Yoshizumi Tomoharu | Researcher Information

2025 - 2028 Innovative Elucidation of the Cancer Immune Microenvironment Promoting Hepatocellular Carcinoma Recurrence under Immunosuppressive Conditions after Liver Transplantation
2025 - 2028 癌部・非癌部におけるフェロトーシス制御による脂肪性肝炎の革新的治療戦略の確立
2024 - 2028 The Novel approach for Liver Cirrhosis developed by human liver cirrhosis model using iPS technology
2023 - 2028 切除不能な肝門部領域胆管癌に対する生体肝移植で治癒に至る分子生物学的特性の解明
2024 - 2027 Overcoming acute exacerbation of interstitial lung diseases and progression of lung cancer by M2 macrophage inhibition

2024 - 2027 血管新生阻害剤の臨床効果を予測する革新的コンパニオン診断薬の開発

2024 - 2027 マルチオミクス免疫微小環境解析による非ウイルス性肝癌の発癌機序と治療応答性の解明

2024 - 2027 老化に伴う形質的変化に着目した生体肝移植成績の革新的向上戦略

2023 - 2026 生体肝移植後長期予後を目指した革新的なグラフト質的評価法の樹立

2023 - 2026 Elucidation of the mechanism of metastasis and acquisition of malignancy in postoperative recurrence of hepatocellular carcinoma and construction of an innovative treatment strategy

2023 - 2026 Change of tumor microenvironment in hepatocellular carcinoma following systemic therapy

2023 - 2026 Development of medical equipment for minimally invasive diagnosis of steatohepatitis or carcinogenesis

2023 - 2026 免疫微小環境を標的とした高悪性度肝細胞癌に対する統合的治療戦略の開発

2022 - 2025 時・空間的シングルセル解析による膵がん細胞の悪性度獲得機構の解明と治療標的の同定

2022 - 2025 癌微小環境とサルコペニアの連関をターゲットとした革新的な膵癌治療法の探索

2022 - 2025 Cas9発現iPS細胞を用いた機能特化型肝再生による、革新的肝不全治療の開発

2021 - 2024 Genomics analysis of immune microenvironmental changes in hepatocarcinogenesis after cure of hepatitis C

2021 - 2024 Development of the innovative treatment using self iPS cell for acute liver failure

2021 - 2024 Highly Sensitive Detection for HBV Driver Mutations and Construction of a PRS Model

2021 - 2024 Development of the novel therapy for NAFLD by Engineering Fatty Liver from iPS cells

2022 - 2024 New treatment methods for liver failure by human iPS cells

2022 - 2023 生体肝移植における革新的グラフト機能評価方法の探索

2019 - 2022 The role of ferroptosis in hepatocellular carcinoma

2019 - 2022 The analysis of epigenetic aging in patients who undergo hepatectomy and in liver transplant recipients

2022 - 2022 iSP細胞を用いた肝不全に対する革新的治療法の確立

2018 - 2021 Epigenome and transcriptome analysis of hepatocellular carcinoma after eradication of hepatitis C virus

2018 - 2021 New strategy of hepatocellular carcinoma treatment using exosomes exocrimned by cancer associated fibroblast

2018 - 2021 Elucidation of the molecular mechanism of hepatic encephalopathy and development of innovative treatment by intestinal bacterial flora profiling

2018 - 2021 Autophagy and mitophagy in advanced hepatocellular carcinoma

2018 - 2021 Development of renal protection-oriented immunosuppressive therapy after organ transplantation utilizing mTOR inhibitor

2016 - 2021 Analysis of host and viral factors involved in flavivirus symbiosis and evolution

2018 - 2020 肝移植後肝細胞癌再発に対する機序解明と革新的治療戦略の構築

2017 - 2020 Development of new treatment methods for primary biliary cholangitis by genome and lipid information from disease mimic culture system

2015 - 2020 Development of Innovative Treatment Targeting the Sphere Formation Mechanism Involving Cancer Stem Cells

2018 - 2020 Prevention of HBV recurrence by HBV vaccination based on SNP and allele of HLA class II

2016 - 2019 Development of new therapy for enhancing liver regeneration by WFA-M2BP, which is a new biomarker for liver fibrosis.

