Nakao Miki

ナカオミキ | Nakao Miki

Affiliation and department：
Job title： Professor
Homepage URL (2)： http://hyoka.ofc.kyushu-u.ac.jp/search/details/K001611/index.html , http://d.hatena.ne.jp/mikimnakao/

Research field (5)： Immunology , Marine/Aquatic life sciences , Aquaculture , Evolutionary biology , Molecular biology

Research keywords (6)：分子生物学 , 水産学 , 生物資源科学 , 免疫学 , Biological Resource Science , Immunology

Research theme for competitive and other funds (25)：

2022 - 2025 マイクロプラスチックの腸管神経系刺激とベクター効果による遊泳・摂餌・感染への影響
2022 - 2025 Molecular mechanism of bio-defense and homeostatic functions of the complement activation in fish cutaneous mucus
2019 - 2022 Regulation of T-cell activation and cellular immune response by intracellular activation of complement C3 in fish
2016 - 2019 Detection and identification of complement components in bony fish skin mucus and their interactome analysis
2016 - 2019 Enhancement of innate immune barrier of fish mucosa utilizing homeostatic functions of the complement system.

2013 - 2017 Molecular mechanism of activation and regulation of immune response by thrombocytes in fish

2006 - 2008 Elucidation of the activation network constructed by isotypic complement components diversified in the bony fish

2005 - 2006 幅広い魚種で機能する補体マスターキー分子の作出

2004 - 2005 Functional differentiation and molecular basis of complement component isotypes in bony fish.

2002 - 2003 Molecular cloning and functional analysis of carp complement regulatory factors : Molecular mechanism of C3 fragmentation.

2001 - 2003 Structure and function of the complement receptor type 2(CR2) in fish : regulation of the adaptive immunity by the complement system.

2000 - 2001 Functional analysis of the classical complement pathway in bony fish

1999 - 2000 PCB、DDTおよび有機スズ魚類の免疫系に与える影響

1999 - 2000 Molecular cloning and expression analysis of acute phase reactants in bony fish.

1998 - 2000 Development of a novel method for evaluating immunostimulants in fish based on gene expression.

1999 - 1999 海洋生物の自然免疫機構に関する共同研究

1998 - 1999 Functional analysis of the second and third complement component (C3) in carp using anti-peptide antibodies.

1997 - 1998 Divergent genes encoding the third complement component (C3) in carp.

1996 - 1997 Development of Rapid Rvaluation Methods for Immunopotentiators of Fish.

1996 - 1996 魚類におけるマンノース結合レクチンによる非特異的生体防御機構

1995 - 1995 魚類白血球上のアナフィラトキシンレセプターの同定

1994 - 1994 魚類免疫細胞上の補体第3成分(C3)レセプターの同定

魚類の免疫機構

Molecular characterization of the complement system in bony fish immune system

Immune Systems of Fishes

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Papers (108)：

Trang Thu Tran, Harsha Prakash, Takahiro Nagasawa, Miki Nakao, Tomonori Somamoto. Characterization of CD83 homologs differently expressed during monocytes differentiation in ginbuna crucian carp, Carassius auratus langsdorfii. Developmental & Comparative Immunology. 2024. 159. 105212-105212
Tsukasa Ryu, Keigo Okamoto, Satoshi Ansai, Miki Nakao, Anu Kumar, Taisen Iguchi, Yukiko Ogino. Gene Duplication of Androgen Receptor As An Evolutionary Driving Force Underlying the Diversity of Sexual Characteristics in Teleost Fishes. Zoological Science. 2024. 41. 1
Masaki Sukeda, Harsha Prakash, Takahiro Nagasawa, Miki Nakao, Tomonori Somamoto. Non-specific cytotoxic cell receptor protein-1 (NCCRP-1) is involved in anti-parasite innate CD8+ T cell-mediated cytotoxicity in ginbuna crucian carp. Fish & Shellfish Immunology. 2023. 139. 108904-108904
Rosli Nehlah, Akira Yamamoto, Takahiro Nagasawa, Tomonori Somamoto, Miki Nakao. Functional Analysis of Two Divergent C4 Isotypes in the Classical and Lectin Pathways of Complement Activation in the Common Carp (Cyprinus carpio). Journal of Marine Science and Engineering. 2023. 11. 4. 707-707
Harsha Prakash, Mitsuru Sato, Katsura Kojima, Atsushi Sato, Shinpei Maruyama, Takahiro Nagasawa, Miki Nakao, Tomonori Somamoto. Development of a filter device for the prevention of aquatic bacterial disease using a single-chain variable fragment (scFv)-conjugated affinity silk. Scientific reports. 2022. 12. 1. 9475-9475

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MISC (31)：

Miki Nakao. Role of the complement system in mucosal immunity and homeostasis of fish. 2024. 8. (7). 617-620
中尾実樹. 生物の進化と補体. 腎と透析. 2024. 97. 1. 16-20
Miki Nakao. Complement system in mucosal immunity of fish. Journal of the Japanese Association for Complement Research. 2022. 59. (2). 108-113
Miki Nakao. Multifaceted roles of the complement system: an evolutionary implication. 2022. 11. 1723-1727
NAKAO Miki. Evolution and phylogeny of the complement system and complementology. Kidney and Dialysis. 2017. 83. 4. 521-525

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Books (4)：

動物学の百科事典
丸善出版 2018 ISBN:9784621303092
The Evolution of the Immune System. Conservation and Diversification.
Elsevier 2016 ISBN:9780128019757
補体への招待
メジカルビュー 2011
Current Topics in Complement
Springer 2006 ISBN:0387322310

Lectures and oral presentations (6)：

Multifaceted roles of Tecrem, a CD46-like complement regulatory factor, in teleost
(2023)
Mucosal innate defense in carp fish involving T cells, complement system, and epithelial cells
(The 2nd Congress of Asian Society of Developmental and Comparative Immunology 2022)
Functional analysis of two complement C4 isotypes of carp using recombinant proteins
(The 1st Congress of Asian Society of Developmental and Comparative Immunology 2019)
Functional analysis of the classical activation pathway in teleost fish complement system: an evolutionary implication
(Asian Insect Immunity Symposium 2018)
Structural and functional diversity of the complement components in bony fish
(Japanese Association for Developmental and Comparative Immunology 2015)

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Education (4)：

- 1992 Kyushu University
- 1992 Kyushu University Graduate School, Division of Agriculture
- 1984 Kyushu University School of Agriculture
- 1984 Kyushu University Faculty of Agriculture

Professional career (2)：

(BLANK)
PhD (Kyushu University)

Work history (3)：

2002 - 2004 Kyushu University Faculty of Agriculture
2004 - Kyushu University Faculty of Agriculture
1992 - 2002 Kyushu University School of Agriculture

Committee career (12)：

2024/09 - 現在 Japanese Association for Developmental and Comparative Immunology Auditor
2018/11 - 現在 Asian Society of Developmental and Comparative Immunology Vice President
2017/03 - 現在 Frontiers in Immunology Specialty Chief Editor of Comparative Immunology section
2015/08 - 現在日本補体学会理事
2020/09 - 2024/08 Japanese Association for Developmental and Comparative Immunology President

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Awards (2)：

2021/09 - 日本補体学会日本補体学会優秀賞コイ体表粘液中の補体成分と補体活性化
2015/08 - Japanese Association for Developmental and Comparative Immunology The Furuta Award

Association Membership(s) (6)：

Internation Complement Society , JAPANESE ASSOCIATION FOR COMPLEMENT RESEARCH , International Society of Developmental and Comparative Immunology , 日本比較免疫学会 , 日本魚病学会 , 日本水産学会

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