Nagano Masanobu

ナガノマサノブ | Nagano Masanobu

Affiliation and department：

Research field (2)： Bioorganic chemistry , Pharmaceuticals - chemistry and drug development

Research keywords (7)： Antibody-drug conjugates , タンパク質修飾 , ペプチド触媒 , In vitro selection , フォールダマー , ワクチン , Aptamer

Research theme for competitive and other funds (3)：

2022 - 2025 Precision macromolecular evolution system combined use of nucleic acid and high-precision separation methods
2021 - 2024 Selection of small molecules modulating endogenous antibodies
2013 - 2016 革新的創薬を目指した環状ペプチドライブラリーの構築

Papers (32)：

Masanobu Nagano, Kazuki Kubota, Asuka Sakata, Rei Nakamura, Toru Yoshitomi, Koji Wakui, Keitaro Yoshimoto. A neutralizable dimeric anti-thrombin aptamer with potent anticoagulant activity in mice. Molecular Therapy - Nucleic Acids. 2023
Romualdo Troisi, Valeria Napolitano, Emanuele Rossitto, Waleed Osman, Masanobu Nagano, Koji Wakui, Grzegorz M Popowicz, Keitaro Yoshimoto, Filomena Sica. Steric hindrance and structural flexibility shape the functional properties of a guanine-rich oligonucleotide. Nucleic acids research. 2023
Masanobu Nagano, Sosuke Nakano, Keitaro Yoshimoto. Evaluation of G-quartet-forming deoxyguanines in antiparallel G-quadruplexes using optical spectroscopy and deoxyguanine-to-deoxythymidine scanning. Analytical biochemistry. 2022. 658. 114903-114903
Masanobu Nagano, Takumi Toda, Kurumi Makino, Hiroko Miki, Yoshiaki Sugizaki, Hideyuki Tomizawa, Atsunobu Isobayashi, Keitaro Yoshimoto. Discovery of a Highly Specific Anti-methotrexate (MTX) DNA Aptamer for Antibody-Independent MTX Detection. Analytical chemistry. 2022
Masanobu Nagano, Satoshi Ishida, Hiroaki Suga. Inner residues of macrothiolactone in autoinducer peptides I/IV circumvent spontaneous S-to-O acyl transfer to the upstream serine residue. RSC CHEMICAL BIOLOGY. 2022

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MISC (37)：

Hiroaki Suga, Toru Yoshitomi, Masanobu Nagano. Cover story: Highlight reviews: Ribosomal synthesis of functional macrocyclic polypeptides and rapid discovery of bioactive polypeptides. Kobunshi. 2014. 63. 10. 712-714
栗原正明, 佐藤由紀子, 出水庸介, 山縣奈々子, 奥田晴宏, 長野正展, 土井光暢, 田中正一, 末宗洋. α,α-ジ置換アミノ酸を含むオリゴペプチドのコンフォメーション予測と解析. 日本薬学会年会要旨集. 2011. 131st. 2. 184
TANAKA Masakazu, NAGANO Masanobu, DOI Mitsunobu, KURIHARA Masaaki, SUEMUNE Hiroshi. Stabilized α-Helical Peptide-Catalyzed Asymmetric Epoxidation of Chalcone Derivatives. 2011. 2010. 213-213
KURIHARA Masaaki, DEMIZU Yosuke, SATO Yukiko, YAMAGATA Nanako, OKUDA Haruhiro, NAGANO Masanobu, DOI Mitsunobu, TANAKA Masakazu, SUEMUNE Hiroshi. Computational Study on Conformation of Oligopeptides Containing .ALPHA.,.ALPHA.-Disubstituted Amino Acids. Pept Sci. 2011. 2010. 135-135
平田貴之, 長野正展, 出水庸介, 栗原正明, 土井光暢, 田中正一, 末宗洋. 2つの異なる不斉中心を有する6員環状ジ置換アミノ酸の合成とそのペプチドの二次構造研究. 日本薬学会九州支部大会講演要旨集. 2010. 27th. 116

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Books (5)：

Mid-Sized Macrocyclic Peptides as a New Drug Modality
Springer Nature, 2021
ペプチドから「擬天然大環状ペプチド」へのモダリティーの拡張
有機合成化学協会誌 2020
抗体-薬物複合体における水溶性リンカーの重要性
ファルマシア-公益社団法人日本薬学会 2016
機能性大環状ポリペプチドの翻訳合成とRaPID探索
高分子-公益社団法人高分子学会 2014
未来を切り拓く特殊ペプチド創薬
ファルマシア-公益社団法人日本薬学会 2014

Education (3)：

2007 - 2010 九州大学大学院薬学府創薬科学専攻博士課程
2005 - 2007 Kyushu University Graduate School of Pharmaceutical Sciences
2000 - 2004 Daiichi University, College of Pharmaceutical Sciences Faculty of Pharmaceutical Sciences Course of Pharmaceutical Technology

Work history (5)：

2020/09 - 2023/04 The University of Tokyo Department of Art and Sciences
2013/01 - 2020/08 The University of Tokyo Graduate School of Chemistry Postdoc
2013/04 - 2016/03 日本学術振興会特別研究員(PD)
2010/04 - 2012/12 The Scripps Research Institute Department of Molecular Biology and Chemistry Research Associate
2007/04 - 2010/03 日本学術振興会特別研究員(DC1)

Association Membership(s) (6)：

THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN , JAPANESE SOCIETY FOR CHEMICAL BIOLOGY , The Japanese Peptide Society , 日本薬学会 , 日本化学会 , 日本化学会生体機能関連化学部会

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