Rchr
J-GLOBAL ID:200901041561532113   Update date: Jul. 16, 2024

Nagano Masanobu

ナガノ マサノブ | Nagano Masanobu
Affiliation and department:
Research field  (2): Bioorganic chemistry ,  Pharmaceuticals - chemistry and drug development
Research keywords  (7): Antibody-drug conjugates ,  タンパク質修飾 ,  ペプチド触媒 ,  In vitro selection ,  フォールダマー ,  ワクチン ,  Aptamer
Research theme for competitive and other funds  (3):
  • 2022 - 2025 Precision macromolecular evolution system combined use of nucleic acid and high-precision separation methods
  • 2021 - 2024 Selection of small molecules modulating endogenous antibodies
  • 2013 - 2016 革新的創薬を目指した環状ペプチドライブラリーの構築
Papers (32):
  • Masanobu Nagano, Kazuki Kubota, Asuka Sakata, Rei Nakamura, Toru Yoshitomi, Koji Wakui, Keitaro Yoshimoto. A neutralizable dimeric anti-thrombin aptamer with potent anticoagulant activity in mice. Molecular Therapy - Nucleic Acids. 2023
  • Romualdo Troisi, Valeria Napolitano, Emanuele Rossitto, Waleed Osman, Masanobu Nagano, Koji Wakui, Grzegorz M Popowicz, Keitaro Yoshimoto, Filomena Sica. Steric hindrance and structural flexibility shape the functional properties of a guanine-rich oligonucleotide. Nucleic acids research. 2023
  • Masanobu Nagano, Sosuke Nakano, Keitaro Yoshimoto. Evaluation of G-quartet-forming deoxyguanines in antiparallel G-quadruplexes using optical spectroscopy and deoxyguanine-to-deoxythymidine scanning. Analytical biochemistry. 2022. 658. 114903-114903
  • Masanobu Nagano, Takumi Toda, Kurumi Makino, Hiroko Miki, Yoshiaki Sugizaki, Hideyuki Tomizawa, Atsunobu Isobayashi, Keitaro Yoshimoto. Discovery of a Highly Specific Anti-methotrexate (MTX) DNA Aptamer for Antibody-Independent MTX Detection. Analytical chemistry. 2022
  • Masanobu Nagano, Satoshi Ishida, Hiroaki Suga. Inner residues of macrothiolactone in autoinducer peptides I/IV circumvent spontaneous S-to-O acyl transfer to the upstream serine residue. RSC CHEMICAL BIOLOGY. 2022
more...
MISC (37):
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Books (5):
  • Mid-Sized Macrocyclic Peptides as a New Drug Modality
    Springer Nature, 2021
  • ペプチドから「擬天然大環状ペプチド」へのモダリティーの拡張
    有機合成化学協会誌 2020
  • 抗体-薬物複合体における水溶性リンカーの重要性
    ファルマシア-公益社団法人 日本薬学会 2016
  • 機能性大環状ポリペプチドの翻訳合成とRaPID探索
    高分子-公益社団法人 高分子学会 2014
  • 未来を切り拓く特殊ペプチド創薬
    ファルマシア-公益社団法人 日本薬学会 2014
Education (3):
  • 2007 - 2010 九州大学大学院 薬学府 創薬科学専攻 博士課程
  • 2005 - 2007 Kyushu University Graduate School of Pharmaceutical Sciences
  • 2000 - 2004 Daiichi University, College of Pharmaceutical Sciences Faculty of Pharmaceutical Sciences Course of Pharmaceutical Technology
Work history (5):
  • 2020/09 - 2023/04 The University of Tokyo Department of Art and Sciences
  • 2013/01 - 2020/08 The University of Tokyo Graduate School of Chemistry Postdoc
  • 2013/04 - 2016/03 日本学術振興会 特別研究員(PD)
  • 2010/04 - 2012/12 The Scripps Research Institute Department of Molecular Biology and Chemistry Research Associate
  • 2007/04 - 2010/03 日本学術振興会 特別研究員(DC1)
Association Membership(s) (6):
THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN ,  JAPANESE SOCIETY FOR CHEMICAL BIOLOGY ,  The Japanese Peptide Society ,  日本薬学会 ,  日本化学会 ,  日本化学会生体機能関連化学部会
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