Kawashima Etsuko

• 1999 - 遺伝子に作用する医薬品の開発
• 核酸と医薬品との分子関相互作用の解析
• 安定同 体標識ヌクレオシド類の効率的合成法の開発
• Study on the elucidation of mechanism of intermolecular recognition between nucleic acid and medicine
• Study on the effective synthesis of stableisotope labeled Nucleosides
The development of the medicine which affects the gene.

• K Kamaike, Y Kayama, M Isobe, E Kawashima. Efficient synthesis of [2-N-15]Guanosine and 2 '-deoxy[2 '-N-15]Guanosine derivatives using N-(tert-butyldimethylsilyl)[N-15]phthalimide as a N-15-labeling reagent. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS. 2006. 25. 1. 29-35
• K Kamaike, Y Kayama, M Isobe, E Kawashima. Efficient synthesis of [2-N-15]Guanosine and 2 '-deoxy[2 '-N-15]Guanosine derivatives using N-(tert-butyldimethylsilyl)[N-15]phthalimide as a N-15-labeling reagent. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS. 2006. 25. 1. 29-35
• M Ohnuma, Y Terui, M Tamakoshi, H Mitome, M Niitsu, K Samejima, E Kawashima, T Oshima. N-1-aminopropylagmatine, a new polyamine produced as a key intermediate in polyamine biosynthesis of an extreme thermophile, Thermus thermophilus. JOURNAL OF BIOLOGICAL CHEMISTRY. 2005. 280. 34. 30073-30082
• Stabilization of nucleic acids by unusual polyamines produced by an extreme thermophile, Thermus thermophilus. Biochemical Journal. 2005. 388(2), 427-433
• N1-Aminopropylagmatine, a New Polyamine Produced as a Key Intermediate in Polyamine Biosynthesis of an Extreme Thermophile, Thermus thermophilus. Journal of Biological Chemistry. 2005. 280(34), 30073-30082

ｍore...

• Method for preparation of deoxyribonucleoside by nucleophilic ring-opening of anhydronucleoside
• Highly stereoselective method for deuterium-labeling

• 安定同位体の利用技術に関する研究動向調査 2章 有機化学・生化学研究での安定同位体利用
  新エネルギー・産業技術総合開発機構 1997
• Search and Investigation for the Technological Development of the Stable Isotope 2 Utility of the Stable Isotope in the field of organic Chemistry and Biology
  NEDO 1997
• Search and Investigation for the Technological Development of the Stable Isotope 2 Utility of the Stable Isotope in the field of organic Chemistry and Biology
  NEDO 1997
• An Improved Synthesis of 2,5,6-Trichlorobenzimidazole.
  Nucleic Acid Chemistry Wiley, New York 1991
• An Improved Synthesis of 2,5,6-Trichlorobenzimidazole.
  Nucleic Acid Chemistry Wiley, New York 1991

• 難治性疾患の予防・治療薬の創製の研究
  2000 -
• Development of a preventive or a therapeutic medicines for the intractable disease.
  2000 -

• - 1966 Tokyo University of Pharmacy and Life Sciences School of Pharmacy
• - 1966 Tokyo University of Pharmacy and Life Science Faculty of Pharmaceutical Science

• Ph.D (Tohoku University)

International Society of Heterocyclic Chemistry ,  日本糖質学会 ,  INTERNATIONAL SOCIETY OF NUCLEIC ACIDS CHEMISTRY ,  有機合成化学協会 ,  日本薬学会 ,  International Society of Heterocyclic Chemistry. ,  Japan. The Japanese Society of Carbohydrate Research. INTERNATIONAL SOCIETY OF NUCLEIC ACIDS CHEMISTRY. ,  The Pharmacutical Society. The Society of Synthetic Organic Chemistry