2022 - 2025 Molecular mechanism of bio-defense and homeostatic functions of the complement activation in fish cutaneous mucus
2019 - 2022 Regulation of T-cell activation and cellular immune response by intracellular activation of complement C3 in fish
2016 - 2019 Detection and identification of complement components in bony fish skin mucus and their interactome analysis
2016 - 2019 Enhancement of innate immune barrier of fish mucosa utilizing homeostatic functions of the complement system.
2013 - 2017 Molecular mechanism of activation and regulation of immune response by thrombocytes in fish
2006 - 2008 Elucidation of the activation network constructed by isotypic complement components diversified in the bony fish
2005 - 2006 幅広い魚種で機能する補体マスターキー分子の作出
2004 - 2005 Functional differentiation and molecular basis of complement component isotypes in bony fish.
2002 - 2003 Molecular cloning and functional analysis of carp complement regulatory factors : Molecular mechanism of C3 fragmentation.
2001 - 2003 Structure and function of the complement receptor type 2(CR2) in fish : regulation of the adaptive immunity by the complement system.
2000 - 2001 Functional analysis of the classical complement pathway in bony fish
1999 - 2000 PCB、DDTおよび有機スズ魚類の免疫系に与える影響
1999 - 2000 Molecular cloning and expression analysis of acute phase reactants in bony fish.
1998 - 2000 Development of a novel method for evaluating immunostimulants in fish based on gene expression.
1999 - 1999 海洋生物の自然免疫機構に関する共同研究
1998 - 1999 Functional analysis of the second and third complement component (C3) in carp using anti-peptide antibodies.
1997 - 1998 Divergent genes encoding the third complement component (C3) in carp.
1996 - 1997 Development of Rapid Rvaluation Methods for Immunopotentiators of Fish.
1996 - 1996 魚類におけるマンノース結合レクチンによる非特異的生体防御機構
1995 - 1995 魚類白血球上のアナフィラトキシンレセプターの同定
1994 - 1994 魚類免疫細胞上の補体第3成分(C3)レセプターの同定
魚類の免疫機構
Molecular characterization of the complement system in bony fish immune system
Immune Systems of Fishes
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Papers (102)：
Masaki Sukeda, Harsha Prakash, Takahiro Nagasawa, Miki Nakao, Tomonori Somamoto. Non-specific cytotoxic cell receptor protein-1 (NCCRP-1) is involved in anti-parasite innate CD8+ T cell-mediated cytotoxicity in ginbuna crucian carp. Fish & Shellfish Immunology. 2023. 139. 108904-108904
Rosli Nehlah, Akira Yamamoto, Takahiro Nagasawa, Tomonori Somamoto, Miki Nakao. Functional Analysis of Two Divergent C4 Isotypes in the Classical and Lectin Pathways of Complement Activation in the Common Carp (Cyprinus carpio). Journal of Marine Science and Engineering. 2023. 11. 4. 707-707
Harsha Prakash, Mitsuru Sato, Katsura Kojima, Atsushi Sato, Shinpei Maruyama, Takahiro Nagasawa, Miki Nakao, Tomonori Somamoto. Development of a filter device for the prevention of aquatic bacterial disease using a single-chain variable fragment (scFv)-conjugated affinity silk. Scientific reports. 2022. 12. 1. 9475-9475
Koumei Shiota, Masaki Sukeda, Harsha Prakash, Masakazu Kondo, Teruyuki Nakanishi, Takahiro Nagasawa, Miki Nakao, Tomonori Somamoto. Local immune responses to two stages of Ichthyophthirius multifiliis in ginbuna crucian carp. Fish and Shellfish Immunology. 2021. 118. 19-24
Harsha Prakash, Shiori Motobe, Takahiro Nagasawa, Tomonori Somamoto, Miki Nakao. Homeostatic functions of tecrem, a cd46-like regulatory protein of complement activation, on epithelial cells in carp fish. Journal of Marine Science and Engineering. 2021. 9. 7
The Evolution of the Immune System. Conservation and Diversification.
Elsevier 2016 ISBN:9780128019757
補体への招待
メジカルビュー 2011
Current Topics in Complement
Springer 2006 ISBN:0387322310
Lectures and oral presentations (3)：
Functional analysis of the classical activation pathway in teleost fish complement system: an evolutionary implication
(Asian Insect Immunity Symposium 2018)
Structural and functional diversity of the complement components in bony fish
(Japanese Association for Developmental and Comparative Immunology 2015)
ゲノムデータからみた魚類補体制御因子の多様性
(アクアゲノム研究会東京大会 2012)
Education (4)：
- 1992 Kyushu University
- 1992 Kyushu University Graduate School, Division of Agriculture
- 1984 Kyushu University School of Agriculture
- 1984 Kyushu University Faculty of Agriculture
Professional career (2)：
(BLANK)
PhD (Kyushu University)
Work history (3)：
2002 - 2004 Kyushu University Faculty of Agriculture
2004 - Kyushu University Faculty of Agriculture
1992 - 2002 Kyushu University School of Agriculture
Committee career (10)：
2017/03 - 現在 Frontiers in Immunology Specialty Chief Editor of Comparative Immunology section
2015/08 - 現在 日本補体学会 理事
2020/09 - 2022/08 Japanese Association for Developmental and Comparative Immunology President
2012/09 - 2020/08 日本比較免疫学会 副会長
2015/07 - 2018/06 International Society of Developmental and Comparative Immunology Past President
2012/07 - 2015/07 International Society of Developmental and Comparative Immunology President
2009/07 - 2012/07 International Society of Developmental and Comparative Immunology President Elect
2006 - 2012 日本比較免疫学会 庶務役員
2006/07 - 2009/07 International Society of Developmental and Comparative Immunology Vice President, Asia and Oceania
2001 - 2005 日本比較免疫学会 ホームページ委員
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Awards (2)：
2021/09 - 日本補体学会 日本補体学会優秀賞 コイ体表粘液中の補体成分と補体活性化
2015/08 - Japanese Association for Developmental and Comparative Immunology The Furuta Award
Association Membership(s) (6)：
Internation Complement Society
, JAPANESE ASSOCIATION FOR COMPLEMENT RESEARCH
, International Society of Developmental and Comparative Immunology
, 日本比較免疫学会
, 日本魚病学会
, 日本水産学会