2016 - 2019 肝細胞の代謝制御におけるオートファジーの意義-KO細胞の網羅的メタボローム解析

2016 - 2019 The roles of Nrf2 on progression in hepatocellular carcinoma

2016 - 2019 Analyses of regulatory B cell functions for tailor-made immunosuppression after liver transplantation

2019 - 2019 生体肝移植における腸内細菌叢の解析

2015 - 2018 The roles of autophagy in liver regenetion in a steatotic liver

2015 - 2018 Psychosocial assessment of living liver donors and recipients: a retrospective and prospective study

2015 - 2018 The biological analysis of sugar chain signal between hepatic stelate cells and macrophages in the progression of liver fibrosis.

2014 - 2017 Ischemia-Reperfusion Injury in Fatty Liver Is Mediated by Activated NADPH Oxidase 2 in Rats

2013 - 2016 The role of macrophage of spleen in wound healing and cancer progression

2013 - 2016 Molecular mechanism of autophagy during differentiation and induction of hepatic stem cells in liver injury and regeneration

2015 - 2016 安全・確実な生体肝移植の施行を目指した肝移植手術手技の定型化による移植医育成プログラムの策定と妥当性の検証

2014 - 2016 Mechanism of sarcopnia in outer space

2012 - 2015 The significance of tumor associated macrophage in recurrent hepatocellular carcinoma after liver transplantation

2012 - 2015 Microenvironment in hepatocellular carcinoma

2015 - 2015 生体肝移植術の成績向上を目指した総合的治療戦略

2011 - 2014 Treatment strategies of recurrent hepatitis C after liver transplantation based on IL28B singlencleotide polymorphism.

2011 - 2013 Impact of autophagy in liver regeneration

2011 - 2011 レシピエント由来血管内皮幹細胞誘導による生体肝移植後過小グラフト克服

2011 - 2011 肝再生過程におけるオートファジーの分子機序解明に関する研究

2008 - 2010 Development of novel gene-therapy using IL-12 and DNA nanoassociate bearing hyaluronan-glycocalyx for recurrent hepatocellular carcinoma after liver transplantation

2007 - 2008 細胞の冬眠タンパク誘導を利用した新たな肝保存装置の開発

2007 - 2008 Prevention of hepatocellular carcinoma recurrence after livertransplantation by managing regulatory T cells

2007 - 2008 免疫抑制と脾臓摘出のリンパ球分画への影響

2005 - 2006 Combined interleukin-12 and Dendritic cell neoadjuvant immunotherapy for hepatocellular carcinoma in immunosuppressed mice

2004 - 2005 肝移植におけるSplit-Toleranceの機序の解明に関する研究

肝移植における過小グラフト症候群の機序解明

Small-for-size graft in Living donor Liver Transplantation

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Kyoto Matsudo, Kazuki Takada, Asato Hashinokuchi, Taichi Nagano, Fumihiko Kinoshita, Takaki Akamine, Mikihiro Kohno, Tomoyoshi Takenaka, Mototsugu Shimokawa, Yoshinao Oda, et al. Significance of Tumor Microvasculature in the Tumor Microenvironment in Adenocarcinoma with EGFR Common Mutations. Annals of surgical oncology. 2025. 32. 4. 3031-3039
Kyoto Matsudo, Kazuki Takada, Asato Hashinokuchi, Taichi Nagano, Fumihiko Kinoshita, Takaki Akamine, Mikihiro Kohno, Tomoyoshi Takenaka, Mototsugu Shimokawa, Yoshinao Oda, et al. ASO Visual Abstract: Significance of Tumor Microvasculature in the Tumor Microenvironment in Adenocarcinoma with EGFR Common Mutation. Annals of surgical oncology. 2025
Asato Hashinokuchi, Fumihiko Kinoshita, Makoto Iimori, Keisuke Kosai, Yuya Ono, Takumi Tomonaga, Bassi Giacomo, Kyoto Matsudo, Taichi Nagano, Takaki Akamine, et al. DNA Polymerase Delta 2 Activates Cell Cycle in Lung Adenocarcinoma, Leading to High Malignancy and Poor Prognosis. Annals of surgical oncology. 2025
Katsuya Toshida, Shinji Itoh, Norifumi Iseda, Shugo Tanaka, Kensuke Nakazono, Takahiro Tomiyama, Shohei Yoshiya, Takeo Toshima, Noboru Harada, Kenichi Kohashi, et al. The Impact of TP53-Induced Glycolysis and Apoptosis Regulator on Prognosis in Hepatocellular Carcinoma: Association with Tumor Microenvironment and Ferroptosis. Liver cancer. 2025. 14. 1. 36-57
Yasushi Tanaka, Qingjiang Hu, Tetsuro Kawazoe, Hirotada Tajiri, Ryota Nakanishi, Yoko Zaitsu, Yuichiro Nakashima, Mitsuhiko Ota, Eiji Oki, Yoshinao Oda, et al. The clinical significance of signal regulatory protein alpha expression in the immune environment of gastric cancer. International journal of clinical oncology. 2025. 30. 2. 330-339

