Hashimoto Hiroshi

ハシモトヒロシ | Hashimoto Hiroshi

Affiliation and department：
Other affiliations (2)：

Research field (2)： Pharmaceuticals - analytical and physicochemistry , Structural biochemistry

Research keywords (1)： Structural Biology

Research theme for competitive and other funds (41)：

2023 - 2026 Structural basis for stimulation of DNA damage checkpoint by 9-1-1 interacting protein RHINO
2022 - 2025 疾患関連抗体に対する抗イディオタイプDNAアプタマーのファスト&ファインデザイン
2020 - 2024 脊椎動物の染色体凝縮を担うコンデンシンの構造基盤と動的挙動の解明
2019 - 2022 Creation of antibody specific nucleic acid aptamers and their application to bio- process- and clinical analyses
2017 - 2021 Structural basis of HEAT-kleisin interactions in the condensin I subcomplex

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Papers (114)：

Kodai Hara, Kensuke Tatsukawa, Kiho Nagata, Nao Iida, Asami Hishiki, Eiji Ohashi, Hiroshi Hashimoto. Structural basis for intra- and inter-molecular interactions on RAD9 subunit of 9-1-1 checkpoint clamp implies functional 9-1-1 regulation by RHINO. The Journal of biological chemistry. 2024. 105751-105751
Hara K, Hishiki A, Hoshino T, Nagata K, Iida N, Sawada Y, Ohashi E, Hashimoto H. The 9-1-1 DNA clamp subunit RAD1 forms specific interactions with clamp loader RAD17, revealing functional implications for binding-protein RHINO. The Journal of biological chemistry. 2023. in press. 4. 103061-103061
Asami Hishiki, Sumire Okazaki, Kodai Hara, Hiroshi Hashimoto. Crystal structure of the sliding DNA clamp from the Gram-positive anaerobic bacterium Clostridioides difficile. Journal of biochemistry. 2022. 173. 1. 13-20
Hiroshi Hashimoto, Kodai Hara, Asami Hishiki. Structural basis for molecular interactions on the eukaryotic DNA sliding clamps PCNA and RAD9-RAD1-HUS1. Journal of biochemistry. 2022. 172. 4. 189-196
Taro Saito, Yutaka Shimizu, Kaori Tsukakoshi, Koichi Abe, Jinhee Lee, Kinuko Ueno, Ryutaro Asano, Brian V Jones, Tomohiro Yamada, Tatsuki Nakano, et al. Development of a DNA aptamer that binds to the complementarity-determining region of therapeutic monoclonal antibody and affinity improvement induced by pH-change for sensitive detection. Biosensors & bioelectronics. 2022. 203. 114027-114027

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MISC (27)：

達川絢介, 橋本博, 高橋達郎, 大橋英治. Roles of the ring structure of 9-1-1checkpoint clamp. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
Ryo Miyata, Muhamad Sahlan, Yoshinobu Ishikawa, Hiroshi Hashimoto, Sari Honda, Shigenori Kumazawa. Propolis Components from Stingless Bees Collected on South Sulawesi, Indonesia, and Their Xanthine Oxidase Inhibitory Activity (vol 82, pg 205, 2019). JOURNAL OF NATURAL PRODUCTS. 2020. 83. 4. 1356-1356
玉舟亮太, 飯田奈央, 原幸大, 原幸大, 櫻井ひとみ, 石川吉伸, 石川吉伸, 大橋英治, 菱木麻美, 菱木麻美, et al. Interaction analysis between 9-1-1 and RHINO in ATR-CHK1 checkpoint pathway. 量子ビームサイエンスフェスタ(Web). 2020. 2019
原幸大, 橋本博. 染色体凝縮を担うコンデンシンIサブコンプレックスの構造. 月間「アグリバイオ」. 2019. 3. 13. 1265-1267
原幸大, 橋本博. 染色体凝縮を担うコンデンシンIサブコンプレックスの構造. 月間「細胞」. 2019. 51. 12. 604-605

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Books (3)：

Lectures and oral presentations (49)：

Structural basis for molecular interactions of PCNA, a scaffold protein in DNA replication and repair
(2019)
Structural studies on DNA damage tolerance
(1st international symposium on Interdisciplinary Approaches to Integrative Understanding of Biological Signaling 2019)
Structural study of VHS domain of UVSSA
(2018)
Structural basis for novel interactions between human translesion synthesis polymerases and PCNA
(The Joint 2nd Pacific Rim International Conference on Protein Science and 4th Asian-Oceania Human Proteome Organization 2008)
ヒトREV7 及びMAD2 タンパク質の結合モチーフ配列の部分的オーバーラッピング
(BMB2008 2008)

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Education (5)：

Professional career (1)：

Work history (2)：

2013/04 - 現在 University of Shizuoka School of Pharmaceutical Sciences
2005/04 - 2007/03 Yokohama City University International Graduate School of Arts and Sciences

Committee career (9)：

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Association Membership(s) (4)：

日本生化学会 , 日本生物物理学会 , 日本結晶学会 , THE PHARMACEUTICAL SOCIETY OF JAPAN

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