Rchr
J-GLOBAL ID：200901049241691176   Update date: Jan. 08, 2026

Rikinari HANAYAMA,

ハナヤマ リキナリ | Rikinari HANAYAMA,
Affiliation and department：
Kanazawa University, Professor, WPI Nano Life Science Institute (NanoLSI)

About Kanazawa University, Professor, WPI Nano Life Science Institute (NanoLSI)


Other affiliations (1)：
Homepage URL  (2)： http://immunology.w3.kanazawa-u.ac.jp ,  http://immunology.w3.kanazawa-u.ac.jp/index2.html
Research field  (3)： Medical biochemistry ,  Physiology ,  Immunology
Research keywords  (5)： Exosome ,  Extracellular Vesicle ,  Immunoregulation ,  Neurodegeneration ,  Tumor Progression
Research theme for competitive and other funds  (30)：
  • 2024 - 2029 Development of active targeting methods using designer exosomes
  • 2024 - 2028 Elucidation of bio-regulatory mechanisms by brain-derived exosomes
  • 2024 - 2027 Establishment of mass production and quality control technology for high quality exosome formulations
  • 2023 - 2027 Exosomes derived from intestinal bacteria and their prophylaxis in bronchial asthma caused by chemicals in the environment.
  • 2024 - 2026 Development of designer exosomes that induce cancer antigen-specific cellular immunity
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Papers (66)：
  • Shota Imai, Kanto Nagamori, Uryo Onishi, Xiabing Lyu, Iriya Fujitsuka, Makie Ueda, Tomoyoshi Yamano, Rikinari Hanayama. Induction of antigen-specific regulatory T cells by engineered extracellular vesicles. Drug Delivery. 2025. 32. 1. 2586305-2586305
  • Takehiko Ichikawa, Yohei Kono, Makiko Kudo, Takeshi Shimi, Naoyuki Miyashita, Tomohiro Maesaka, Kojiro Ishibashi, Kundan Sivashanmugan, Takeshi Yoshida, Keisuke Miyazawa, et al. Probing Nanomechanics by Direct Indentation Using Nanoendoscopy-AFM Reveals the Nuclear Elasticity Transition in Cancer Cells. ACS applied nano materials. 2025. 8. 42. 20239-20249
  • Ryouken Kimura, Tomoyoshi Yamano, Uryo Onishi, Xiabing Lyu, Kanto Nagamori, Toan Van Le, Mitsutoshi Nakada, Rikinari Hanayama. Selective expansion and differentiation of antigen-specific CD4+ T-helper cells by engineered extracellular vesicles. Drug Delivery. 2025. 32. 1. 2509969
  • Xiabing Lyu, Tomoyoshi Yamano, Kanto Nagamori, Shota Imai, Toan Van Le, Dilireba Bolidong, Makie Ueda, Shota Warashina, Hidefumi Mukai, Seigo Hayashi, et al. Direct delivery of immune modulators to tumour-infiltrating lymphocytes using engineered extracellular vesicles. Journal of Extracellular Vesicles. 2025. 14. 4. e70035
  • Muhammad Isman Sandira, Keesiang Lim, Takeshi Yoshida, Elma Sakinatus Sajidah, Shinnosuke Narimatsu, Reon Imakawa, Kota Yoshimura, Goro Nishide, Yujia Qiu, Azuma Taoka, et al. Nanoscopic Profiling of Small Extracellular Vesicles via High-Speed Atomic Force Microscopy (HS-AFM) Videography. Journal of Extracellular Vesicles. 2025. 14. 4. e270050
ｍore...
MISC (26)：
  • Shota Imai, Tomoyoshi Yamano, Rikinari Hanayama. Extracellular vesicles engineering and therapeutic applications. The Cell. 2025. 57. 10. 18-21
  • Hiromu Tanimoto, Kouyuki Hirayasu, Rikinari Hanayama. Association of human innate immune receptors with autoimmune and inflammatory diseases. Clinical Immunology & Allergology. 2025. 84. 1. 1-7
  • Rikinari Hanayama, Takafumi Seto. Elucidation and Regulation of Biological Responses by Fine Particles. Journal of Japanese Society for Atmospheric Enivronment. 2025. 60. 1. 24-25
  • Shota Imai, Tomoyoshi Yamano, Rikinari Hanayama. Immunoregulation by extracellular vesicles (Japanese). Journal of Clinical and Experimental Medicine. 2024. 291. 9. 668-672
  • Xiabing Lyu, Tomoyoshi Yamano, Rikinari Hanayama. Exosome-based Nucleic Acid Therapeutics (Japanese). Drug Delivery System. 2024. 39. 5. 346-353
ｍore...
Patents (8)：
  • Compounds for promoting the secretion of extracellular vesicles
  • Compositions for regulating CAR-T cell activation, hematopoietic stem cell proliferation, and iPS cell differentiation, and use thereof
  • Immunoregulatory method, nucleic acid for immunoregulation and use thereof 2
  • Immunoregulatory method, nucleic acid for immunoregulation and use thereof 1
  • Antigen-presenting extracellular vesicles
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Books (13)：
  • Extracellular Fine Particles
    Springer 2025
  • Experimental Medicine: Neurodegenerative diseases
    Yodosha 2023
  • Experimental Medicine: New Macrophage
    Yodosha 2022
  • Experimental Medicine: Biology of EVs
    Yodosha 2021
  • Experimental Medicine: New Generation Flow Cytometry
    Yodosha 2021
ｍore...
Lectures and oral presentations  (133)：
  • Special Lecture, Japan Biological Informatics Consortium
    (Online 2026)
  • Special Lecture, Center for iPS Research, Kyoto University
    (Kyoto 2026)
  • CIC Tokyo Thursday Gathering
    (Tokyo 2025)
  • Special Seminar, Osaka Metropolitan University
    (Osaka 2025)
  • Invited Seminar, Osaka Children's Hospital
    (Osaka 2025)
ｍore...
Education (3)：
  • 2000 - 2004 Ph.D, Osaka University (Advisor: Prof. Shigekazu Nagata)
  • 1993 - 1999 MD, Osaka University
  • 1990 - 1993 Takatsuki High School
Professional career (1)：
  • MD, PhD (Osaka University)
Work history (12)：
  • 2019 - 現在 Coordinator, WISE Program for Nano-Precision Medicine, Science, and Technology, Kanazawa University
  • 2017 - 現在 Professor, WPI Nano Life Science Institute, Kanazawa University
  • 2015 - 現在 Professor, Department of Immunology, Graduate School of Medical Sciences, Kanazawa University
  • 2018 - 2025 JST CREST Investigator
  • 2015 - 2017 Program Officer, KAKENHI, MEXT
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Committee career (13)：
  • 2024 - 現在 Advisor, MEXT Q-LEAP Program
  • 2023 - 現在 Acting Member, Research Funding Subcommittee, Council for Science and Technology, MEXT
  • 2020 - 現在 JST FOREST Program Director Committee Member
  • 2019 - 現在 Advisor, FUJIFILM Wako
  • 2019 - 現在 Councilor, The Japanese Society for Immunology
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Awards (10)：
  • 2021 - JB Reviewer Award
  • 2019 - Kanazawa University Meritorious Award
  • 2014 - Osaka University President's Commendation
  • 2013 - Osaka University President's Award
  • 2012 - Astellas Biomedical Award
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Association Membership(s) (5)：
International Society for Extracellular Vesicles ,  Japanese Society for Extracellular Vesicles ,  The Japanese Society of Drug Delivery System ,  The Japanese Society for Immunology ,  The Japanese Biochemical Society
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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