Rchr
J-GLOBAL ID：200901048003935117
Update date: Jan. 30, 2024
Kuwahara Masayoshi
クワハラ マサヨシ | Kuwahara Masayoshi
Affiliation and department：
Job title：
Professor
Research field (1)：
Veterinary medicine
Research theme for competitive and other funds (23)：
- 2020 - 2023 自律神経とその幹細胞に着目した抗がん剤の遅発性心毒性の病態解明
- 2017 - 2020 Effects of nursing interventions increasing parasympathetic nervous activity in chronic disease patients
- 2016 - 2019 The role of Ca2+ homeostasis in hippocampal synaptic transmission and plasticity
- 2015 - 2018 Development of animal models for safety assessment of drugs using genome editing technology and its application
- 2014 - 2017 Development of the method for status assesment of cattle by monitoring sleep stage.
- 2010 - 2012 Chronobiological study for role of nervous and immune systems in sleep regulation
- 2004 - 2005 THE RELEVANCE OF THE SELECTIVE DAMAGE OF PURKINJE FIBER AND THE ABNORMAL ELECTROCARDIOGRAM IN CANINE X-LINKED MUSCLAR DYSTROPHY
- 2003 - 2005 Development of objective criteria of pain in animals.
- 2001 - 2003 Effects of diesel exhaust particulate (DEP) on genital organs and cardiovascular system
- 2001 - 2003 Mechanisms of chemical-induced fetal brain toxicity
- 2000 - 2000 ディーゼル排気ガス粒子(DEP)の循環機能ならびに胎児毒性に関する基礎的研究
- 1999 - 2000 Chronobiological study on interactions between cardiovascular and neuroimmunological function
- 1997 - 1998 中皮細胞と内皮細胞のバリアー機能に関する研究
- 1995 - 1997 Basic research in pathophysiological mechanisms on airway hypersensitivity
- 1996 - 1996 中皮細胞の機械的伸展に対する細胞応答性に関する研究
- 1995 - 1995 中皮細胞の物質透過性調節に関する研究
- 1993 - 1993 中皮細胞に対する生理活性物質の影響
- 1993 - 1993 鼻・喉頭粘膜におけるC線維の感覚受容機構と神経ペプチドの放出に関する研究
- 1992 - 1993 Establishment of noninvasive analytical methods for autonomic nervous function in mammals and their application
- 心拍変動スペクトル解析による自律神経機能の評価に関する研究
- 中皮細胞の機能に関する研究
- Studies on evaluation of autonomic nervous functions by analysis of heart rate variability.
- Studies on functions of mesothelial cells.
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Papers (80)：
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Akitoshi Chikamoto, Ryota Tochinai, Shin-Ichi Sekizawa, Masayoshi Kuwahara. Plasticity occurs in a specific phenotype of neurons in the nucleus tractus solitarius of dystrophin gene-mutated rats. The European journal of neuroscience. 2023
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Ryota Tochinai, Koichi Kimura, Takeru Saika, Wataru Fujii, Hiroyuki Morita, Koki Nakanishi, Yoshiharu Tsuru, Shin-Ichi Sekizawa, Keitaro Yamanouchi, Masayoshi Kuwahara. Ivabradine ameliorates cardiomyopathy progression in a Duchenne muscular dystrophy model rat. Experimental animals. 2023
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Ryota Tochinai, Yoshiyasu Nagashima, Shin-Ichi Sekizawa, Masayoshi Kuwahara. Anti-tumor and cardiotoxic effects of microtubule polymerization inhibitors: The mechanisms and management strategies. Journal of applied toxicology : JAT. 2023
