Rchr
J-GLOBAL ID：200901043417541860
Update date: Apr. 24, 2024
Tamai Ikumi
タマイ イクミ | Tamai Ikumi
Affiliation and department：
Homepage URL (1)：
http://dmpkatku.jp/
Research field (1)：
Clinical pharmacy
Research keywords (9)：
トランスポーターの生理・病態作用機構
, 医薬品の消化管吸収
, 食品の生体作用機構
, 血清尿酸調節機構
, DFI
, DDI
, Pharmacokinetics
, 薬物トランスポーター
, Drug Transporter
Research theme for competitive and other funds (57)：
- 2022 - 2026 細胞内レドックス制御を司るがん幹細胞治療の標的トランスポーター画像診断薬の開発
- 2023 - 2025 尿酸結合タンパク質CD38を介した尿酸による炎症応答調節
- 2021 - 2025 ナトリウム共役能動輸送型糖輸送体を標的としたセラノスティクス薬剤の開発
- 2021 - 2024 A search of novel genes involved in spermatogenesis failure of Down syndrome model mice
- 2021 - 2024 血清尿酸値を感受する尿酸センサーの同定と生理作用
- 2020 - 2024 Quantitative Prediction of Oral Drug Absorption by Kinetically Analyzing Gastrointestinal Water Dynamics
- 2020 - 2022 Regulation of intestinal function via microRNA from fruit-derived microvesicles
- 2018 - 2021 Molecular mechanism of organelle positioning and flagellar formation regulated by cell adhesion molecule
- 2016 - 2020 Drug-food interaction on transporters
- 2016 - 2018 Micro RNA-mediated expressional regulation of transporters
- 2015 - 2018 Development of high accuracy multidrug resistance prediction method using SPECT imaging for individualized anticancer therapy
- 1985 - 2018 薬物動態と関連するトランスポーターに関する研究
- 2015 - 2017 Development strategy of tumor diagnostic agent by system upregulated functional biomolecule based on expression analysis of tumor associated transporter
- 2013 - 2017 Development of a molecular targeted radiolabeled diagnostic agent useful for personalized drug therapy of psychoneurotic diseases
- 2014 - 2016 Local drug-drug interaction of donepezil with cilostazol at BCRP transporter
- 2013 - 2016 Chemical biology of MDR cancer selective cytotoxicity using natural product derivatives
- 2013 - 2015 Impact of transporters for uptake of estrogen precursors on progression of breast cancer cells
- 2012 - 2015 The design strategy for tumor diagnostic agents utilizing the functional biomolecule expression system based on gene expression analysis of tumor cells
- 2012 - 2014 Exploration of association mechanism between hyperuricemia and insulin resistance
- 2011 - 2013 New rational for chemotherapy targeting transporters expressed in cancer stem cells
- 2011 - 2013 Regional Difference in the Effect of Influx/Efflux Transporters and Metabolic Enzymes on Intestinal Drug Absorption
- 2011 - 2012 Application of Sandwich-cultured hepatocytes for analysis of drug-drug interaction on bile canalicular transporters
- 2009 - 2011 The probe design strategy of post-FDG tumor diagnostic agents based on the functional biomolecule expression analysis of human cultured cells
- 2009 - 2011 Manipulation of gastrointestinal functions by polymeric conjugates bearing glucosides, oral anti-diabetic drugs
- 2009 - 2011 Clarification and evaluation of regulation mechanism of uric acid
- 2009 - 2010 Evaluation of molecular mechanisms of tumor-specific protoporphyr in accumulation induced by 5-aminolevulinic acid
- 2009 - 2010 細胞内オルガネラ膜トランスポーター活性の定量的可視化による薬物の細胞毒性評価
- 2007 - 2008 The mechanism and its inter-individual variability of the Blood-Brain Barrier penetration of anti-influenza drug, oseltamivir
- 2007 - 2008 Species difference in hepatic disposition of organic anions
- 1985 - 2007 Membrane transporters involved in drug absorption and disposition
- 2005 - 2006 トランスポーター発現プロファイルに基づく細胞分化・増殖制御手法
- 2005 - 2006 Establishment of Novel Anti-Hormone Therapy of Breast Cancer based on the Inhibition of Uptake Transporter of Conjugated Estrogen by Cancer Cells.
- 2003 - 2004 トランスポーターを応用したインテリジェントDDSによる癌分子標的治療
- 2003 - 2004 Development of Gene Therapy with Nanotechnology derived Intelligent Drug Deliver Systems
- 2003 - 2004 Drug Toxicity Induced by Alteration of Transporter Activity
- 2002 - 2003 アンチセンス発現アデノウイルスを用いたトランスポーターの薬物体内動態制御機能評価
- 2001 - 2003 Molecular Targeting Therapy with Intelligent Drug Delivery System using Transporter
- 2001 - 2002 STUDIES FOR THE MECHANISM OF MULTIPLICITY IN SUBSTRATE SPECIFICITY OF TRANSPORTERS.
