Rchr
J-GLOBAL ID：200901041482627257
Update date: Apr. 19, 2024
Kinoshita Taroh
キノシタ タロウ | Kinoshita Taroh
Affiliation and department：
Job title：
Specially-appointed Professor
Homepage URL (1)：
http://www.biken.osaka-u.ac.jp/
Research field (3)：
Functional biochemistry
, Immunology
, Structural biochemistry
Research theme for competitive and other funds (39)：
- 2021 - 2024 グリコシルホスファチジルイノシトール (GPI) 生合成の制御メカニズムの解明
- 2017 - 2022 上皮細胞の極性輸送における細胞小器官内選別輸送ゾーンの有無とその意義
- 2016 - 2021 Physiological and pathological roles of GPI side chains and free GPI
- 2015 - 2017 Analysos of metabolic abnormality which causes clonal expansion in Paroxysmal nocturnal hemoglobinuria
- 2009 - 2014 Molecular mechanisms and functions of structural changes of protein GPI-anchors
- 2011 - 2013 Analysis for the molecular mechanism of Inheited GPI Deficiency
- 2007 - 2008 Stage specific modifications of GPI anchor in Trypanosoma brucei
- 2006 - 2007 Investigation of the mechanism for clonal expansion of GPI negative cells in paroxysmal nocturnal hemoglobinuria
- 2002 - 2007 Function regulation of proteins and molecular complexes with glycosylation.
- 2005 - 2006 Biosynthesis and functions of GPI-anchored proteins in African trypanosomes
- 2002 - 2006 GPIアンカー合成の調節機構と合成不全症
- 2004 - 2005 Investigation into the mechanism for expansion of abnormal clone in paroxysmal nocturnal hemoglobinuria
- 2004 - 2005 The regulation of functions and expressions of proteins by glycosylphosphatidylinositol-anchor
- 2004 - 2005 GPIアンカー型蛋白質の輸送機構の解明:ラフトヘのアプローチとして
- 1997 - 2003 感染症と免疫病の分子生物学と医学
- 2001 - 2002 Biosynthesis pathway of GPI anchored proteins.
- 1999 - 2000 Mechanism of biosynthesis of protein GPI anchors.
- 1998 - 2000 糖鎖遺伝子による細胞リモデリング
- 1998 - 1999 Molecular basis for immunological disease
- 1997 - 1998 Molecular mechanism of GPI anchir biosynthesis
- 1997 - 1997 発作性夜間血色素尿症の分子病態学
- 1996 - 1996 Characterization of GPI anchor biosynthesis genes.
- 1996 - 1996 発作性夜間血色素尿症の分子病態
- 1996 - 1996 アラリアGPI アンカーの生合成遺伝子群のクローニング
- 1993 - 1995 Cloning of a GPI-anchor synthsis gene, PIG-A and characterization of its clinical significanece
- 1993 - 1995 Regulation of Gene Expression
- 1992 - 1994 Studies on the genes controlling lethality and development of the silkmoth, Bombyx mori.
- 1992 - 1993 Molecular mechanisms of bacterial toxins on host cells
- 1992 - 1992 微生物由来物質による生体細胞情報のモジュレイション
- 1992 - 1992 補体の起炎反応を活用した抗腫瘍免疫誘導法の研究
- 1991 - 1992 Roles of complement and complement receptor in self defense
- 1991 - 1992 Structure and function of chemotactic factor, C5a, and its receptor
- 1989 - 1991 Analysis of Resistance Mechanism of Complement-resistant Bacteria
- 1989 - 1990 Structural and Functional Analysis of Complement C3/C5 Convertases.
- 1988 - 1989 Analysis of immune bactericidal reaction by human complement component C9-deficient serum
- GPIアンカーの生合式経路研究
- 発作性夜間血色素尿症の病因研究
- Biosynthesis of the GPI anchor
- Pathogenesis of paroxysmal nocturnal hemoglobin uria.
