Shinohara Nobuo

2020 - 2023 Impact of behavioral sexual dimorphism and fetal endocrinological status on establishment of bladder and bowel control in children

2018 - 2021 Development of an immunological monitoring system to predict chronic rejection in kidney transplant recipients.

2018 - 2021 Development of the new system to appropriately assess health related quality of life in patients with bladder cancer survivor using patient reported outcome.

2018 - 2021 Development of an algorithm for risk of chronic antibody-mediated rejection after kidney transplant assessed by human leukocyte antigen structure-based histocompatibility

2017 - 2020 Effects of prenatal exposure to endocrine disruption chemicals on gonadal function and sexual dimorphism

2017 - 2020 The control of castration resistant prostate cancer (CRPC) through degradation of androgen receptor splice variant by dioxins

2017 - 2020 Targeting urothelial cancer by inhibiting drug transporter of tumor blood vessels

2017 - 2020 Continuous training system for developing highly competent endoscopic surgeons

2014 - 2017 Development of "Ubiquitin" -targeted Prostate cancer treatment

2014 - 2017 Inhibition of prostatic cancer through degradation of androgen receptor by effects of dioxin receptor ligand

2014 - 2017 Prediction of cancer metastasis by tumor endothelial secreting proteins

2014 - 2017 Application of tumor endothelial derived exosomal-miRNA for cancer diagnosis and therapy.

2014 - 2017 Building the high-reliability surgical team by use of previous medical incidents reports

2011 - 2013 Development of novel therapy for refractory prostatic cancer through degradation of androgen receptor by effects of dioxins

2011 - 2013 Discovery of diagonositc and therapeutic biomarker by circulating tumor endothelial cells in metastatic renal cell carcinoma

2008 - 2010 Development of new screening system for anti-angiogenic drugs using tumor associated endothelial cells derived from renal cell carcinoma

2005 - 2006 In vivo imaging with replication competent retrovirus vector in urologic cancer

2005 - 2006 Analysis of Mechanism of Adrenal Regeneration

2003 - 2004 Analysis of expression pattern of the gene which is related to the radiation sensitivity in urothelial cancer and its clinical application

2001 - 2003 Elucidation of protective effects of phytochemicals on hormone-related cancer

2000 - 2001 Establishment of gene therapy against bladder cancer utilizing gelsolin gene and a dominant negative ras mutant

1999 - 2000 Basic study for the prevention of recurrence by inhibition of cell adhesion and migration in superficial bladder cancer.

1999 - 2000 Gene target therapy against human bladder cancer by gelsolin gene

1998 - 1999 Preclinical study for gene therapy against bladder cancer utilizing gelsolin gene and a dominant negative ras mutant

1996 - 1997 Growth suppression of renal cell carcinoma cell lines by a dominant negative H-ras mutant

1996 - 1997 Establishment of Method of Detecting Early Prostate Carcinoma by Classification of lsozyme Pattern of Prostate Specific Antigen.

1993 - 1993 ras癌遺伝子発現細胞におけるシスプラチン耐性機構と臨床への応用

1993 - 1993 シスプラチン耐性におけるras癌遺伝子の役割とその克服

泌尿器科癌に対する新規抗癌剤を用いた全身化学療法の開発

Development of systemic chemotherapy utilizing novel anti-cancer drugs against the urological cancers