Rchr
J-GLOBAL ID：200901046837018526
Update date: Jan. 30, 2024
Hosoya Ken'ichi
ホソヤ ケンイチ | Hosoya Ken'ichi
Affiliation and department：
Homepage URL (1)：
http://www.pha.u-toyama.ac.jp/phaphzai/index-j.html
Research field (1)：
Clinical pharmacy
Research keywords (5)：
transporter
, blood-brain barrier
, blood-retinal barrier
, Biopharmacy
, Biopharmaceutics
Research theme for competitive and other funds (28)：
- 2022 - 2025 Transport mechanisms of cell-penetrating peptides at the blood-retinal barrier to establish strategies of macromolecular drug delivery
- 2020 - 2023 血液精巣関門インフラックス輸送機構の解明と精巣内薬物送達への応用
- 2020 - 2023 血液網膜関門カチオン性物質輸送に寄与する機構としてのMCT9・14の役割解明
- 2019 - 2022 Establishing ex vivo methods to elucidate efflux transport of drugs at the blood-retinal barrier for retinal drug development
- 2016 - 2019 Molecular mechanisms of transport function at the BBB in epilepsy for normalizing cerebral PGE2 level
- 2016 - 2019 The foundation of developing drugs for retinal diseases by pharmaceutical drug-repositioning screening based on the distribution manner via the blood-retinal barrier
- 2016 - 2018 Evaluation of Cx43 proteins for PGE2 release from retinal pigment epithelial cells for understanding the pathological role in age-related macular degeneration.
- 2014 - 2017 Study of cationic drug efflux across the blood-retinal barrier
- 2013 - 2016 Evaluation of cationic drug transport system at the blood-retinal barrier to deliver the drugs to the retina
- 2012 - 2014 Molecular mechanisms of prostaglandin elimination across brain barriers and its application to neural inflammatory diseases
- 2009 - 2011 Molecular identification and physiological role of brain-type prostaglandin transporter
- 2008 - 2009 血液網膜関門排出輸送に基づくアミロイドβ排出戦略
- 2008 - 2009 健全な神経発達の為に新生児の血液脳関門がもつ機能性脂質供給ルート解明と投与設計
- 2007 - 2007 アミノ酸トランスポーター遺伝子の転写活性調節による網膜血管新生阻害法の開発
- 2006 - 2007 Physiological role of retina-to-blood efflux transport at the inner blood-retinal barrier
- 2003 - 2004 網膜ペリサイト分泌血管内皮細胞増殖抑制因子の同定
- 2003 - 2004 Antioxidants transport via GLUT1 at the blood-retinal barrier
- 2000 - 2003 Development of inner blood-retinal barrier cell lines from transgehic rats harboring temperature-sensitive SV40 large T-antigen gene
- 2000 - 2001 Molecular analysis of cell growth regulating factor in retinal, capillary endothelial cells
- 2000 - 2001 Development of new drug screening system using the blood-brain barrier transporter gene expression
- 2000 - 2001 cDNA cloning of blood-brain barrier neurotransmitter transporter and analysis of its physiological function
- 1998 - 1999 脈絡上皮細胞の培養細胞株の樹立
- 1998 - 1999 血液網膜関門新規実験系の開発と輸送機能解析
- 1998 - 1999 Development of in vitro blood-brain barrier culture system from temperature sensitive SV40T antigen gene transgenic animal
- 1998 - 1999 Functional multiplicity of blood-brain barrier transporters as a detoxifying system of the brain
- 1998 - 1999 血液脳関門における薬剤排出輸送系の生理的意義
- 血液網膜関門における輸送機能解析
- Transport mechanism at the blood-retinal barrier
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Papers (206)：
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Kosuke Tajima, Shin-Ichi Akanuma, Yuki Ohishi, Yukiko Yoshida, Björn Bauer, Yoshiyuki Kubo, Masahiko Inouye, Ken-Ichi Hosoya. Freshly isolated retinal capillaries to determine efflux transporter function at the inner BRB. Journal of controlled release : official journal of the Controlled Release Society. 2022. 343. 434-442
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Katsuki Takashima, Takuya Okada, Atsushi Kato, Yuhei Yamasaki, Takeshi Sugouchi, Shin-ichi Akanuma, Yoshiyuki Kubo, Ken-ichi Hosoya, Hiroyuki Morita, Takuya Ito, et al. Divergent synthesis of decahydroquinoline-type poison-frog alkaloids. ChemistrySelect. 2022. 7. 5. e202104533
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Shin-Ichi Akanuma, Myeongrae Han, Yuka Murayama, Yoshiyuki Kubo, Ken-Ichi Hosoya. Differences in Cerebral Distribution between Imipramine and Paroxetine via Membrane Transporters at the Rat Blood-Brain Barrier. Pharmaceutical research. 2022. 39. 2. 223-237
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Yoshiyuki Kubo, Sakiko Ishizuka, Takeru Ito, Daisuke Yoneyama, Shin-Ichi Akanuma, Ken-Ichi Hosoya. Involvement of TauT/SLC6A6 in Taurine Transport at the Blood-Testis Barrier. Metabolites. 2022. 12. 1
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Takuya Okada, Naizhen Wu, Katsuki Takashima, Jungoh Ishimura, Hiroyuki Morita, Takuya Ito, Takeshi Kodama, Yuhei Yamasaki, Shin-ichi Akanuma, Yoshiyuki Kubo, et al. Total Synthesis of Decahydroquinoline Poison Frog Alkaloids ent-cis-195A and cis-211A. Molecules. 2021. 26. 24. 7529-7529
