Rchr

J-GLOBAL ID：200901048872191080 Update date: Mar. 30, 2024

Nishida Naoshi

ニシダナオシ | Nishida Naoshi

Affiliation and department：
Homepage URL (1)： http://www.med.kindai.ac.jp/shoukaki/index.html

Research field (3)： Biological, health, and medical informatics , Genomics , Gastroenterology

Research keywords (9)： data base , artificial Intelligence , Molecular Biology , Hepatology , Gastroenterology , Epigenetics , chromosome , tumor suppressor gene , Hepatocellular carcinoma

Research theme for competitive and other funds (35)：

2024 - 2027 胆道癌のドライバー変異に着目した腫瘍免疫微小環境の再構築と治療最適化
2022 - 2025 免疫チェックポイント阻害剤投与に伴う急速な腫瘍増大(HPD)の発症機序の解析
2021 - 2024 Analysis of immunological microenvironment of tumor and effect of smoking habits for the development of personalized medicine in liver cancer
2021 - 2024 Development of AI-aided US diagnosis system for liver tumor
2021 - 2024 Identification of resistant clone for the chemotherapy of hepatocellular carcinoma using cell free DNA

2021 - 2024 Development of AI for the drug therapy of hepatocellular carcinoma using medical image and immunogenomics

2018 - 2021 Effect of tyrosine kinase inhibitor for immunological microenviroment of hepatocellular carcinoma

2018 - 2021 Preemptive Medicine to Solid Tumors based on Epigenomics

2020 - 2021 Prediction of anti-tumor response to systemic chemotherapy with machine learning using images for hepatocellular carcinoma

2019 - 2021 Construction of national database for US digital image and development of AI-aided US diagnosis system

2016 - 2019 Identification of metastasis-associated genes based on methylome and chromosome analyses and it's clinical application

2018 - 2019 Construction of nationwide database of ultrasound image for fusion of artificial intelligence and diagnostic ultrasound imaging

2017 - 2019 生活習慣病を基盤とした肝発癌における喫煙の影響、及びバイオマーカーの開発に関する研究

2015 - 2018 Development of biomarker for sorafenib treatment using serum microRNA in patients with hepatocellular carcinoma

2016 - 2018 メチローム・クロモゾーム解析に基づく肝癌転移関連分子の同定と臨床応用

2016 - 2016 慢性ウイルス性肝炎の病態把握 :重症度・治療介入時期・治療効果判定・予後予測のための非侵襲的病態診断アルゴリズムの確立

2012 - 2015 Identification of risk factors of hepatocarcinogenesis in fatty liver disease through the comprehensive analysis of epigenetic alterations

2012 - 2015 エピゲノム変異からみたヒト肝発癌における喫煙の影響とGST遺伝子多型に関する研究

2012 - 2013 分岐鎖アミノ酸の酸化ストレス及びエピゲノム変異を介した肝発癌に及ぼす影響に関する研究

2011 - 2013 Impact of genomic alterations on the clinical outcome of systemic chemotherapy for patients with gastrointestinal cancer

2009 - 2011 Prediction of tumor dynamics using amountof serum methylated DNA in human hepatocellular carcinoma

2011 - エピゲノム異常に基づいた肝発癌予測システムの開発

2009 - 2010 ナトリウム利尿ペプチド系活性化による新規の肥満・脂肪肝炎治療法開発の基盤研究

2008 - 2010 Impact of gene silencing on the recurrence of hepatocellular carcinoma after living-donor liver transplantation

2007 - 2009 Analysis of epigenetic instability of liver disease at promoter of cancer-related gene and their clinical implication

2008 - 肝発癌経過における遺伝子メチル化とC型肝炎ウイルスとの関連に関する研究

2008 - 遺伝子メチル化を用いた大腸癌化学療法の効果予測マーカーの開発

2003 - 2004 肝細胞癌における肝移植後の転移再発予測システムの確立

2002 - 2003 Analysis of Aberration for molecules of p53-depandent Apoptosis in hepatocellular carcinoma and Gastrointestinal Cancer

1999 - 2001 Analyses of RB pathway molecules in human hepatocellular carcinoma.s.

