Miyoshi Daisuke

ミヨシダイスケ | Miyoshi Daisuke

Affiliation and department：
Job title： Professor

Research field (5)： Biochemistry , Electronic devices and equipment , Nano/micro-systems , Nanobioscience , Nanomaterials

Research keywords (35)：生命科学 , 核酸化学 , 生命機能工学 , ナノ粒子 , 分子クラウディング , 金属イオン , バイオセンサー , ヒストン , ナノテクノロジー , ナノバイオ , DDS , 生体モデル化学 , nanoparticle , nanotechnology , nanobiotechnology , functional material , molecular crowding , kinetics , thermodynamics , G-quadruplex , peptide , RNA , peptide , DNA , Phase separation , -DNA , テロメア , 細胞環境化学 , 生命分子化学 , DNA , telomere , Nanotechnology , Biotechnology , Life Science , biomolecular chemistry

Research theme for competitive and other funds (30)：

2021 - 2024 Model system for nucleic acid-protein liquid-liquid phase separation
2020 - 2022 Formation and function of nucleolus depending on rRNA G-quadruplexes
2019 - 2022 核酸四重らせん構造リガンドを用いた細胞内相分離現象の制御
2019 - 2021 核酸四重らせん構造リガンドを用いた細胞内相分離現象の制御
2018 - RNA四重らせん構造によるストレス顆粒の制御

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Papers (97)：

Kohei Yokosawa, Mitsuki Tsuruta, Shinji Kajimoto, Naoki Sugimoto, Daisuke Miyoshi, Takakazu Nakabayashi. Quantification of the concentration in a droplet formed by liquid-liquid phase separation of G-quadruplex-forming RNA. Chemical Physics Letters. 2023. 826. 140634-140634
Yoshiki Hashimoto, Yoshiki Imagawa, Kaho Nagano, Ryuichi Maeda, Naho Nagahama, Takeru Torii, Natsuki Kinoshita, Nagisa Takamiya, Keiko Kawauchi, Hisae Tatesishi-Karimata, et al. Simple and fast screening for structure-selective G-quadruplex ligands. Chemical communications (Cambridge, England). 2023. 59. 33. 4891-4894
Mitsuki Tsuruta, Takeru Torii, Kazuki Kohata, Keiko Kawauchi, Hisae Tateishi-Karimata, Naoki Sugimoto, Daisuke Miyoshi. Controlling liquid-liquid phase separation of G-quadruplex-forming RNAs in a sequence-specific manner. Chemical communications (Cambridge, England). 2022. 58. 93. 12931-12934
Wataru Sugimoto, Natsuki Kinoshita, Minori Nakata, Tatsuya Ohyama, Hisae Tateishi-Karimata, Takahito Nishikata, Naoki Sugimoto, Daisuke Miyoshi, Keiko Kawauchi. Intramolecular G-quadruplex-hairpin loop structure competition of a GC-rich exon region in the TMPRSS2 gene. Chemical Communications. 2022. 58. 1. 48-51
杉本渉, 橋本佳樹, 川内敬子, 三好大輔. Molecularly targeted photodynamic therapy for cancer mRNAs. Bio Clinica. 2021. 36. 5. 65-67

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MISC (83)：

鶴田充生, 取井猛流, 小畠一起, 川内敬子, 建石(狩俣)寿枝, 杉本直己, 三好大輔. Droplet degradation targeted at secondary structure of nucleic acid. 日本化学会春季年会講演予稿集(Web). 2022. 102nd
橋本佳樹, 取井猛流, 藤田ひな, 川内敬子, 建石寿枝, 杉本直己, 三好大輔. A Novel G4 Ligand Screening System with G4-selective Fluorescent Probe. 日本化学会春季年会講演予稿集(Web). 2022. 102nd
月生雅也, 取井猛流, 建石寿枝, 西方敬人, 杉本直己, 三好大輔, 川内敬子. Analysis of liquid-liquid phase separation phenomenon by interaction between rDNA-derived DNA G4 and RGG peptide. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
取井猛流, 杉本渉, 建石寿枝, 鶴田充生, 月生雅也, 村嶋貴之, 西方敬人, 杉本直己, 三好大輔, 川内敬子. Molecular mechanism of the G-quadruplex formation for ribosomal DNA. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
小畠一起, 杉本渉, 川内敬子, 杉本直己, 杉本直己, 三好大輔. Liquid-liquid phase separation of short G-quadruplex RNA oligonucleotides and RGG oligo peptides. 日本化学会春季年会講演予稿集(CD-ROM). 2020. 100th

