Rchr
J-GLOBAL ID：200901047176303012   Update date: Apr. 17, 2024

Miyashita Akinori

ミヤシタ アキノリ | Miyashita Akinori
Affiliation and department：
Niigata University Department of Molecular Genetics, Brain Research Institute

About Niigata University Department of Molecular Genetics, Brain Research Institute


Job title： Associate Professor
Homepage URL  (2)： https://www.bri.niigata-u.ac.jp/field/genetics/index.html ,  https://www.bri.niigata-u.ac.jp/en/field/genetics/index.html
Research field  (5)： Neurology ,  Medical biochemistry ,  Genetics ,  Genomics ,  Neuroscience - general
Research keywords  (25)： case-control study ,  human post-mortem brains ,  phase separation ,  RNA binding proteins ,  Stress granules ,  GWAS ,  association study ,  TREM2 ,  SORL1 ,  disease susceptibility genes ,  omics ,  transcriptome ,  FUS ,  APOE ,  microsatellite markers ,  single nucleotide variants ,  frontotemporal lobar degeneration ,  amyotrophic lateral sclerosis ,  Neurodegenerative disease ,  dementia ,  SNP ,  genome ,  Alzheimer's disease ,  SNP<sub>s</sub> ,  Microsatellite
Research theme for competitive and other funds  (29)：
  • 2021 - 2025 Elucidation of novel pathomechanisms specific to brain regions and cell types in tauopathies: a single-cell transcriptome analysis approach
  • 2021 - 2024 Systems pathology approach using deep learning to understand the effect of environmental exposure on the pathogenesis of common diseases
  • 2021 - 2024 Missense rare variant analysis of APOE: Exploring the link between lipid metabolism and Alzheimer's disease
  • 2019 - 2022 網羅的ゲノム解析とインフォマティクス統合解析による認知症の新規病態解析
  • 2018 - 2021 剖検脳・罹患組織を用いたマルチオミックス解析による神経変性タウオパチーの病態解明と創薬標的の同定
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Papers (134)：
  • Masataka Kikuchi, Akinori Miyashita, Norikazu Hara, Kensaku Kasuga, Yuko Saito, Shigeo Murayama, Akiyoshi Kakita, Hiroyasu Akatsu, Kouichi Ozaki, Shumpei Niida, et al. Polygenic effects on the risk of Alzheimer’s disease in the Japanese population. Alzheimer's Research & Therapy. 2024. 16. 1
  • Haruhiko Takahashi, Manabu Natsumeda, Norikazu Hara, Akihide Koyama, Hiroshi Shimizu, Akinori Miyashita, Daiken Satake, Yoshihiro Mouri, Jun Tsukano, Keita Kawabe, et al. Missense mutation of NRAS is associated with malignant progression in neurocutaneous melanosis. Acta neuropathologica communications. 2024. 12. 1. 14-14
  • 宮下哲典, 大日方藍, 他田真理, 阿部学, 柿田明美, 池内健. Search for APOE rare missense variants in a Japanese population. Bio Clinica. 2024. 39. 4
  • Hideki Hayashi, Rie Saito, Hidetomo Tanaka, Norikazu Hara, Shin Koide, Yosuke Yonemochi, Tetsuo Ozawa, Mariko Hokari, Yasuko Toyoshima, Akinori Miyashita, et al. Clinicopathologic features of two unrelated autopsied patients with Charcot-Marie-Tooth disease carrying MFN2 gene mutation. Acta neuropathologica communications. 2023. 11. 1. 207-207
  • 春日 健作, 月江 珠緒, 五十嵐 一也, 石黒 敬信, 宮下 哲典, 小野寺 理, 池内 健. リアルワールドにおける血漿バイオマーカーの有用性の検討. Dementia Japan. 2023. 37. 4. 658-658
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MISC (169)：
  • 齊藤祐子, 宮下哲典, 松原知康, 池内健, 高尾昌樹, 村山繁雄. 凍結保存脳の経年劣化についての検討. 日本神経学会学術大会プログラム・抄録集. 2023. 64th
  • 石黒敬信, 今野卓哉, 原範和, 朱斌, 岡田聡, 柴田護, 雑賀玲子, 北野貴也, 祢津智久, 浜由香, et al. CSF1R関連白質脳症:部分欠失を含む新規CSF1R変異の同定と臨床・画像的特徴. 日本神経学会学術大会プログラム・抄録集. 2023. 64th
  • 春日健作, 月江珠緒, 五十嵐一也, 石黒敬信, 徳武孝允, 宮下哲典, 池内健. 非アルツハイマー型認知症における脳脊髄液アミロイドマーカーの挙動. Dementia Japan. 2022. 36. 4
  • 樋口陽, 樋口陽, YUSRAN Ady Fitrah, 原範和, 種田朝音, 徳武孝允, 三浦健, 岩淵洋平, 五十嵐修一, 林秀樹, et al. 神経核内封入体病(NIID)におけるNOTCH2NLC GGCリピート数と臨床所見,画像所見の比較. Dementia Japan. 2022. 36. 4
  • 宮下 哲典, 原 範和, 尾崎 浩一. 遺伝・ゲノム学 日本人におけるアルツハイマー病感受性遺伝子. 医学のあゆみ. 2020. 274. 8. 675-676
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Books (1)：
  • アルツハイマー病治療の新たなストラテジー
    先端医学社 2022 ISBN:9784865505405
Lectures and oral presentations  (6)：
  • Susceptibility Genes for Dementia: Focusing on APOE
    (Human Genetics Asia 2023: Symposium 7: Aging and Diseases 2023)
  • Single nucleus analysis of human autopsy brains: focus on Alzheimer's disease
    (2023)
  • Transcriptome Analysis of Dementia: Insights from Single Nucleus Analysis of Human Autopsy Brains
    (2022)
  • Transcriptome Analysis of Human Autopsy Brains Reveals Pathophysiology of Dementia
    (2022)
  • APOE genotypes and rare missense variants: potential toward clinical applications
    (2021)
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Education (3)：
  • 1997 - 2000 Niigata University Graduate School, Division of National Science and Technology Doctoral program
  • 1995 - 1997 Niigata University Graduate School of Science and Technology Master’s program
  • 1991 - 1995 Niigata University Faculty of Science Department of Biology
Professional career (1)：
  • PhD (Science) (Niigata University)
Work history (5)：
  • 2018/04 - 現在 Niigata University Department of Molecular Genetics, Brain Research Institute Associate Professor
  • 2006/04 - 2018/03 Niigata University Department of Molecular Genetics, Brain Research Institute Assistant Professor
  • 2014/04 - 2017/03 University of Toronto Tanz Centre for Research in Neurodegenerative Diseases Postdoctoral Research Fellow
  • 2002/04 - 2006/03 Niigata University Department of Molecular Genetics, Brain Research Institute Research Associate
  • 2000/04 - 2002/03 Niigata University Genetic Research Facility Research Associate
Committee career (1)：
  • 2021/11 - 現在 日本認知症学会 代議員
Association Membership(s) (5)：
The Japanese Society for Genome Editing ,  The Japan Society of Human Genetics ,  The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment ,  Japan Society for Dementia Research ,  The Molecular Biology Society of Japan
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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