- 2001 - 2002 ゼノバイオティックスの取り込みと排出輸送がシンクロナイズした生体防御機構
- 2000 - 2002 Drug Delivery based on Multiplicity of Various Membrane Transporters
- 2000 - 2001 Evaluation of the blood-brain barrier based on the functional analysis of transporters using newly developed techniques.
- 2000 - 2001 Delivery of peptide-mimetic drugs to tumors utilizing oligopeptide transporters
- 2000 - 2000 トランスポーター発現アデノウイルスベクターを用いたペプチド様抗がん剤の脳腫瘍送達
- 1999 - 2000 Functional characterization and relevance of carnitine transporter OCTN2 to secondary carnitine deficiency.
- 1999 - 2000 ゼノバイオティックス取り込み・排出輸送と化学変換がシンクロナイズした生体防御機構
- 1999 - 1999 薬物トランスポーター群の分子認識・輸送の多様性の解明とその創薬への応用
- 1998 - 1998 薬物相互作用による血液脳関門輸送系・排出ポンプ機能修飾と薬物中枢移行変動
- 1997 - 1998 Molecular mechanism of blood-brain barrier transport of drugs.
- 1996 - 1997 Evaluation of disease model traits in cultured cells derived from carnitine deficient JVS mice
- 1996 - 1996 モノカルボン酸輸送系の組織特異的機能発現とドラッグテリバリーへの応用
- 1995 - 1996 Blood-brain barrier functioning as dynamic interface and drug delivery to the brain
- 1995 - 1995 外来性遺伝子発現系を用いた小腸上皮薬物担体輸送機構の解明
- 1994 - 1994 小腸上皮薬物担体輸送の分子機構論的解明と薬物の経口デリバリーへの応用
- 1994 - 1994 P-糖蛋白質の血液脳関門機能解明と薬物脳移行制御法の開発
- 1992 - 1993 Clarification of transcellular transport mechanism of drugs utilizing tissue cultured cell systems
- 1992 - 1992 アフリカツメガエル卵母細胞発現系を用いた薬物輸送機構の分子論的解析
- 1986 - 1987 Quantitative analysis of factors determining age-related change in tissue distribution of animicrobial agents
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Papers (487)：
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Rikako Imamura, Masahiro Sugimoto, Shin-ichi Horike, Jumpei Terakawa, Kazuki Fujita, Ikumi Tamai, Takiko Daikoku, Yukio Kato, Hiroshi Arakawa. Role of organic anion transporter NPT4 in renal handling of uremic toxin 3-indoxyl sulfate. Journal of Pharmaceutical Sciences. 2024
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Shijie Wen, Hiroshi Arakawa, Ikumi Tamai. Uric acid in health and disease: From physiological function to pathogenic mechanism. Pharmacology & therapeutics. 2024. 108615-108615
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Miyuki Takemura, Katsuhisa Inoue, Ikumi Tamai, Yoshiyuki Shirasaka. Magnitude of Fruit Juice-Drug Interactions Due to Osmolality-Dependent Fluid Secretion: Differences among Apple, Orange, and Grapefruit Juices. Biological and Pharmaceutical Bulletin. 2024. 47. 1. 72-78
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Yugo Yasugi, Yoshiyuki Shirasaka, Ikumi Tamai. Quantitative analysis of the impact of membrane permeability on intestinal first-pass metabolism of CYP3A substrates. Biopharmaceutics & Drug Disposition. 2023
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Koyomi Sumiya, Miho Shogenji, Yasunori Ikenaga, Yoru Ogawa, Kohei Hirako, Arimi Fujita, Tsutomu Shimada, Masako Hashimoto, Akio Masuda, Takehito Nagamoto, et al. Association between switching prescribed drugs for lower urinary tract symptoms and independence of urination in post-stroke patients: A retrospective cohort study. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 2023. 32. 12. 107419-107419
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MISC (81)：
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Nakamura Yoshinobu, Nakanishi Takeo, Shimada Hiroaki, Tamai Ikumi. RELEVANCE OF PROSTAGLANDIN TRANSPORTER (PGT) TO PGE(2) SECRETION FROM MACROPHAGES IN RESPONSE TO INFLAMMATORY STIMULATION. DRUG METABOLISM REVIEWS. 2015. 47. 288
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Role of Transporters in Pulmonary Disposition of Drugs and Endogenous Compounds. 2015. 44. 1. 38-46
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奥平宏之, 岡俊太郎, 中西猛夫, 小林正和, シャスター デービッド, グッドマン マーク, 玉井郁巳, 川井恵一, 白神宜史. 前立腺癌へのtrans-1-amino-3-18F-fluorocyclobutanecarboxylic acid(anti-18F-FACBC)の輸送機序. 日本DDS学会学術集会プログラム予稿集. 2014. 30th
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Arakawa Hiroshi, Nakanishi Takeo, Shirasaka Yoshiyuki, Tamai Ikumi. Upregulation of organic anion-transporting polypeptide (OATP) 1A2 by depletion of androgens; a possible molecular mechanism of castration resistance in prostate cancer. DRUG METABOLISM REVIEWS. 2011. 43. 23