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Patents (11)：

核酸鎖の四重螺旋構造の検出方法
テロメラーゼ活性の検出方法
Method for inhibiting telomerase reaction using an anionic phthalocyanine compound
Method for detecting G-quadruplex, method for detecting G-quadruplex-forming DNA and method for determining telomerase activity
核酸を用いた紫外線吸収剤

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Books (18)：

核酸化学ハンドブック
日本核酸化学会 2020
相分離生物学の全貌
東京化学同人 2020 ISBN:9784807913466
Cell and Molecular Mechanics in Health and Disease
Hindawi Limited 2017
Chapter 6. Assays for Telomerase Activity toward Applications of Cancer Diagnosis in G-Quadruplex Structures, Formation and Role in Biology
Nova Science Publishers 2016
DNA G-quadruplexes for organic nanomatrials
2015

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Lectures and oral presentations (138)：

What is the canonical structure of nucleic acids in cells?
(Institute Seminar, National Institute of Technology, Nagaland 2018)
DNA and RNA G-quadruplexes under molecular crowding conditions
(IGIB seminar 2018)
DNA and RNA G-quadruplexes: structure, function, and ligand under cell-mimicking molecular crowding conditions
(International Conference on Current Trends in Materials Science and Engineering (CTMSE 2018) 2018)
RNA foldingにおける三次元的相互作用の共存溶質による安定化効果
(ConBio2017(第40回日本分子生物学会年会) 2017)
Development of cell nucleus mimicking system based on molecular crowding effects on DNA structures
(2nd International Symposium on Biofunctional Chemistry (ISBC2017) 2017)

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Works (121)：

ケミカルバイオロジー2.0
2019 -
G-Quadruplex: a Versatile DNA structure in vivo and in vitro
2007 -
Conformational switch of a functional nanowire based on the DNA G-quadruplex
2007 -
Effects of cosolutes on the thermodynamic stability of parallel DNA duplex and triplex
2007 -
Functional DNA materials controlled by surrounding conditions
2007 -

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Education (2)：

- 2003 Konan University Graduate School, Division of Science and Technology
- 1996 Konan University Faculty of Science

Professional career (1)：

博士(理学) (甲南大学)

Work history (5)：

2015/04/01 - 現在 KONAN UNIVERSITY Faculty of Frontiers of Innovative Research in Science and Technology Faculty of Frontiers of Innovative Research in Science and Technology Department of Nanobiochemistry Professor
2009/04/01 - 2015/03/31 KONAN UNIVERSITY Faculty of Frontiers of Innovative Research in Science and Technology Faculty of Frontiers of Innovative Research in Science and Technology Department of Nanobiochemistry Associate Professor
2004/04/01 - 2009/03/31 KONAN UNIVERSITY Lecturer
2003/04/01 - 2004/03/31 米国イリノイ大学アーバナ・シャンペーン校博士研究員
Konan University Frontier Institute for Biomolecular Engineering Research Assistant Professor

Committee career (9)：

2019/04 - 現在日本化学会 CSJ化学フェスタ実行委員
2017/04 - 現在日本核酸化学学会評議員
2016/05 - 現在日本ナノメディシン交流協会理事
2019/12 - 日本ナノメディシン交流協会 13th Anniversary International Symposium on Nanomedicine (ISNM2019)実行委員長
2019/10 - 日本生物物理学会第57回日本生物物理学会年会シンポジウムオーガナイザー

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Awards (6)：

2015/03 - 村尾育英会村尾育英会学術賞
2013/10 - バイオインダストリー協会化学・生物素材研究開発奨励賞
2011/11/01 - The organizing committee and executive committee of the 38th International Symposium on Nucleic Acid Chemistry (ISNAC2011) ISNAC Outstanding Oral Presentation Award for Young Scientist in 2011
2011/03/01 - 日本化学会日本化学会第91春季年会若い世代の特別講演賞
2007/09/01 - 日本化学会日本化学会生体機能関連化学シンポジウム講演賞

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Association Membership(s) (6)：

日本化学会 , Chemical Society of Japan , 生命化学研究会 , 生体機能化学部会 , バイオテクノロジー部会 , 米国化学会

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