Iwabuchi Kuniyoshi

イワブチクニヨシ | Iwabuchi Kuniyoshi

Affiliation and department：
Job title： Professor

Research keywords (8)： Apoptosis , DNA repair , Cell cycle checkpoints , 53BP2 , 53BP1 , p53 , 細胞周期 , p53結合タンパク質の機能とDNA修復

Research theme for competitive and other funds (12)：

2021 - 2023 放射線誘発アポトーシス細胞に見られる細胞膜表層へのヌクレオソーム露出の機序解明
2021 - 2021 DNA修復因子53BP1を標的とした効果的な化学療法モデルの探索
2018 - 2020 53BP1の生体維持機構:DNA損傷修復からアポトーシス細胞への免疫寛容誘導まで
2015 - 2017 アポトーシス細胞におけるクロマチンの細胞表層露出のメカニズム解明
2014 - 2016 DNA修復蛋白質53BP1の細胞表層への露出とアポトーシス細胞の腫瘍免疫原性獲得

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Papers (63)：

Ryo Sakasai, Tadashi Matsui, Yumi Sunatani, Kuniyoshi Iwabuchi. UbcH5c-dependent activation of DNA-dependent protein kinase in response to replication-mediated DNA double-strand breaks. Biochemical and Biophysical Research Communications. 2023. 668. 42-48
(Bhushan L Thakur), Adrian M Baris, Haiqing Fu, Christophe E Redon, Lorinc S Pongor, Sara Mosavarpour, Jacob M Gross, Sang-Min Jang, Robin Sebastian, Koichi Utani, Lisa M Jenkins, Fred E Indig, and Mirit I Aladjem. Convergence of SIRT1 and ATR signaling to modulate replication origin dormancy. Nucleic Acids Research. 2022. 50. 9. 5111-5128
Ryo Sakasai, Mitsuo Wakasugi, Tadashi Matsui, Yumi Sunatani, Masafumi Saijo, Tsukasa Matsunaga, Kuniyoshi Iwabuchi. Camptothecin compromises transcription recovery and cell survival against cisplatin and ultraviolet irradiation regardless of transcription-coupled nucleotide excision repair. DNA repair. 2022. 113. 103318-103318
Teppei Shibata, Masahito Ikawa, Ryo Sakasai, Yasuhito Ishigaki, Etsuko Kiyokawa, Kuniyoshi Iwabuchi, Dhirendra P. Singh, Hiroshi Sasaki, Eri Kubo. Lens-specific conditional knockout of tropomyosin 1 gene in mice causes abnormal fiber differentiation and lens opacity. Mechanisms of Ageing and Development. 2021. 196. 111492
Asuka Watanabe, Misa Togi, Terutsugu Koya, Makoto Taniguchi, Takuya Sakamoto, Kuniyoshi Iwabuchi, Tomohisa Kato, Shigetaka Shimodaira. Identification of CD56 dim subpopulation marked with high expression of GZMB/PRF1/PI-9 in CD56 + interferon-α-induced dendritic cells. Genes to Cells. 2021. 26. 5. 313-327

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Lectures and oral presentations (111)：

DNA複製を介したDNA二本鎖切断の修復機構とその破綻による核の断片化
(第96回日本生化学会大会 2023)
糖尿病性腎症と糸球体内VI型膠原繊維(COL6)の蓄積に関する検討
(第33回日本糖尿病性腎症研究会 2022)
53BP1- and BRCA2-dependent biphasic repair of replication-mediated one-ended DNA double-strand breaks DNA 複製を介した one-end DNA 二本鎖切断の 53BP1 と BRCA2 による二相性修復
(日本放射線影響学会第65回大会 2022)
Camptothecin compromises transcription recovery and cell survival against cisplatin
(2021)
ヒト糸球体内皮細胞DNA損傷によるVI型コラーゲン分泌機序の解明
(金沢医科大学医学会第56回学術集会 2021)

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Professional career (1)：

Medical doctor

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