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Papers (289)：
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Yoshiko Murakami, Saori Umeshita, Kae Imanishi, Yoshichika Yoshioka, Akinori Ninomiya, Takehiko Sunabori, Shibi Likhite, Masato Koike, Kathrin C. Meyer, Taroh Kinoshita. AAV-based gene therapy ameliorated CNS-specific GPI defect in mouse models. Molecular Therapy - Methods & Clinical Development. 2024. 32. 1. 101176-101176
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Yicheng Wang, Taroh Kinoshita. The role of lipid scramblases in regulating lipid distributions at cellular membranes. Biochemical Society transactions. 2023
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Shu-Ya Cao, Yi-Shi Liu, Xiao-Dong Gao, Taroh Kinoshita, Morihisa Fujita. A lipid scramblase TMEM41B is involved in the processing and transport of GPI-anchored proteins. Journal of biochemistry. 2023. 174. 2. 109-123
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Yi-Shi Liu, Yicheng Wang, Xiaoman Zhou, Linpei Zhang, Ganglong Yang, Xiao-Dong Gao, Yoshiko Murakami, Morihisa Fujita, Taroh Kinoshita. Accumulated precursors of specific GPI-anchored proteins upregulate GPI biosynthesis with ARV1. The Journal of cell biology. 2023. 222. 5
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Atsushi Kobayashi, Tetsuya Hirata, Taishi Shimazaki, Yoshiko Munesue, Keisuke Aoshima, Takashi Kimura, Junko Nio-Kobayashi, Rie Hasebe, Atsuko Takeuchi, Yuichi Matsuura, et al. A point mutation in GPI-attachment signal peptide accelerates the development of prion disease. Acta neuropathologica. 2023. 145. 5. 637-650
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MISC (112)：
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Yoshiko Murakami, Taroh Kinoshita. GPI Anchor and Its Deficiency. Trends in Glycoscience and Glycotechnology. 2024. 36. 209. E1-E5
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Taroh Kinoshita. Biosynthesis and biology of mammalian GPI-anchored proteins. Open Biology. 2020. 10. 3
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Dimitrios C. Mastellos, Anna M. Blom, E. Sander Connolly, Mohamed R. Daha, Brian V. Geisbrecht, Berhane Ghebrehiwet, Piet Gros, George Hajishengallis, V. Michael Holers, Markus Huber-Lang, et al. ‘Stealth’ corporate innovation: an emerging threat for therapeutic drug development. Nature Immunology. 2019. 20. 11. 1409-1413
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西村 洋子, 村上 良子, 木下 タロウ, 谷河 純平, 青天目 信, 前垣 義弘. 上衣下出血後のWest症候群としてフォローしていたGPI欠損症の1例. てんかん研究. 2018. 36. 1. 68-68
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谷河 純平, 岡本 伸彦, 富永 康仁, 北井 征宏, 青天目 信, 宮武 聡子, 三宅 紀子, 松本 直通, 木下 タロウ, 村上 良子, et al. 先天性GPI欠損症と鑑別を要した症例を含むZTTK症候群の新規3例の検討. 脳と発達. 2018. 50. Suppl. S380-S380
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Books (1)：
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Essentials of glycobiology
Cold Spring Harbor Laboratory Press 2022 ISBN:9781621824213
Education (4)：
- 1977 - 1981 Osaka University Graduate School of Medicine Bacteriology
- 1974 - 1977 The University of Tokyo Graduate School of Agricultural Science
- 1972 - 1974 The University of Tokyo
- 1970 - 1972 The University of Tokyo
Professional career (2)：
Work history (10)：
- 2024/04 - 現在 Osaka University Specially-appointed Professor
- 2022/04 - 2024/04 Osaka University
- 2022/04 - 2024/04 Osaka University Research Institute for Microbial Diseases
- 2007 - 現在 Osaka University Immunology Frontier Research Center Principal Investigator
- 2017 - 2022 Osaka University Yabumoto Department of Intractable Disease Research, Research Institute for Microbial Diseases Endowed Chair Professor
- 1990 - 2017 Osaka University Department of Immunoregulation, Research Institute for Microbial Diseases Professor
- 2003 - 2007 Osaka University Research Institute for Microbial Diseases Director
- 1988 - 1990 Osaka University Department of Bacteriology, Medical School Assistant Professor
- 1982 - 1988 Osaka University Department of Bacteriology, Medical School Research Associate
- 1981 - 1982 Osaka University Department of Bacteriology, Medical School Postdoctoral Fellow supported by Japan Society for Promotion of Sciences
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Committee career (3)：
- 1991 - 2024/03 生体防御学会 運営委員
- 2000 - 2004 国際補体学会(International Complement Society) 理事
- 1989 - 日本免疫学会 運営委員
Awards (9)：
- 2023/11 - Society for Glycobiology Karl Meyer Lectureship Award
- 2022 - 太田原豊一賞
- 2021 - 早石修記念賞
- 2018 - 紫綬褒章
- 2017 - 日本免疫学会 ヒト免疫研究賞
- 2017 - Takeda Medical Prize
- 2015 - International Glycoconjugate Organization IGO Award 2015
- 2010 - 文部科学省 文部科学大臣表彰(科学技術賞:研究部門)
- 2001 - 大阪科学賞(第19回)
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Association Membership(s) (6)：
国際補体学会(International Complement Society)
, アメリカ免疫学会(American Association of Immunologists)
, 生体防御学会
, 日本生化学会
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, 日本免疫学会
