2016 - 2019 Molecular epidemiological analysis for methicillin-resistant Staphylococcus aureus (MRSA) isolated in the hospitals in Kure District, Hiroshima
2006 - 2007 Analysis of Maturation pathway protein toxin of Enteric Bacteria and Studies of Prevention of Diarrhea
2004 - 2005 Analysis of secretion and maturation pathway of bacterial proteintoxin and its application to clinical study
2003 - 2005 Studies on proteins involved in synergistic up-regulation of apoptosis-related genes
2002 - 2004 Functional Studies of Escherichia coli Outer Membrane Protein TolC
2002 - 2003 Studies on the secretion and maturation pathway of bacterial exotoxin
2000 - 2001 Analysis of the process outer membrane of Escherichia coli heat-stable enterotoxin I passing through the outer membrane
1999 - 2001 Studies on the Processes of Construction of Active Structure of Bacterial Enterotoxin and of the Secretion to Milieu
1998 - 1999 Secretion mechanism of Escherichia coli heat0stbale enterotoxin I across the outer membrane
1997 - 1998 Analysis of Maturation Pathway of Heat-Stable Enterotoxin of Escherichia coli
1996 - 1996 大腸菌耐熱性エンテロトキシンIIの活性発現機序の解析
1996 - 1996 大腸菌耐熱性エンテロトキシンIの外膜通過機構の解析
1995 - 1995 大腸菌耐熱性エンテロトキシンIIのジスルフィド結合の形成とレセプターの解析
1995 - 1995 大腸菌耐熱性エンテロトキシンIの外膜通過機構
1994 - 1994 大腸菌耐熱性下痢原因毒素のジスルフィド結合形成の分子論的研究
1994 - 1994 大腸菌耐熱性下痢原因毒素Iの分泌とプロセッシング
1993 - 1993 大腸菌耐熱性下痢原因毒素IIの構造と作用機序に関する研究
1993 - 1993 大腸菌耐熱性下痢原因毒素Iのプロ領域の機能と構成アミノ酸
1992 - 1992 大腸菌耐熱性下痢原因毒素IIの活性と構造に関する研究
1991 - 1991 大腸菌耐熱性下痢原因毒素の分泌機序の分子論的研究
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Papers (58)：
Ryuto Maeda, Hidetomo Kobayashi, Mami Higashidani, Tetsuaki Matsuhisa, Akihiro Sawa, Katsushi Miyake, Yoshitaka Tayama, Kouji Kimura, Hiroyuki Itoh, Taichi Okano, et al. Molecular epidemiological and pharmaceutical studies of methicillin-resistant Staphylococcus aureus isolated at hospitals in Kure City, Japan. Access Microbiology. 2022. 4. 2. 000319-000319
Mitsunobu Ueda, Hidetomo Kobayashi, Soshi Seike, Eizo Takahashi, Keinosuke Okamoto, Hiroyasu Yamanaka. Aeromonas sobria Serine Protease Degrades Several Protein Components of Tight Junctions and Assists Bacterial Translocation Across the T84 Monolayer. Frontiers in Cellular and Infection Microbiology. 2022. 12. 824547-824547
Soshi Seike, Hidetomo Kobayashi, Mitsunobu Ueda, Eizo Takahashi, Keinosuke Okamoto, Hiroyasu Yamanaka. Outer membrane vesicles released from Aeromonas strains are involved in the biofilm formation. Frontiers in microbiology. 2020. 11. 613650-613650
Hidetomo Kobayashi, Soshi Seike, Masafumi Yamaguchi, Mitsunobu Ueda, Eizo Takahashi, Keinosuke Okamoto, Hiroyasu Yamanaka. Aeromonas sobria serine protease decreases epithelial barrier function in T84 cells and accelerates bacterial translocation across the T84 monolayer in vitro. PLOS ONE. 2019. 14. 8. e0221344-e0221344
Hidetomo Kobayashi, Tadamune Otsubo, Fumiteru Teraoka, Kiyoshi Ikeda, Soshi Seike, Eizo Takahashi, Keinosuke Okamoto, Toru Yoshida, Hideaki Tsuge, Hiroyasu Yamanaka. Involvement of the Arg(566) residue of Aeromonas sobria serine protease in substrate specificity. PLOS ONE. 2017. 12. 10
高橋 栄造, 越智 定幸, 西村 莉彩, 小池 和輝, 磯部 隆史, 埴岡 伸光, 小林 秀丈, 清家 総史, 山中 浩泰, 岡本 敬の介. Aeromonas sobriaセリンプロテアーゼ遺伝子の発現調節因子の同定(Identification of regulatory protein on production of serine protease by Aeromonas sobria). 日本細菌学雑誌. 2023. 78. 1. 90-90
小林 秀丈, 清家 総史, 高橋 栄造, 岡本 敬の介, 山中 浩泰. Aeromonasセリンプロテアーゼによるタイトジャンクションの破壊は菌の感染により増強される(Disruption of tight junction by Aeromonas serine protease is enhanced by the presence of bacteria). 日本細菌学雑誌. 2023. 78. 1. 91-91
