡志, 莚田泰誠, 大関健志, 近藤健治, 島崎愛夕, 川瀬康平, 山森英長, 安田由華, 藤本美智子, et al. 向精神薬の薬理ゲノム学的研究:クロザピンの薬理ゲノム学的研究. 日本生物学的精神医学会(Web). 2016. 38th
齋藤竹生, 池田匡志, 莚田泰誠, 大関健志, 近藤健治, 島崎愛夕, 川瀬康平, 橋本修二, 山森英長, 安田由華, et al. クロザピン誘発性無顆粒球症・顆粒球減少症に関する薬理ゲノム学的研究. 日本臨床精神神経薬理学会プログラム・抄録集. 2016. 26th
上田真由美, 上田真由美, 上田真由美, 澤井裕美, 外園千恵, 人見祐基, 鹿庭なほ子, 鹿庭なほ子, 大関健志, 莚田泰誠, et al. 重篤な粘膜障害を伴う感冒薬関連Stevens-Johnson症候群の新規疾患関連遺伝子IKZF1. 日本遺伝子診療学会大会プログラム・抄録集. 2014. 21st
大関健志, 久保充明. Personalized therapy for epilepsy : Genetic markers associated with epilepsy susceptibility and adverse drug reactions. Epilepsy : てんかんの総合学術誌. 2013. 7. 1. 29-36

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Patents (2)：

Lectures and oral presentations (54)：

In silico Analysis of Interactions between HLA-A*31:01 and carbamazepine-related Compounds
(Chem-Bio Informatics Journal 2016)
向精神薬の薬理ゲノム学的研究:クロザピンの薬理ゲノム学的研究
(日本生物学的精神医学会(Web) 2016)
クロザピン誘発性無顆粒球症・顆粒球減少症に関する薬理ゲノム学的研究
(日本臨床精神神経薬理学会プログラム・抄録集 2016)
日本人におけるβ-ラクタム系抗菌薬誘発薬疹の遺伝的リスク因子の探索
(日本人類遺伝学会大会プログラム・抄録集 2015)
重篤な粘膜障害を伴う感冒薬関連Stevens-Johnson症候群の新規疾患関連遺伝子IKZF1
(日本遺伝子診療学会大会プログラム・抄録集 2014)

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Education (4)：

- 2001 Hokkaido University
- 2001 Hokkaido University Graduate School, Division of Pharmaceutical Sciences
- 1996 Hokkaido University Faculty of Pharmaceutical Sciences
- 1996 Hokkaido University Faculty of Pharmaceutical Science

Professional career (1)：

博士(薬学) (北海道大学)

Work history (10)：

2010 - RIKEN
2003 - 2009 Tokyo University of Pharmacy and Life Sciences School of Pharmacy
2003 - 2009 : Lecturer, School of Pharmacy,
2009 - - 理化学研究所横浜研究所ゲノム医科学研究センター研究員
2009 - - : Research Scientist, Center for Genomic Medicine,

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Association Membership(s) (6)：

ISSX (International Society for the Study of Xenobiotics) , 日本TDM学会 , 日本薬物動態学会 , 日本医療薬学会 , 日本薬学会 , International Society for the Study of Xenobiotics

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