1999 - 2000 肝炎による肝発癌機構の解明及び遺伝子診断への応用に関する研究

1997 - 1999 TGF-βシグナル伝達に関わる分子の消化器癌における異常の解析及び癌治療への応用

1997 - ヒト肝細胞癌の遺伝子診断に関する研究

1994 - 肝細胞癌の悪性度評価としての癌抑制遺伝子の検討

1993 - Accumulation of allelic loss on chromosomal arms 13q, 16q and 17p in the advanced stages of human hepatocellular carcinoma

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Papers (313)：

Margherita Rimini, Bernardo Stefanini, Toshifumi Tada, Goki Suda, Shigeo Shimose, Masatoshi Kudo, Fabian Finkelmeier, Changhoon Yoo, José Presa, Elisabeth Amadeo, et al. Impact of body mass index on the prognosis of unresectable HCC patients receiving first-line Lenvatinib or atezolizumab plus bevacizumab. Liver international : official journal of the International Association for the Study of the Liver. 2024
Satoru Hagiwara, Toru Takase, Itsuki Oda, Yoriaki Komeda, Naoshi Nishida, Akihiro Yoshida, Tomoki Yamamoto, Takuya Matsubara, Masatoshi Kudo. Hereditary hemorrhagic telangiectasia with hepatic arteriovenous shunt diagnosed due to liver damage. Clinical Journal of Gastroenterology. 2024
Lorenz Balcar, Bernhard Scheiner, Claudia Angela Maria Fulgenzi, Antonio D'Alessio, Katharina Pomej, Marta Bofill Roig, Elias Laurin Meyer, Jaekyung Che, Naoshi Nishida, Pei-Chang Lee, et al. A meta-analysis and real-world cohort study on the sex-related differences in efficacy and safety of immunotherapy for hepatocellular carcinoma. JHEP reports : innovation in hepatology. 2024. 6. 2. 100982-100982
Tomoko Aoki, Masatoshi Kudo, Kazuomi Ueshima, Masahiro Morita, Hirokazu Chishina, Masahiro Takita, Satoru Hagiwara, Hiroshi Ida, Yasunori Minami, Masakatsu Tsurusaki, et al. Incidence of Hyper Progressive Disease in Combination Immunotherapy and Anti-Programmed Cell Death Protein 1/Programmed Death-Ligand 1 Monotherapy for Unresectable Hepatocellular Carcinoma. Liver cancer. 2024. 13. 1. 56-69
Silvia Camera, Margherita Rimini, Federico Rossari, Toshifumi Tada, Goki Suda, Shigeo Shimose, Masatoshi Kudo, Changhoon Yoo, Jaekyung Cheon, Fabian Finkelmeier, et al. Safety and Efficacy of Lenvatinib in Very Old Patients with Unresectable Hepatocellular Carcinoma. Targeted oncology. 2024. 19. 1. 29-39

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MISC (348)：

西田直生志. AIを基盤とした超音波検査の未来像肝腫瘤診断における新たな可能性と展望. 日本がん検診・診断学会誌. 2023. 31. 1. 98-98
萩原智, 西田直生志, 工藤正俊. B型肝炎診療の未来予想図(現状と課題) 免疫チェックポイント阻害剤投与に伴うHBV再活性化および抗ウイルス効果についての検討. 肝臓. 2023. 64. Suppl.1. A51-A51
萩原智, 西田直生志, 工藤正俊. 遺伝・代謝性肝疾患の未来予想図(現状と課題) Erythropoietic porphyria(EPP)関連肝障害における瀉血治療の有効性. 肝臓. 2023. 64. Suppl.1. A111-A111
萩原智, 西田直生志, 工藤正俊. NASH/ASHの病態解明とTransrational Research 非アルコール性脂肪肝疾患におけるDNAメチル化に関連する臨床的・病理学的特徴. 肝臓. 2023. 64. Suppl.1. A208-A208
有山武尊, 萩原智, 西田直生志, 工藤正俊. 非硬変肝から発生したFontan術後HCCの1例. 肝臓. 2023. 64. Suppl.1. A324-A324