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Shichiri Megumi, Shirasaka Yoshiyuki, Mori Takanori, Nakanishi Takeo, Tamai Ikumi. Differential interaction of fruit juices with transporter-mediated absorption of drugs. DRUG METABOLISM REVIEWS. 2011. 43. 54
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Books (9)：
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新薬剤学 改訂第2版
株式会社南江堂 2007
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製剤学 改訂第5版
株式会社南江堂 2007
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最新創薬学2007 ー薬物動態学特性の解析は創薬のキーワードー
株式会社メディカルドゥ 2007
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生物薬剤学 改訂第2版
株式会社南江堂 2007
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創薬動態 医薬品創製のための考えかたと最新情報
日本薬物動態学会 2006
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Lectures and oral presentations (21)：
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フルオロキノロンとNSAIDsの薬物間相互作用におけるOAT3の関与
(トランスポーター研究会・第1回関東部会 2007)
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OATP分子を介したβlactam抗生物質の肝移行のラット/ヒト間比較
(第29回生体膜と薬物相互作用シンポジウム 2007)
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有機アニオントランスポーターを介したキノロン系抗菌薬の体内動態特性
(第29回生体膜と薬物の相互作用シンポジウム 2007)
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尿酸トランスポーター活性と血清尿酸値変動
(第29回生体膜と薬物の相互作用シンポジウム 2007)
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リン酸オセルタミビルの中枢移行過程におけるP-糖蛋白質の関与
(第29回生体膜と薬物の相互作用シンポジウム 2007)
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Education (5)：
- 1988 - 現在 薬学博士(東京大学)
- - 1982 Kanazawa University Faculty of Pharmaceutical Sciences
- - 1982 Kanazawa University Faculty of Pharmaceutical Science
- Kanazawa University
- Kanazawa University Graduate School, Division of Pharmaceutical Sciences
Professional career (1)：
- Ph.D (The University of Tokyo)
Work history (12)：
- 2008 - 現在 Kanazawa University Institute of Medical, Pharmaceutical and Health Sciences
- 2002 - 2008 Tokyo University of Science Faculty of Pharmaceutical Sciences
- 1996 - 2002 Kanazawa University Faculty of Pharmaceutical Sciences
- 1996 - 2002 : Associate Protessor, Kanazawa University,
- 2002 - -: - Protessor, Tokyo University of Sience Faculty of
- 1992 - 1996 Kanazawa University Faculty of Pharmaceutical Sciences
- 1986 - 1992 Kanazawa University Faculty of Pharmaceutical Sciences
- 1990 - 1991 米国ミシガン大学 薬学部 Research Associate
- 1989 - 1990 米国シカゴ大学 医学部 Research Associate
- 1982/09 - 1986/03 Kanazawa University Faculty of Pharmaceutical Sciences
- Pharmalntiol Science
- Faculty of Pharmalntiol Science
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Committee career (18)：
- 2017 - 現在 Pharmaceutical Research Editor
- 2017 - 現在 日本薬物動態学会 理事
- 2016 - 現在 米国実験薬理学会ASPET Drug Metabolism & Disposition, EAB
- 2008 - 現在 Biopharmaceutics & Drug Disposition Associate Editor
- 2007 - 現在 内閣府 食品安全委員会専門委員
- 2002 - 現在 米国薬学会 Pharmaceutical Research誌Editorial board
- 2002 - 現在 Molecular Pharmaceutics誌 Editorial board
- 2002 - 現在 Journal Pharmaceutical Science誌 Editorial board
- 2002 - 現在 日本薬物動態学会 評議委員
- 2001 - 現在 日本薬剤学会 評議委員
- 2019/02 - Japanese Society of Gout and Uric & Nucleic Acids Councilar
- 2010 - 2013 Drug Metabolism & Pharmacokinetics Editor in Chief
- 2010 - 2013 国際薬物動態学会ISSX 理事Councilor
- 2006 - 2013 日本薬物動態学会 理事
- 2006 - 2008 日本薬学会 Biological Pharmaceutical Bulletin誌編集委員
- 2004 - 2008 国際薬物動態学会 国際薬物動態学会ISSX Membership Affair Committee
- 2004 - 2005 国際薬物動態学会(ISSX) ISSX Membership Affair Committee 委員
- 2002 - 2005 日本薬物動態学会 DMPK誌ニュースレター編集委員長
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Awards (4)：
- 2013 - 日本薬物動態学会 日本薬物動態学会賞
- 2003 - ISSX New Investigator Award 2003
- 1998 - 1998 日本薬物動態学会 奨励賞
- 1998 - 1998 Japanese Society for the Study of Xemobiotics, Young Inrestigathe Award
Association Membership(s) (7)：
JAPANESE SOCIETY OF GOUT AND URIC & NUCLEIC ACIDS
, 米国実験薬理学会ASPET
, 米国薬学会AAPS
, 日本薬物動態学会
, 日本薬学会
, 国際薬物動態学会(ISSX)
, 日本薬剤学会
