Iwase Hirotaka

イワセヒロタカ | Iwase Hirotaka

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www2.kuh.kumamoto-u.ac.jp/breast/index.html

Research field (1)： General surgery, pediatric surgery

Research keywords (6)：バイオロジー , 全身療法 , 乳癌の手術治療 , biology analysis in breast cancer , systemic treatment , Surgecal management

Research theme for competitive and other funds (4)：

2012 - エストロゲン療法による乳癌内分泌療法抵抗性の克服
2012 - Overcoming endocrine therapy resistance with estrogen treatment in breast cancer
2007 - BRCA1機能喪失乳癌と基底膜細胞型乳癌
2007 - BRCA1 deficient breast cancer and basallike-tumor

Papers (53)：

Pegram MD, Bondarenko I, Zorzetto MMC, Hingmire S, Iwase H, Krivorotko PV, Lee KS, Li RK, Pikiel J, Aggarwal R, et al. PF-05280014 (a trastuzumab biosimilar) plus paclitaxel compared with reference trastuzumab plus paclitaxel for HER2-positive metastatic breast cancer: a randomised, double-blind study. British journal of cancer. 2019. 120. 2. 172-182
Takeshita T, Iwase H. dPCR Mutational Analyses in Cell-Free DNA: A Comparison with Tissues. Methods in molecular biology (Clifton, N.J.). 2019. 1909. 105-118
Hirotaka Inoue, Naoki Shinojima, Ryuta Ueda, Keizo Yamamoto, Norio Ishii, Motoyuki Igata, Junji Kawashima, Eiichi Araki, Hirotaka Iwase, Yoshiki Mikami, et al. A Rare Case of Thyrotropin-Secreting Pituitary Adenoma Coexisting with Papillary Thyroid Carcinoma Presenting with Visual Disturbance without Hyperthyroidism. World neurosurgery. 2018. 119. 394-399
Goto-Yamaguchi L, Yamamoto-Ibusuki M, Yamamoto Y, Fujiki Y, Tomiguchi M, Sueta A, Takeshita T, Iwase H. Therapeutic predictors of neoadjuvant endocrine therapy response in estrogen receptor-positive breast cancer with reference to optimal gene expression profiling. Breast cancer research and treatment. 2018. 172. 2. 353-362
Fujiki Y, Yamamoto Y, Sueta A, Yamamoto-Ibusuki M, Goto-Yamaguchi L, Tomiguchi M, Takeshita T, Iwase H. APOBEC3B gene expression as a novel predictive factor for pathological complete response to neoadjuvant chemotherapy in breast cancer. Oncotarget. 2018. 9. 55. 30513-30526

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MISC (281)：

Aiko Sueta, Yutaka Yamamoto, Mitsuhiro Hayashi, Satoko Yamamoto, Toko Inao, Mutsuko Ibusuki, Keiichi Murakami, Hirotaka Iwase. Clinical significance of pretherapeutic Ki67 as a predictive parameter for response to neoadjuvant chemotherapy in breast cancer; is it equally useful across tumor subtypes?. SURGERY. 2014. 155. 5. 927-935
Aiko Sueta, Yutaka Yamamoto, Mitsuhiro Hayashi, Satoko Yamamoto, Toko Inao, Mutsuko Ibusuki, Keiichi Murakami, Hirotaka Iwase. Clinical significance of pretherapeutic Ki67 as a predictive parameter for response to neoadjuvant chemotherapy in breast cancer; is it equally useful across tumor subtypes?. SURGERY. 2014. 155. 5. 927-935
Bo Huang, Yoko Omoto, Hirotaka Iwase, Hiroko Yamashita, Tatsuya Toyama, Raoul Charles Coombes, Aleksandra Filipovic, Margaret Warner, Jan-Ake Gustafsson. Differential expression of estrogen receptor alpha, beta 1, and beta 2 in lobular and ductal breast cancer. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014. 111. 5. 1933-1938
Mitsuhiro Hayashi, Hirofumi Jono, Satoru Shinriki, Takuya Nakamura, Jianying Guo, Aiko Sueta, Mai Tomiguchi, Saori Fujiwara, Mutsuko Yamamoto-Ibusuki, Kei-ichi Murakami, et al. Clinical significance of CYLD downregulation in breast cancer. BREAST CANCER RESEARCH AND TREATMENT. 2014. 143. 3. 447-457
Bo Huang, Yoko Omoto, Hirotaka Iwase, Hiroko Yamashita, Tatsuya Toyama, Raoul Charles Coombes, Aleksandra Filipovic, Margaret Warner, Jan-Ake Gustafsson. Differential expression of estrogen receptor alpha, beta 1, and beta 2 in lobular and ductal breast cancer. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014. 111. 5. 1933-1938

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Books (12)：

Estrogen receptor structure and function in breast cancer pathogenesis.(共著)
Reproductive Oncology 2007
乳管内乳頭腫
外科治療(増刊) 2007
乳癌
メディカルレビュー 2007
再発乳がんに対する内分泌療法
臨床外科 2007
ホルモン依存性癌乳癌
別冊日本臨床新領域別症候群シリーズ内分泌症候群(第2版)? 2006

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Lectures and oral presentations (24)：

乳癌内分泌療法に伴う骨病変とその治療
(第11回癌と骨病変研究会 2008)
トリプルネガティブ乳癌の生物学的特
(第三期第2回乳がんTV講座 2008)
乳腺・内分泌外科領域の最新治療
(熊本県医師会医学講座 2008)
乳がん検診のアレコレ ~早期発見が女性を乳がんから守ります~
(第13回日本産婦人科学会公開講座 2008)
Predictive factors for aromatase inhibitors in ER-positive, HER2-negative breast cancer
(AACR Special COnference in Cancer Research 2007)

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Works (12)：

乳癌における癌抑制遺伝子の機能解析
2003 - 2010
Functional analysis of novel tumor suppressor gene of breast cancer
2003 - 2010
転写モジュレーターによる乳癌内分泌療法の効果増強に関する研究
2007 - 2008
乳癌におけるエストロゲン合成・代謝酵素とホルモン環境
2004 - 2008
乳癌ホルモン療法効果予知診断キットの性能および有効性の評価
2006 - 2007

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Education (4)：

- 1986 Nagoya City University
- 1986 Nagoya City University Graduate School, Division of Medicine
- 1979 Nagoya City University
- 1979 Nagoya City University Faculty of Medicine

Professional career (1)：

Doctor of Medicine (Nagoya City University)

Work history (10)：

2010 - Kumamoto University Faculty of Life Sciences
2010 - Professor,Faculty of Life Sciences(Clinical medicine group),Kumamoto University
2004 - 2009 教授
2004 - 2009 Professor,
1999 - 2004 Nagoya City University

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Committee career (9)：

2005 - 日本臨床腫瘍学会評議員
2005 - 日本臨床外科学会評議員
2000 - 日本内分泌外科学会評議員
1999 - 日本癌治療学会臨床試験登録医
1998 - 日本臨床外科学会評議員

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Awards (2)：

2001 - アジア乳癌学会優秀賞
2001 - Award of 3rd Biannual Asia Breast Cancer Conference

Association Membership(s) (12)：

日本内分泌外科学会 , 日本臨床腫瘍学会 , 日本癌治療学会 , 日本乳癌学会 , 米国臨床腫瘍学会 , 日本臨床外科学会 , 日本内分泌学会 , 日本癌学会 , 日本甲状腺外科学会 , 米国癌学会 , American Sciety of Clinical Oncology , American Association of Cancer Research

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