Kitagawa Motoo

キタガワモトオ | Kitagawa Motoo

Affiliation and department：
Job title： Chiba University
Homepage URL (1)： https://narita.iuhw.ac.jp/staff/igakubu/3095.html

Research field (1)： Medical biochemistry

Research keywords (2)： Signal transduction , Notch signaling

Research theme for competitive and other funds (17)：

2019 - 2022 Notch受容体の細胞表面における活性化調節機構
2016 - 2020 Functions of regulators for Notch signaling, almondex/TM2D3
2012 - 2017 Elucidation of interactive mechanism on wound healing process after low temperature plasma treatment
2012 - 2014 Involvement of a co-factor of Notch signaling, Mastermind, into Schizophrenia
2010 - 2012 Fragmented hyaluronan is an autocrine factor potentiating cancer cell invasion supported by HAS2 -CD44/hyaluronidase-2 system on the plasma membrane

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Papers (62)：

Wataru Masuda, Tomoko Yamakawa, Rieko Ajima, Katsuya Miyake, Toshifumi Umemiya, Kazuhiko Azuma, Jun-ichi Tamaru, Makoto Kiso, Puspa Das, Yumiko Saga, Kenji Matsuno, Motoo Kitagawa. TM2D3, a mammalian homologue of Drosophila neurogenic gene product Almondex, regulates surface presentation of Notch receptors. Scientific Reports. 2023. 13. 20913
Ken-Ichi Hirano, Akiko Suganami, Yutaka Tamura, Hideo Yagita, Sonoko Habu, Motoo Kitagawa, Takehito Sato, Katsuto Hozumi. Delta-like 1 and Delta-like 4 differently require their extracellular domains for triggering Notch signaling in mice. eLife. 2020. 9. e50979
Puspa Das, Jose L. Salazar, David Li-Kroeger, Shinya Yamamoto, Mitsutoshi Nakamura, Takeshi Sasamura, Mikiko Inaki, Wataru Masuda, Motoo Kitagawa, Tomoko Yamakawa, et al. Maternal <i>almondex</i>, a neurogenic gene, is required for proper subcellular Notch distribution in early <i>Drosophila</i> embryogenesis. Development, Growth & Differentiation. 2019. 62. 1. 80-93
北川元生, 増田渉, 山川智子, 安島理恵子, 梅宮敏文, 東和彦, 田丸淳一, 相賀裕美子, 松野健治. TM2 domain containing 3(TM2D3)によるNotch1の活性化. 国際医療福祉大学学会誌. 2018. 23. 抄録号. 151-151
M. Toritsuka, S. Kimoto, K. Muraki, M. Kitagawa, T. Kishimoto, A. Sawa, K. Tanigaki. Regulation of striatal dopamine responsiveness by Notch/RBP-J signaling. TRANSLATIONAL PSYCHIATRY. 2017. 7. e1049

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MISC (30)：

北川元生, 増田渉, 増田渉, 山川智子, 安島理恵子, 三宅克也, 板橋匠美, 梅宮敏文, 梅宮敏文, 東和彦, et al. Transmembrane2domain containing3(TM2D3)はNotch受容体の細胞表面の発現を制御する. 日本分子生物学会年会プログラム・要旨集(Web). 2020. 43rd
北川元生, 増田渉, 山川智子, 安島理恵子, 三宅克也, 梅宮敏文, 東和彦, 田丸淳一, 相賀裕美子, 松野健治. TM2 domain containing 3(TM2D3)はNotch受容体の細胞表面の発現を制御する. 国際医療福祉大学学会誌. 2019. 24. 抄録号. 171-171
Asuka Kawano, Satoshi Ota, Takashi Oide, Jun Matsushima, Masaki Suzuki, Masami Iwamoto, Takashi Kishimoto, Motoo Kitagawa, Nobuyuki Araki, Sonoko Misawa, et al. POEMS Syndrome: A Study of Five Autopsy Cases With Emphasis on the Significance of Subcutaneous Calciphylaxis. LABORATORY INVESTIGATION. 2015. 95. 6A-6A
北川元生. Notchシグナルの分子機構の研究 Mastermindを中心として. 千葉医学雑誌. 2011. 87. 6. 259-266
Kenichi Harigaya, Teruyoshi Saito, Kazuhiko Azuma, Toshifumi Umemiya, Akihiro Toyoda, Yuki Shida, Motoo Kitagawa. CD44 has dual functions to enhance the hyaluronan-induced chemokinesis in cancer cells as an associated molecule of hyaluronidase2-mediated HA catabolism and a hyaluronan receptor for RhoGTPase activation. CANCER RESEARCH. 2011. 71

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Lectures and oral presentations (5)：

POEMS Syndrome: A Study of Five Autopsy Cases With Emphasis on the Significance of Subcutaneous Calciphylaxis
(LABORATORY INVESTIGATION 2015)
CD44 has dual functions to enhance the hyaluronan-induced chemokinesis in cancer cells as an associated molecule of hyaluronidase2-mediated HA catabolism and a hyaluronan receptor for RhoGTPase activation
(CANCER RESEARCH 2011)
Fragmented hyaluronan is an autocrine chemokinetic motility factor supported by HAS2-CD44/hyaluronidase-2 system on the plasma membrane
(INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 2010)
Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2.
(J. Interferon Res. 1993)
IRF-1 and IRF-2 ; A link between interferon system and the regulation of cell growth.
(J.Interferon Res. 1992)

Works (7)：

The role of TM2D proteins in the Notch signaling pathway and amyloid cascade
2013 - 現在
The role of Mastermind proteins in the Notch signaling pathway
1999 - 現在
Notchシグナル伝達系におけるMastermindタンパク質の役割
1999 - 現在
Molecular mechanisms of tumorigenesis and tumor suppression
Intracellular signal transduction

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Education (2)：

Professional career (2)：

Work history (11)：

2017/04 - 現在 International University of Health and Welfare School of Medicine Professor
2023/10 - 2024/03 Kyushu University Institute for Materials Chemistry and Engineering
2007/04 - 2017/03 Chiba University Graduate School of Medicine Associate Professor
2001/04 - 2007/03 Chiba University Graduate School of Medicine Associate Professor
1998/04 - 2001/03 Chiba University School of Medicine Associate Professor

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Awards (1)：

Association Membership(s) (5)：

THE JAPANESE BIOCHEMICAL SOCIETY , American Society for Biochemistry and Molecular Biology , 日本癌学会 , American Society for Microbiology , 日本分子生物学会

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