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Haruka Orihara, Min Ma, Yoshiyasu Nagashima, Ryota Tochinai, Shin-Ichi Sekizawa, Daiki Kato, Masahiro Shinada, Susumu Aoki, Naoki Fujita, Takayuki Nakagawa, et al. Co-administration of JQ1, a bromodomain-containing protein 4 inhibitor, enhances the antitumor effect of combretastatin A4, a microtubule inhibitor, while attenuating its cardiotoxicity. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023. 160. 114353-114353
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Yoshiyasu NAGASHIMA, Ryota TOCHINAI, Shin-ichi SEKIZAWA, Daiki KATO, Takayuki NAKAGAWA, Yoshiharu TSURU, Yasuko TATEWAKI, Tatsushi MUTOH, Yasuyuki TAKI, Masayoshi KUWAHARA. Pretreatment with tadalafil attenuates cardiotoxicity induced by combretastatin A4 disodium phosphate in rats. Journal of Toxicologic Pathology. 2023
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MISC (117)：
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Kentaro Kaneko, Akitoshi Chikamoto, Julia Chu-Ning Hsu, Ryota Tochinai, Shin-Ichi Sekizawa, Machiko Yamamoto, Masayoshi Kuwahara. Effects of environmental enrichment on autonomic nervous activity in NSY mice. Experimental animals. 2019
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Akitoshi Chikamoto, Shin-Ichi Sekizawa, Ryota Tochinai, Masayoshi Kuwahara. Early attenuation of autonomic nervous function in senescence accelerated mouse-prone 8 (SAMP8). Experimental animals. 2019. 68. 4. 511-517
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栃内 亮太, 小松 加代子, 村上 純太, 永田 百合子, 安藤 稔, 畑 千恵, 鈴木 倫, 角 将一, 小林 稔秀, 桑原 正貴. 微小管重合阻害薬combretastatin A4 disodium phosphateの単回投与によりラットに誘発される心筋障害. 日本毒性病理学会講演要旨集. 2018. 34回. 77-77
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桑原 正貴, 遠藤 麻衣子, 鈴木 一美, 李 俊佑, 潮 奈々子, チェンバーズ・ジェームズ, 内田 和幸, 中山 裕之. 老齢競走馬における心臓の機能的および病理組織学的解析の1例. 日本獣医麻酔外科学雑誌. 2016. 47. Suppl.2. 230-230
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Sakiko Taniguchi, Masakazu Hanafusa, Hirokazu Tsubone, Haruka Takimoto, Daisuke Yamanaka, Masayoshi Kuwahara, Koichi Ito. Age-dependency of the serum oxidative level in the senescence-accelerated mouse prone 8. Journal of Veterinary Medical Science. 2016. 78. 8. 1369-1371
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Books (4)：
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スラッタ-小動物の外科手術 ショック : 循環血液量減少と敗血症の病態生理と治療 呼吸器系の病態生理 呼吸器手術症例に対する評価(共訳)
文永堂 2000
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Reproducibility of circadian rhythm of heart rate variability in miniature swine. In : Electrocardiology'96
J. Liebman Ed. World Scientific, Singapore 1997
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新畜産ハンドブック
講談社 サイエンティフィク 1995
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獣医生理学
文永堂 1994
Education (2)：
- - 1987 The University of Tokyo
- - 1983 Tohoku University Faculty of Agriculture
Professional career (2)：
- (BLANK) (The University of Tokyo)
- (BLANK) (The University of Tokyo)
Work history (4)：
- 2012 - 現在 The University of Tokyo Professor
- 2007 - 2012 The University of Tokyo
- 1998 - 2007 The University of Tokyo Associate Professor
- 1988 - 1998 The University of Tokyo
Committee career (5)：
- 日本心電学会 評議員
- 日本獣医循環器学会 理事
- 日本畜産学会 理事
- 日本実験動物学会 理事
- 日本獣医学会 評議員
Association Membership(s) (7)：
日本心電学会
, 日本ウマ科学会
, 日本獣医循環器学会
, 日本畜産学会
, 日本実験動物学会
, 日本獣医学会
, アメリカ胸腔学会(American Tholacic Society)
