Rchr

J-GLOBAL ID：200901045615881866 Update date: Feb. 01, 2024

Nakayama Koji

ナカヤマコウジ | Nakayama Koji

Affiliation and department：
Job title： Professor

Research field (1)： Oral medicine

Research keywords (2)：口腔微生物学 , 微生物学

Research theme for competitive and other funds (55)：

2020 - 2023 Elucidation of feedback regulation of the expression of the type IX secretion system (T9SS) of Porphyromonas gingivalis
2016 - 2019 Complete analysis of the composition and biosynthesis mechanism of specific O-polysaccharides present in a periodontal pathogen's LPS
2016 - 2019 Formation model of Bacteroidia bacteria pilus-X-ray crystal structure analysis and molecular reconstruction experiment-
2016 - 2018 Elucidation of cascade regulation by two different control systems of the type IX secretion system
2014 - 2017 Development of new periodontal disease prevention method using ECF sigma factors of periodontal pathogenic bacteria

2012 - 2017 Structure and dynamics of gliding machinery in Bacteroidetes phylum bacteria

2012 - 2017 Generalization of harmonized supramolecular motility machinery and its diversity

2014 - 2016 Biogenesis of sugar moiety of anionic lipopolysaccharide associated with CTD proteins

2013 - 2016 Regulation of the gene expression of the type IX secretion component proteins in Porphyromonas gingivalis

2013 - 2016 Elucidation of the mechanism of systemic diseases by a periodontal pathogen in the intracellular transport

2013 - 2016 Supermolecule structure and mechanism of a novel bacterial protein secretion system, type IX secretion system

2012 - 2015 Relationship between periodontal infection and HIV infection in Kenya using simultaneous microsphere-based multiplex assays

2012 - 2014 Challenge to generate site-direct mutants of the periodontal pathogen Prevotella intermedia

2011 - 2014 Analysis of the pathway from periodontal disease to lipid metabolism perturbation

2010 - 2011 Dual regulation of secretion system of periodontal virulence factors by novel two-component system and ECF sigma factor

2009 - 2011 Analysis of regulatory mechanism of bone destruction and inflammation in experimental periodontitis mediated by IL-27 receptor

2009 - 2011 Investigation of the secretion system of pathogenic proteinases in Porphyromonas gingivalis and study of the way to control the system

2008 - 2010 Evaluation of the periodontal disease activity measuring the ability of dental plaque to activate innate immune system

2008 - 2010 Secretion mechanism of pathogenic proteases and adhesions in the periodontal pathogen Porphyromonas gingivalis.

2007 - 2008 Basic studies for drug discovery using adhesin domain protein and interdomain regional peptide of Porphyromonas gingivalis

2007 - 2008 Elucidation of the mechanism of skeletal development using Runx2 and Cbfb conditional knockout mice

2007 - 2008 Analysis of molecular mechanism of bone metabolism disruption by bacterial infection

2007 - 2008 Hydrogen Sulfide Production from Cysteine and Homocysteine by Periodontal and Oral Bacteria

2006 - 2007 ゲノム情報に基づいたP.gingivalisの宿主内での病原性因子調節機構の解析

2006 - 2007 Study for gignipain-related adhesins of Periodontal pathogen, Porphyromonas gingivalis for its platelet aggregation activity

2005 - 2007 Molecular Mechanisms of Interaction between Periodontitis and Cardiovascular and Bone Metabolic Disorders

2004 - 2007 Analysis of the mechanism for a periodontopathic bacteria P. gingivalis to escape from innate immune system

2004 - 2007 Integrate research of genomics and proteomics of novel molecular targets for development of periodontal diseases cure

2005 - 2006 抗生物質耐性遺伝子をもたない歯周病原細菌生菌ワクチンの開発

2005 - 2006 Study of membrane transport system in proteinase produced from Porphyromonas gingivalis

2004 - 2006 Role of coaggregation among periodontopathic bacteria in formation of periodontopathic biofilm

2005 - 2005 P.gingivalisの生体内環境における病原性発現調節機構の解析

2004 - 2005 口腔慢性細菌感染の心血管系および骨代謝系への影響とその病原因子に関する研究

2004 - 2005 Study on the oxidative stress responses of a major periodontopathogenic bacteria

2003 - 2004 Regulation of pathologic root resorption by control of MAPK signaling

2003 - 2004 Establishment of protein expression system in Porphyromonasi gingivalis

2003 - 2004 原核生物HSP90分子シャペロンの機能は真核生物と同じか?