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Books (22)：

Immunotherapy in Hepatocellular Carcinoma
MDPI Books 2023 ISBN:9783036566917
Treatment of HCC using Atezolizumab+Bevacizumab
2021
AI diagnosis for Ultrasonography
2021 ISBN:9784274225765
US diagnosis for Ultrasonography
2021 ISBN:9784274225765
US diagnosis for Ultrasonography
2021 ISBN:9784274225765

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Lectures and oral presentations (493)：

Development and Prospects of AI-aided Ultrasonography (US) System - New Possibilities in Diagnosis of Liver Tumor -
(The 33rd Annual Meeting of APASL (Asian Pacific Association for Study of the Liver): Bridging Clinical and Basic Research 2024)
The roles of angiogenesis inhibitors and immune checkpoint inhibitors in the treatment of liver cancer.
(2024)
AI支援による超音波検査システムの開発と展望 -肝腫瘤診断における新たな可能性-
(第42回東海超音波研究会特別講演 2024)
Non-inflamed typeの胆管癌における抗原提示分子のメチル化と発現低下
(第45回日本肝臓学会西部会:ワークショップ3 予後改善に向けた胆管癌の集学的治療 2023)
切除不能HCCに対するABC conversion療法とclinical CRの現状
(第45回日本肝臓学会西部会: ワークショップ1 肝がん局所療法の多様性とその到達点 2023)

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Education (2)：

- 1993 Kyoto University Graduate School of Medicine
- 1985 Osaka Medical College Faculty of Medicine Division of Medicine

Professional career (1)：

M.D, Ph.D. (Kyoto University Graduate School of Medicine)

Work history (6)：

2021/04 - 現在 Kindai University Faculty of Medicine Professor
2011/08 - 2021/03 Fuculty of Medicine Kindai University Department of Gastroenterology and Hepatology Associate Professor
2006/08 - 2011/07 Kyoto University Graduate School of Medicine Department of Gastroenterology and Hepatology Assistant Professor/Lecture
2004/02 - 2006/07 Baylor University Medical Center Division of Gastroenterology Reserach Associate
1997/04 - 2004/01 Kyoto University Graduate School of Medicine Department of Medicine and Clinical Science Assistant Professor

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Committee career (16)：

2023/12 - 現在 Swiss National Science Foundation (SNSF) External Reviewer
2022/11 - 現在 JSUM health committee member
2022/04 - 現在 The Japan Society of Hepatology Member of COI committee
2020/04 - 現在 Japan Society of Hepatology Movement for Fight against Liver Cancer, Person in Charge, Osaka Prefecture
2020/04 - 現在 The Japan Society of Ultrasonics in Medicine Committee member for construction of US image database and development of US-AI

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Awards (19)：

2022/06 - The Japan Society of Hepatology Hepatology Research Citation Award Immune checkpoint blockade for the treatment of human hepatocellular carcinoma
2021/04 - Smoking Resarch Foundation Research Grant Analysis of immunological microenvironment of liver cancer
2020/04 - National Institute of Informatics ROIS NII Open Collaborative Research 2020 Artificial intelligence for prediction of outcome after chemotherapy in patients with hepatocellular carcinoma
2017/04 - 公益財団法人喫煙科学研究財団一般研究助成
2012/06 - 財団法人ひと・健康・未来研究財団研究助成(医学分野)

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Association Membership(s) (10)：

米国消化器病学会 , 日本高齢消化器病学会 , THE JAPAN SOCIETY FOR CLINICAL IMMUNOLOGY , THE JAPAN SOCIETY OF ULTRASONICS IN MEDICINE , JAPAN GASTROENTEROLOGICAL ENDOSCOPY SOCIETY , 日本分子生物学会 , 日本癌学会 , 日本消化器病学会 , 日本肝臓学会 , 日本内科学会

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