Rchr
J-GLOBAL ID:200901047209875149   Update date: May. 22, 2020

WAGA Shou

ワガ ショウ | WAGA Shou
Affiliation and department:
Job title: Professor
Homepage URL  (1): http://mcm-www.jwu.ac.jp/~waga/
Research field  (1): Molecular biology
Research keywords  (6): DNA binding ,  G-quadruplex ,  replication origin ,  ORC ,  DNA replication ,  Molecular Biology
Research theme for competitive and other funds  (5):
  • 2015 - 2017 The roles of the G-quadruplex-binding activity of human ORC in replication origin establishment
  • 2015 - Molecular mechanisms for establishment of the replication origins on human chromosomal DNA
  • 2012 - 2014 Analysis of the structure and function of the RNA bound by human ORC
  • 2012 - The potential involvement of RNA in the function at the metazoan replication origins
  • 2009 - 2011 A novel role of RNA in the function at the replication origins in animal cells
Papers (30):
  • Magda Budzowska, Thomas GW Graham, Alexandra Sobeck, Shou Waga, Johannes C Walte. Regulation of the Rev1-Pol ζ complex during bypass of a DNA interstrand crosslink. EMBO J. 2015. 34. 1971-1985
  • Shoko Hoshina, Kei Yura, Honami Teranishi, Noriko Kiyasu, Ayumi Tominaga, Haruka Kadoma, Ayaka Nakatsuka, Tomoko Kunichika, Chikashi Obuse, Shou Waga. Human origin recognition complex binds preferentially to G-quadruplex-preferable RNA and single-stranded DNA. J. Biol. Chem. 2013. 288. 42. 30161-30171
  • Lena R. Kundu, Masayuki Seki, Nanae Watanabe, Hiromu Murofushi, Asako Furukohri, Shou Waga, Alan J. Score, J. Julian Blow, Masami Horikoshi, Takemi Enomoto, Shusuke Tada. Biphasic chromatin binding of histone chaperone FACT during eukaryotic chromatin DNA replication. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 2011. 1813. 6. 1129-1136
  • Lena R. Kundu, Yuji Kumata, Naoko Kakusho, Saori Watanabe, Asako Furukohri, Shou Waga, Masayuki Seki, Hisao Masai, Takemi Enomoto, Shusuke Tada. Deregulated Cdc6 inhibits DNA replication and suppresses Cdc7-mediated phosphorylation of Mcm2-7 complex. NUCLEIC ACIDS RESEARCH. 2010. 38. 16. 5409-5418
  • Christopher Van, Shan Yan, W. Matthew Michael, Shou Waga, Karlene A. Cimprich. Continued primer synthesis at stalled replication forks contributes to checkpoint activation. JOURNAL OF CELL BIOLOGY. 2010. 189. 2. 233-246
more...
Lectures and oral presentations  (55):
  • Analyses of the function of the N-terminal region of human ORC1
    (2017)
  • Analyses of transcription-dependent DNA binding of AlF-C2
    (2017)
  • Biochemical analyses of the ORC-ORCA interaction
    (2017)
  • Further characterization of the binding of human ORC to G-quadruplex-formable single-stranded DNA
    (Cold Spring Harbor Laboratory Meeting on Eukaryotic DNA Replication and Genome Maintenance 2017)
  • Analyses of ssDNA binding activity of the ORC mutants
    (2016)
more...
Education (2):
  • - 1991 Tohoku University Graduate School, Division of Agriculture Department of Agricultural Chemistry
  • - 1985 Tohoku University Faculty of Agriculture
Professional career (1):
  • Doctor of Agriculture (Tohoku University)
Work history (5):
  • 2002 - 2008 Osaka University
  • 2008 - Japan Women's University
  • 1998 - 2002 Osaka University
  • 1991 - 1995 Staff Investigator, Cold Spring Harbor Laboratory, USA
  • 1990 - 1992 Postdoctoral fellow, Cold Spring Harbor Laboratory, USA
Association Membership(s) (3):
Japanese Cancer Association ,  The Molecular Biology Society of Japan ,  The Japanese Biochemical Society
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