Research theme for competitive and other funds (21)：
2022 - 2027 Development of oral antipruritic drugs by elucidating the spinal alloknesis circuitry
2023 - 2026 加齢によるかゆみの謎にせまる:末梢神経解析による難治性かゆみ誘発機序の解明
2022 - 2025 Development of human skin equivalent for atopic dermatitis with human iPS cells-derived sensory neurons: elucidation of mechanism of itch sensitivity
2020 - 2025 Elucidation of control mechanisms of itch targeting mu opioid receptors distributed in skin and development of novel antipruritic drugs
2020 - 2023 かゆみ過敏の治療に向けたアロネーシスの発症因子および調節機構の解明
2019 - 2022 アトピー性皮膚炎におけるセマフォリン3Aの発現変動機序の解明
2018 - 2021 Elucidation of the mechanisms of alloknesis (itch hypersensitivity) and development of treatment
2016 - 2019 Elucidation of mechanisms of peripheral itch hypersensitivity focusing on dorsal root ganglia and development for its therapeutic application
2015 - 2019 Role of epidermal osmotic pressure in dry skin induced itch
2016 - 2018 Effect of antimicrobial peptide cathelicidin on atopic dermatitis
2015 - 2018 Role of gastrointestinal hormone in itch of atopic dermatitis
2014 - 2016 A method to differentiate peripheral neurons mediating itch from human induced pluripotent stem cells
2013 - 2016 Elucidation of roles of spinal glial cells in intractable itch and development of antipruritic therapy
2013 - 2015 Investigation of the effect of excimer lamp on intraepidermal nerve fibers and its application to intractable pruritus
2013 - 2015 Elucidation of spinal itch transmitters and development of antipruritic therapy
2010 - 2012 難治性痒みの発生機序の解明と臨床応用への試み
2009 - 2011 A study of a novel allergic rhinitis treatment using nerve repulsion factor semaphorin 3A(Sema3A)
2010 - 2010 アトピー性皮膚炎における痒み神経の組織学的特性化と病態生理的役割
2008 - 2010 Elucidation of penetration mechanisms of sensory nerve fibers on a basement membrane in atopic dermatitis and application to intractable pruritus
2008 - 2009 Investigation of antipruritic effects in atopic dermatitis using nerve repulsion factor Sema3A
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Papers (91)：
Qiaofeng Zhao, Mitsutoshi Tominaga, Sumika Toyama, Eriko Komiya, Tomohiro Tobita, Motoki Morita, Ying Zuo, Kotaro Honda, Yayoi Kamata, Kenji Takamori. Effects of Psychological Stress on Spontaneous Itch and Mechanical Alloknesis of Atopic Dermatitis. Acta dermato-venereologica. 2024. 104. adv18685
Yayoi Kamata, Rui Kato, Mitsutoshi Tominaga, Sumika Toyama, Eriko Komiya, Jun Utsumi, Takahide Kaneko, Yasushi Suga, Kenji Takamori. Identification of keratinocyte cytoprotectants against toxicity by the multikinase inhibitor sorafenib using drug repositioning. JID Innovations. 2024
Toshiya Ebata, Yukihiro Ohya, Yusei Ohshima, Tsugunobu Andoh, Mitsutoshi Tominaga, Yoko Kataoka, Yoshinori Fukui, Nobuyuki Ebihara, Shunji Hasegawa, Shigetoshi Kobayashi, et al. [RECOMMENDATION FOR ITCH ASSESSMENT FROM THE ATOPIC ITCH CONSENSUS MEETING (AICOM)]. Arerugi = [Allergy]. 2024. 73. 2. 171-179
Tomoko Yoshimura, Seiji Kamijo, Saori Ichikawa, Toru Kimitsu, Yurie Masutani, Saya Shimizu, Keiko Takada, Takasuke Ogawa, Mitsutoshi Tominaga, Kenji Takamori, et al. Antigen protease activity with a detergent induces severe skin inflammation with itch and robust Th17/Th22 differentiation in mice. The Journal of investigative dermatology. 2023
Munehiro Tsurumachi, Yayoi Kamata, Mitsutoshi Tominaga, Junko Ishikawa, Tomoki Hideshima, Eri Shimizu, Takahide Kaneko, Yasushi Suga, Kenji Takamori. Increased production of natural moisturizing factors and bleomycin hydrolase activity in elderly human skin. Journal of dermatological science. 2023. 110. 1. 2-9
1996 - 2000 Tokyo University of Science Faculty of Industrial Science and Technology Biological Science and Technology
Professional career (2)：
Ph.D., Biological Engineering (Tokyo University of Science)
Ph.D., Medicine (Juntendo University)
Work history (9)：
2019/08 - 現在 Juntendo Itch Research Center (JIRC) Vice Director
2017/11 - 現在 Juntendo University Graduate School of Medicine
2014/02 - 2017/10 Juntendo University Graduate School of Medicine
2012/04 - 2014/01 Juntendo University Graduate School of Medicine
2011/04 - 2012/03 University of California, Davis Visiting Researcher
2010/04 - 2012/03 Juntendo University Graduate School of Medicine
2005/10 - 2010/03 Juntendo University Graduate School of Medicine
2005/04 - 2005/09 Juntendo University Graduate School of Medicine
Institute for Environment and Gender-Specific Medicine, Juntendo University Graduate School of Medicine Associate Professor
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Committee career (3)：
2023/11 - 現在 International Forum for the Study of Itch (IFSI) Board member
2018/05 - 現在 The Japanese Society for Investigative Dermatology Councilor
2018/05 - 現在 日本研究皮膚科学会 評議員
Awards (21)：
2022 - 日本研究皮膚科学会第47回年次学術大会 研究助成
2022 - 大塚製薬 研究助成
2021 - 日本研究皮膚科学会 第46回年次学術大会・総会 3 minutes presentation Award
2021 - 公益財団法人コーセーコスメトロジー研究財団 コスメトロジー研究助成
2021 - 一般財団法人リディアオリリー記念ピアス皮膚科学振興財団 公募課題研究助成
2020 - マルホ奨学寄付支援プログラム
2019 - サノフィ研究・教育支援
2019 - ノバルティス研究助成
2018 - 一般財団法人リディアオリリー記念ピアス皮膚科学振興財団 指定課題研究助成金
2017 - The Japan Dermatological Association Most Cited Paper in 2016
2017 - The Japan Dermatological Association Most Cited Paper in 2016
2017 - 日本リディアオリリー協会 研究助成
2016 - The Japan Dermatological Association Most Cited Paper in 2015
2016 - 公益財団法人 LIXIL住生活財団 LIXIL住生活財団調査研究助成
2015 - The Japan Dermatological Association Most downloaded paper in 2014
2014 - 公益財団法人 猪之鼻奨学会 猪之鼻奨学研究助成
2010 - 加齢皮膚医学研究会 ロート賞
2010 - 日本病態プロテアーゼ学会 奨励賞
2010 - 日本皮膚アレルギー・接触皮膚炎学会 研究部門 最優秀論文賞
2009 - 財団法人土屋文化振興財団 医学研究奨励賞
2008 - 財団法人柏戸記念財団 医学研究奨励賞
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Association Membership(s) (8)：
JAPANESE SOCIETY OF ALLERGOLOGY
, 日本病態プロテアーゼ学会
, International Forum for the Study of Itch
, Society for Neuroscience
, THE JAPAN NEUROSCIENCE SOCIETY
, THE JAPANESE DERMATOLOGICAL ASSOCIATION
, THE JAPANESE SOCIETY FOR INVESTIGATIVE DERMATOLOGY
, Japanese Association of Geriatric Dermatology Research
