Research field (3)：
Biophysics
, Bio-, chemical, and soft-matter physics
, Molecular biochemistry
Research keywords (5)：
反応座標に対する機械学習
, 細胞ダイナミクスのモデリング
, multiscale modeling
, Conformational change of proteins
, Quantum dynamics of biomolecules
Research theme for competitive and other funds (12)：
2022 - 2025 Non-adiabatic transition dynamics in aggregation-induced emission
2022 - 2025 Machine learning of high-dimensional life dynamics time series for reduction to low-dimensional systems and its application to controlling problems
2019 - 2023 機械学習で議事録を分析:PBLチュートリアルチューター支援システムの開発
2019 - 2022 リアルタイムイメージングから構築するがん細胞動態の高精度予測モデル
2017 - 2021 Searching the bottleneck of enzymatic reactions: Reaction path sampling calculation accompanied with experiment
2016 - 2019 Novel characterization of rare events in dynamic data and its application to biological time series
2015 - 2018 Construction and Validation of Multi-scale Simulations based on the Parallel-in-Time Method
2014 - 2017 The gout medicine which has strong effects on mammalian XOR but not on bacterial XOR: dynamics of the interaction between enzyme XOR and its inhibitor BOF
2013 - 2016 Application of new methods of statistical analysis to functional movements of biomolecules
2011 - 2013 Establishment of Multiscale Analysis for Daily Nonlinear Phenomena and its Application
2011 - 2013 The study on the structure-based inhibitor mechanism for xanthine oxidoreductase: beyond a lock-key system
2010 - 2012 Theoretical approaches to vibrational quantum dynamics of biomolecules and its control
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Papers (65)：
Hiroshi Fujisaki, Hiromichi Suetani, Luca Maragliano, Ayori Mitsutake. Non-Markov-Type Analysis and Diffusion Map Analysis for Molecular Dynamics Trajectory of Chignolin at a High Temperature. Life. 2022
Kenta Odagiri, Hiroshi Fujisaki. Mathematical model for wound healing caused by exogeneous mechanical forces. INTERNATIONAL CONFERENCE OF COMPUTATIONAL METHODS IN SCIENCES AND ENGINEERING ICCMSE 2020. 2021
Hiroshi Fujisaki, Yasuhiro Matsunaga, Kei Moritsugu. Weighted ensemble simulations for conformational changes of proteins. INTERNATIONAL CONFERENCE OF COMPUTATIONAL METHODS IN SCIENCES AND ENGINEERING ICCMSE 2020. 2021
Kenta Odagiri, Hiroshi Fujisaki, Hiroya Takada, Rei Ogawa. Numerical simulation using cellular Potts model for wound closure with ATP release and the mechanobioligical effects. 2022
Fujisaki Hiroshi. Multiscale Aspects of Molecular Motions: From Molecular Vibrations, Conformational Changes of Biomolecules to Cellular Dynamics. Journal of Nippon Medical School. 2022. 89. 1. 9-15
松永康佑, 森次圭, 藤崎弘士. How Can We Describe the Conformational Change of Proteins?-Advances in Path Sampling Techniques for Biomolecules. 日本物理学会誌. 2021. 76. 11
藤崎弘士, 森次圭, 松永康佑, 山本典史, 末谷大道. Kinetics of conformational changes of proteins calculated by manifold learning. 日本物理学会講演概要集(CD-ROM). 2021. 76. 2
Proteins: Energy, Heat and Signal Flow (Computation in Chemistry)
Taylor and Francis/CRC Press, London 2009 ISBN:9781420087031
Normal Mode Analysis: Theory and Applications to Biological and Chemical Systems
Chapman and Hall/CRC Press, Boca Raton, Florida 2005 ISBN:9781584884729
Professional career (2)：
Ph.D (University of Tokyo)
Ms.D (University of Tokyo)
Work history (8)：
2019/04 - Nippon Medical School Faculty of Medicine Full Professor