2002 - 2004 Pest-sequencing analysis of periodontal pathogen Porphyromonas gingivalis : expression of its proteins by oral environmental fectors.

2003 - 2003 歯周病原細菌菌体表面タンパクの心血管系および骨代謝系に及ぼす影響

2002 - 2003 生菌ワクチン開発に向けた抗生物質耐性遺伝子をもたない歯周病原細菌変異株作製の試み

2002 - 2003 FUNCTIONAL ANALYSIS OF HEAT SHOCK PROTEIN HtpG FROM PF gingivalis WHICH CAUSES PERIODONTITIS

2001 - 2003 Investigation of New Drugs that Inhibit Acquisition of Iron from Oral Environments in the Periodontopathogen Porphyromonas gingivalis.

2002 - 2002 歯周病細菌のポストゲノム研究の新展開に向けて

2002 - 2002 原核生物および真核生物HSP90分子シャペロン共通の作用メカニズム

2002 - 2002 歯周病原細菌菌体表面タンパクの心血管系および骨代謝系に及ぼす影響

2001 - 2002 Effect of mixed infection by periodontopathic bacteria-increase of abscess formation on mice and responses by hosts.

2001 - 2001 歯周病原細菌ポルフィロモナス・ジンジバリスの血小板凝集因子の同定とその作用機構

1999 - 2000 歯周病原細菌由来へもグロビン結合タンパク質による血管素への傷害作用

1999 - 2000 Participation mechanism of periodontopathogenic bacteria into biofilm composed from subgingival bacteria flora with early colonizer

1999 - 2000 Effect of mixed infection on abscess formation and a role of gingipains in the pathogenecity

1998 - 2000 Molecular mechanism of acquisition and storage of iron from oral environment by the periodontopathogen Porphyromonas gingivalis.

1996 - 1997 ポルフィロモナスジンジバリスの黒色色素産生性と歯周病原性に関する分子遺伝学的研究

1995 - 1996 GENETIC AND BIOCHEMICAL STUDY ABOUT FUNCTION AND SECRETION MECHANISM OF EXTRACELLULAR PROTEINASES OF PERIODONTOPATHOGENIC MICROORGANISMS

1991 - 1993 Development of molecular genetics in oral bacteroides

1988 - Molecular genetical approach to study the periodontopathogenesis of Porphyromonas gingivalis

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Papers (223)：

中山真彰, 内藤真理子, 中山浩次, 大原直也. Porphyromonas gingivalisジンジパインによるphospholipase Cの活性化と歯周組織の炎症との関連性. Journal of Oral Biosciences Supplement. 2023. 2023. [P3-32]
中山真彰, 山口智之, 内藤真理子, 中山浩次, 大原直也. Porphyromonas gingivalisジンジパインによるPLCを介したCOX-2発現とPGE2産生の分子機序. 日本細菌学雑誌. 2023. 78. 1. 88-88
Satoshi Shibata, Yuhei O. Tahara, Eisaku Katayama, Akihiro Kawamoto, Takayuki Kato, Yongtao Zhu, Daisuke Nakane, Keiichi Namba, Makoto Miyata, Mark J. McBride, et al. Filamentous structures in the cell envelope are associated with bacteroidetes gliding machinery. Communications Biology. 2023. 6. 1
中山真彰, 内藤真理子, 中山浩次, 大原直也. Porphyromonas gingivalisジンジパインによるCOX-2発現とPGE2産生におけるホスホリパーゼの役割(The role of phospholipase on Porphyromonas gingivalis gingipains-induced COX-2 expression and PGE2 production). Journal of Oral Biosciences Supplement. 2022. 2022. 219-219
Mariko Naito, Mikio Shoji, Keiko Sato, Koji Nakayama. Insertional Inactivation and Gene Complementation of Prevotella intermedia Type IX Secretion System Reveals Its Indispensable Roles in Black Pigmentation, Hemagglutination, Protease Activity of Interpain A, and Biofilm Formation. Journal of Bacteriology. 2022