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Shinji Itoh, Takeo Toshima, Tomoharu Yoshizumi. Recurrence of hepatocellular carcinoma following liver transplantation. Journal of Japanese Society of Gastroenterology. 2024. 121. 9. 729-736
Shinji Itoh, Tomoharu Yoshizumi. Robot-assisted liver resection. Kanzo/Acta Hepatologica Japonica. 2023. 64. 12. 595-602
渡部健二, 松堂響人, 橋之口朝仁, 長野太智, 木下郁彦, 高森信吉, 河野幹寛, 三浦奈央子, 竹中朋祐, 吉住朋晴. 肺腺癌における腫瘍関連好中球とInterleukin-38との関連の検討. 日本外科学会定期学術集会(Web). 2023. 123rd
竹中朋祐, 橋之口朝仁, 松堂響人, 長野太智, 渡部健二, 高森信吉, 河野幹寛, 三浦奈央子, 吉住朋晴. 転移性肺腫瘍の外科治療-原発巣別の治療成績と化学療法の与える影響-. 日本外科学会定期学術集会(Web). 2023. 123rd
三浦奈央子, 橋之口朝仁, 松堂響人, 渡部健二, 長野太智, 高森信吉, 河野幹寛, 竹中朋祐, 吉住朋晴. 外科医のキャリア形成について~「女性外科医」に関する議論がなくなる日を目指して~. 日本外科学会定期学術集会(Web). 2023. 123rd

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生体肝移植グラフト質的評価マーカーとしてのLRRN2 の有用性に関する検討
(第77回日本消化器外科外科学会 2022)
当科でのT4b大腸癌に対する腹腔鏡手術の治療成績
(第35回日本内視鏡外科学会総会 2022)
Cureをめざした大腸癌肝転移に対する二期的肝切除によるConversion surgery
(第31回日本癌病態治療研究会 2022)
ロボット支援下胸腔鏡下食道切除術の短期成績
(第35回日本内視鏡外科学会総会 2022)
上腸間膜静脈閉塞13年後に十二指腸静脈瘤をきたし浅大腿静脈グラフトによる再建が有効であった1例
(第120回消化器病学会九州支部例会 2022)

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医学博士

2016/04 - 2018/03 九州大学教務委員

2023/03 - 上原記念生命科学財団研究助成金
2022/01 - テルモ生命科学振興財団研究助成金
2020/12 - 日本移植学会Novartis Pharma Grants for Basic Research 2020
2019/10 - 日本消化器外科学会インド消化器外科学会派遣
2016/05 - 肝臓学会 High Citation Award

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Japan Biliary Association , 日本呼吸器外科学会 , 日本消化器癌発生学会 , 日本胸部外科学会 , The Japan Society of Hepatology , Japanese Society of Gastroenterology , Japanese Society of Gastroenterological Surgery , Japan Society of Clinical Oncology , Japan Surgical Association , 日本癌学会 , 日本乳がん学会 , 日本肺癌学会 , 日本胆道学会 , 日本心臓外科学会 , The japan Society for Transplantation , The Transplantation Society , International Liver Transplant Society , Japanese Society of Hepato-biliary-pancreatic surgery , Japan Surgical Society , 日本肝癌研究会 , 日本肝移植学会 , American society of transplant surgeons