Takeshi Oguchi

Research field (1)： Anesthesiology

Research keywords (3)： protamine , insulin , myocardial ischemia

Research theme for competitive and other funds (9)：

2024 - 2027 GLP-1受容体からみたイリドイド配糖体の心筋虚血再灌流障害に対する心保護作用の解明
2023 - 2026 心筋虚血再灌流障害に対するGLP-1の濃度依存性の心保護作用の解明
2022 - 2025 Effects of intranasal insulin administration for acute cerebral inflammation induced by cardiopulmonary bypass
2021 - 2024 Cardioprotective effect of lactoferrin via PI3K/Akt pathway against stunned myocardium
2020 - 2023 Role of PI3K / Akt pathway on cardioprotective effects of flavonoids against ischemia-reperfusion injury

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Papers (91)：

Yosuke Nakadate, Akiko Kawakami, Takeshi Oguchi, Keisuke Omiya, Hiroyuki Nakajima, Hiroshi Yokomichi, Hiroaki Sato, Thomas Schricker, Takashi Matsukawa. Safety of intranasal insulin administration in patients undergoing cardiovascular surgery: An open-label, nonrandomized, dose-escalation study. JTCVS Open. 2024. 17. 172-182
Keisuke Omiya, Yosuke Nakadate, Hiroaki Sato, Takeshi Oguchi, Toru Matsuoka, Akiko Kawakami, Thomas Schricker, Takashi Matsukawa. Role of the protein kinase A signaling pathway and identification of mediators in the cardioprotective effects of enteral lactoferrin for ischemia-reperfusion injury in an isolated rat heart model. Nutrition. 2023. 113. 112088-112088
Yosuke Nakadate, Akiko Kawakami, Hiroaki Sato, Tamaki Sato, Takeshi Oguchi, Keisuke Omiya, Toru Matsuoka, Thomas Schricker, Takashi Matsukawa. PI3K/Akt pathway mediates the positive inotropic effects of insulin in Langendorff-perfused rat hearts. Scientific Reports. 2022. 12. 1
Keisuke Omiya, Yosuke Nakadate, Takeshi Oguchi, Tamaki Sato, Toru Matsuoka, Masako Abe, Akiko Kawakami, Takashi Matsukawa, Hiroaki Sato. Cardioprotective effects of enteral vs. parenteral lactoferrin administration on myocardial ischemia-reperfusion injury in a rat model of stunned myocardium. BMC Pharmacology and Toxicology. 2022. 23. 1
Yosuke Nakadate, Emi Nakajima, Kodai Ikemoto, Takeshi Oguchi, Takashi Matsukawa. Anesthetic experience does not reduce accidental dural puncture in surgical patients: a retrospective case-controlled study. BMC anesthesiology. 2022. 22. 1. 139-139

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MISC (26)：

山本陸雄, 中楯陽介, 中楯陽介, 大宮啓輔, 川上亜希子, 小口健史, 松川隆. Relationship between intraoperative remifentanil and cerebral regional oxygen saturation in cardiac surgery patients requiring cardiopulmonary bypass. 日本麻酔科学会学術集会(Web). 2023. 70th
大宮啓輔, 中楯陽介, 川上亜希子, 小口健史, 松川隆, 佐藤宏明. Glucose-insulin-normoglycemia therapy decreases surgical site infection following major abdominal surgery: a randomized controlled trial. 日本麻酔科学会学術集会(Web). 2023. 70th
ISHIYAMA Tadahiko, IIJIMA Tetsuya, SUGAWARA Takeshi, OGUCHI Takeshi, KASHIMOTO Satoshi. Effects of 1% Glucose-Containing Ringer's Solution on Intraoperative Plasma Glucose Concentration in Elderly and Young Patients. 2006. 27. 3. 232-235
石山忠彦, 飯嶋哲也, 市川学, 古屋敦司, 吉良聡, 三塚健太郎, 長嶺教光, 福島久史, 三谷茂樹, 菅原健, et al. 術後急性痛の治療. 臨床麻酔. 2005. 29. 1. 75-80
K Masui, S Kashimoto, A Furuya, T Oguchi, T Kumazawa. Free radical scavenger with inhalation anesthetic prevents recovery from ischemia in rat hearts. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2003. 35. 11. A34-A34

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Lectures and oral presentations (40)：

Safety Trial of Intranasal Insulin Administration for Cardiac Surgery Patients: Dose Escalation Study
(American Society of Anesthesiologists Annual Meeting 2022 2022)
Relationship between intraoperative remifentanil and postoperative IL-6 in cardiac surgery patients requiring cardiopulmonary bypass
(2022)
Can Experience Reduce Accidental Dural Puncture?
(American Society of Anesthesiologists Annual Meeting 2021 2021)
Lactoferrin Attenuates Myocardial Ischemia-reperfusion Injury Via Protein Kinase A Pathway
(American Society of Anesthesiologists Annual Meeting 2021 2021)
Airway management of differential lung ventilation for a tracheal stenosis patient caused by large thoracic anterior osteophytes
(The 68th Annual Meeting of the Japanese Society of Anesthesiologists 2021)

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