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MISC (138)：

中山真彰, 内藤真理子, 中山浩次, 大原直也, 大原直也. Porphyromonas gingivalisジンジパインによるphospholipase Cの活性化と歯周組織の炎症との関連性. Journal of Oral Biosciences Supplement (Web). 2023. 2023
中山真彰, 山口智之, 内藤真理子, 中山浩次, 大原直也, 大原直也. Porphyromonas gingivalis gingipains induce COX-2 expression and PGE2 production via phospholipase C. 日本細菌学雑誌(Web). 2023. 78. 1
中山真彰, 内藤真理子, 中山浩次, 大原直也, 大原直也. Role of calcium channels in COX-2 expression and PGE2 production by gingipains. 日本細菌学雑誌(Web). 2022. 77. 1
中山真彰, 内藤真理子, 中山浩次, 大原直也, 大原直也. The role of phospholipase on Porphyromonas gingivalis gingipains-induced COX-2 expression and PGE2 production. Journal of Oral Biosciences Supplement (Web). 2022. 2022
中山真彰, 内藤真理子, 中山浩次, 大原直也, 大原直也. The significance of calcium influx on COX-2 expression induced by P. gingivalis gingipains. 日本細菌学雑誌(Web). 2021. 76. 1

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Books (18)：

Hydrogen Sulfide: Sources, Detection and Health Hazards; Oral disease and hydrogen sulfide production by oral bacteria
NOVA Publishers 2012
Hydrogen Sulfide: Sources, Detection and Health Hazards; Oral disease and hydrogen sulfide production by oral bacteria
NOVA Publishers 2012
Periodontal Medicine and Systems Biology, chapter 13: Genomics of Porphyromonas gingivalis
Wiley-Blackwell 2009
Periodontal Medicine and Systems Biology, chapter 13: Genomics of Porphyromonas gingivalis
Wiley-Blackwell 2009
口腔微生物学免疫学
医歯薬出版 2005

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Lectures and oral presentations (19)：

A cargo protein, PorA, of the type IX secretion system (T9SS) acts as a T9SS regulator upstream of the two-component system PorXY and the ECF sigma factor SigP.
(The 61st Annual Meeting of Japanese Association for Oral Biology 2019)
9型分泌機構の基質タンパク質であるPorAは二成分制御系PorXYとECFシグマ因子SigPの上流で正の制御因子として機能する
(第72回日本細菌学会九州支部総会・第56回日本ウイルス学会九州支部総会 2019)
バクテロイデーテス門細菌のIX型分泌機構およびV型線毛の研究(受賞講演)
(第90回日本細菌学会 2017)
The type IX secretion, gliding motility and the type V pilus
(Protein Secretion in Bacteria Conference 2016)
Type IX secretion system and gliding motility in Bacteroidetes phylum bacteria
(13th Japan-Korea Microbiology Symposium 2016)

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Education (4)：

1977 - 1981 Kyushu University
- 1981 Kyushu University Graduate School, Division of Dental Research
1971 - 1977 Kyushu University School of Dentistry
- 1977 Kyushu University Faculty of Dentistry

Professional career (1)：

D.D.S (Kyushu University)

Work history (26)：

2018 - 現在 Nagasaki University
2018/04 - 2023/03 Nagasaki University Graduate School of Biomedical Sciences
2002 - 2018 Nagasaki University Graduate School of Biomedical Sciences
2013 - 2015 Nagasaki University
2008 - 2013 Nagasaki University

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Committee career (14)：

2023/12 - 現在日本細菌学会名誉会員
2023/06 - 現在公益財団法人発酵研究所評議員
2020/10 - 現在歯科基礎医学会名誉会員
2000/01 - 2020/12 日本細菌学会評議員
2012 - 2014 日本細菌学会理事

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Awards (3)：

2017/03 - Japanese Society for Bacteriology Asakawa Award
2008/07 - International Association for Dental Research Basic Research in Periodontal Disease Award
2001/04 - 日本細菌学会「小林六造記念賞」

Association Membership(s) (17)：

国際歯科研究学会日本部会 , 国際歯科研究学会 , 歯科基礎医学会 , 日本細菌学会 , American Society for Biochemistry and Molecular Biology , Japanese Association for Dental Research , The International BioIron Society , Society for Genome Microbiology in Japan , The Japanese BioIron Society , Japanese Society for Bone and Mineral Reseach , International Association for Dental Research , Japanese Society of Periodontology , American Society for Microbiology , Japanese Association for Oral Biology , Japanese Society for Molecular Biology , The Genetics Society of Japan , Japanese Society for Bacteriology

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