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MISC (75)：
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久保 義行, 細谷 健一. 血液網膜関門における網膜への薬物輸送メカニズム. Pharm stage. 2017. 17. 1. 73-79
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Yoshiyuki Kubo, Masakazu Yamamoto, Kensuke Matsunaga, Shin-Ichi Akanuma, Ken-Ichi Hosoya. INVOLVEMENT OF PLASMA MEMBRANE MONOAMINE TRANSPORTER (PMAT/SLC29A4) IN RETINA-TO-BLOOD TRANSPORT OF MPP plus ACROSS THE BLOOD-RETINAL BARRIER. DRUG METABOLISM AND PHARMACOKINETICS. 2017. 32. 1. S100-S101
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赤沼 伸乙, 久保 義行, 細谷 健一. タウリンの体内動態とその動態にトランスポーターが果たす役割 (特集 第1回国際タウリン研究会日本部会プロシーディングス). タウリンリサーチ = Japanese journal of taurine research. 2015. 1. 1. 44-46
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Difference and Similarity between Organic Cation Transports at the Blood-Retinal and -Brain Barriers. 2013. 32. 9. 950-954
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HOSOYA Ken-ichi. Biopharmaceutical Approach to the Blood-Retinal Barrier Transport. 2006. 66. 5. 332-337
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Books (24)：
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血液網膜関門における網膜への薬物輸送メカニズム
PHARM STAGE,17, 73-79 2017
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クレアチン前駆体-グアニジノ酢酸(GAA)の体内動態と中枢GABA機能
腎と透析 80, 773-778 2016
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タウリンの体内動態とその動態にタウリントランスポーターが果たす役割
タウリンリサーチ,1,44-46 2015
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The blood-retinal barrier and carnosine, IN: Imidazole Dipeptides: Chemistry, Analysis, Function and Effects, V. R. Preedy (Ed) pp.528-547
The Royal Society of Chemistry 2015
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吸収、わかりやすい生物薬剤学第5版 pp. 13-57
廣川書店 2014
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Education (2)：
- 1983 - 1985 Josai University Graduate School of Pharmaceutical Sciences
- 1979 - 1983 Josai University Faculty of Pharmaceutical Sciences Pharmacy
Professional career (2)：
Work history (13)：
- 2019/04 - 現在 副学長
- 2006/04 - 現在 University of Toyama Graduate School of Medicine and Pharmaceutical Sciences Professor
- 2018/04 - 2019/03 学長補佐
- 2013/10 - 2018/03 University of Toyama Faculty of Pharmaceutical Sciences Dean
- 2009/10 - 2013/09 University of Toyama Faculty of Pharmaceutical Sciences Associate Dean
- 2005/10 - 2006/03 University of Toyama Faculty of Pharmaceutical Sciences Professor
- 2000/10 - 2005/09 Toyama Medical and Pharmaceutical University Faculty of Pharmaceutical Sciences Professor
- 2000/07 - 2000/09 Tohoku University Graduate School of Pharmaceutical Sciences Associate Professor
- 2000/04 - 2000/06 Tohoku University Graduate School of Pharmaceutical Sciences Assistant Professor
- 1999/07 - 2000/03 Tohoku University Graduate School of Pharmaceutical Sciences Assistant Professor
- 1997/04 - 1999/06 Tohoku University Faculty of Pharmaceutical Sciences Instructor
- 1994/03 - 1997/03 University of Southern California Department of Pharmaceutical Sciences Research associate
- 1985/04 - 1994/03 Nikken Chemicals Co., Ltd. Omiya Research Laboratory Research scientist
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Committee career (12)：
- 2008 - 現在 Journal of Pharmaceutical Sciences Editorial Advisory Board
- 2006 - 現在 日本薬剤学会 評議委員/代議員
- 2005 - 現在 日本薬物動態学会 評議委員/代議員
- 2017/04 - 2021/03 日本薬学会 学術誌編集委員長
- 2010/04 - 2020/03 Frontiers in Drug Metabolism and Transport Review Editor
- 2011/01 - 2019/12 Fluids and Barriers of the CNS Editorial Advisory Board
- 2018 - 日本薬剤学会 日本薬剤学会第34年会長
- 2014/04 - 2017/03 日本薬学会 Biological and Pharmaceutical Bulletin Editor-in-Chief /学術誌編集員
- 2011/04 - 2013/03 日本薬学会 Biological and Pharmaceutical Bulletin Section Editor-in-Chief/学術誌編集委員
- 2006 - 2012 Pharmaceutical Research Editorial Advisory Board
- 2009/04 - 2011/03 日本薬学会 Biological and Pharmaceutical Bulletin Section Editor-in-Chief
- 2002 - 2006 Drug Metabolism and Pharmacokinetics Editorial Advisory Board
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Awards (3)：
- 2021/11 - The Japanese Society for the Study of Xenobiotics JSSX Award
- 2020/05 - The Academy of Pharmaceutical Science and Technology, Japan The APSTJ Award
- 2009/11 - American Association of Pharmaceutical Scientists Fellow
Association Membership(s) (5)：
American Association of Pharmaceutical Scientists(AAPS)
, Association for Research in Vision and Ophthalmology(ARVO)
, 日本薬剤学会
, 日本薬物動態学会
, 日本薬学会
