Osafune Kenji

オサフネケンジ | Osafune Kenji

Affiliation and department：
Job title： Professor
Homepage URL (2)： https://www.cira.kyoto-u.ac.jp/j/research/osafune_summary.html , http://www.osafune.icems.kyoto-u.ac.jp/

Research field (1)： Nephrology

Research keywords (5)： Regeneration , iPS cell , Kidney , Pancreas , liver

Research theme for competitive and other funds (2)：

2008 - 2012 ヒトiPS細胞を用いた腎臓再生医療の開発
2008 - 2012 Development of regenerative medicine for kidney disease with iPS cell

Papers (91)：

Hiraku Tsujimoto, Azusa Hoshina, Shin-Ichi Mae, Toshikazu Araoka, Wang Changting, Yoshihiro Ijiri, May Nakajima-Koyama, Satoko Sakurai, Kazusa Okita, Ken Mizuta, et al. Selective induction of human renal interstitial progenitor-like cell lineages from iPSCs reveals development of mesangial and EPO-producing cells. Cell Reports. 2024. 43. 2. 113602
Shin-Ichi Mae, Fumihiko Hattanda, Hiroyoshi Morita, Aya Nozaki, Naoko Katagiri, Hanako Ogawa, Kaori Teranaka, Yu Nishimura, Aoi Kudoh, Sanae Yamanaka, et al. Human iPSC-derived renal collecting duct organoid model cystogenesis in ADPKD. Cell Reports. 2023. 42. 12. 113431
Hasan Al Reza, Zishaan Farooqui, Abid Al Reza, Callen Conroy, Kentaro Iwasawa, Yasuhiro Ogura, Keisuke Okita, Kenji Osafune, Takanori Takebe. Synthetic augmentation of bilirubin metabolism in human pluripotent stem cell-derived liver organoids. Stem Cell Reports. 2023. 18. 11. 2071-2083
Ryuichiro Hirayama, Kosuke Toyohara, Kei Watanabe, Takeya Otsuki, Toshikazu Araoka, Shin-Ichi Mae, Tomoko Horinouchi, Tomohiko Yamamura, Keisuke Okita, Akitsu Hotta, et al. iPSC-derived type IV collagen α5-expressing kidney organoids model Alport syndrome. Communications Biology. 2023. 6. 1. 854
Naoki Ishiguro, Etsushi Takahashi, Hiroshi Arakawa, Asami Saito, Fumihiko Kitagawa, Masayuki Kondo, Gaku Morinaga, Masahito Takatani, Ryo Takahashi, Takashi Kudo, et al. Improvement of Protein Expression Profile in Three-Dimensional Renal Proximal Tubular Epithelial Cell Spheroids Selected Based on OAT1 Gene Expression: A Potential In Vitro Tool for Evaluating Human Renal Proximal Tubular Toxicity and Drug Disposition. Drug Metabolism and Disposition. 2023. 51. 9. 1177-1187

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MISC (223)：

前田貴広, 長船健二. 再生医療膵β細胞再生研究の現状と展望. 小児・思春期糖尿病コンセンサス・ガイドライン2024. 2024
Azuma Kimura, Kenji Osafune. The Promises of Pancreatic Progenitor Proliferation and Differentiation. Pluripotent Stem Cell Therapy for Diabetes. 2024. 85-93
前伸一, 長船健二. 腎臓オルガノイドを用いた創薬研究の進歩と展望. 日腎会誌2023. 2023. 65. 8. 923-929
清水達也, 山縣邦弘, 長船健二. 腎オルガノイドを用いた多発性嚢胞腎モデル解析. 腎臓内科 (科学評論社). 2023. 17. 6. 642-649
長船健二. 腎オルガノイドを用いた研究展望. 腎臓内科 (科学評論社). 2023. 17. 6. 627-633

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Books (1)：

もっとよくわかる!幹細胞と再生医療
羊土社 2014

Lectures and oral presentations (428)：

「iPS細胞による1型糖尿病根治」
(日本IDDMネットワークサイエンスフォーラム in 大阪)
臓器再生のフロンティア「iPS 細胞を用いた腎、膵、肝疾患に対する再生医療と新規治療薬の開発」
(第 96 回日本内分泌学会学術総会特別シンポジウム3 2023)
“Liver Regeneration Using iPSC in Liver Cirrhosis”
(The Liver Week 2023 2023)
iPSC technology-based regenerative medicine”
(2023)
“iPSC-based regenerative therapies for kidney diseases and diabetes”
(A*CGT Symposium 2023 2023)

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Work history (11)：

2024/04 - 現在 Center for iPS Cell Research and Application, Kyoto University Deputy Director
2022/04 - 現在 Center for iPS Cell Research and Application, Kyoto University Department of Cell Growth and Differentiation Department Head
2014/10 - 現在 Center for iPS Cell Research and Application, Kyoto University Professor
2010/04 - 2014/09 Center for iPS Cell Research and Application, Kyoto University Associate Professor
2008/06 - 2010/03 Japan Science and Technology Agency PRESTO Research Fellow

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Association Membership(s) (9)：

日本内分泌学会 , 日本内科学会 , International Society of Differentiation , International Society for Stem Cell Research , American Society of Nephrology , Japan Diabetes Society , Japanese Society for Regenerative Medicine , Japanese Society for Dialysis Therapy , Japanese Society of Nephrology

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