Rchr
J-GLOBAL ID：200901049403950472   Update date: Mar. 31, 2024

Oka Natsuhisa

オカ ナツヒサ | Oka Natsuhisa
Affiliation and department：
Gifu University Faculty of Engineering, Department of Chemistry and Biomolecular Science

About Gifu University Faculty of Engineering, Department of Chemistry and Biomolecular Science


Job title： Professor
Other affiliations (4)：
  • Gifu University  iGCORE   Professor
  • Gifu University  Center for One Medicine Innovative Translational Research   Professor
  • Gifu University  Artificial Intelligence Advanced Research Center   Professor
  • Gifu University  Gu Composites Center   Professor
Homepage URL  (1)： https://www1.gifu-u.ac.jp/~oka_ap/
Research field  (5)： Bioorganic chemistry ,  Molecular biochemistry ,  Synthetic organic chemistry ,  Pharmaceuticals - chemistry and drug development ,  Biochemistry
Research keywords  (34)： unsaturated carbocycle ,  organosilicon compounds ,  heteroatom ,  nucleic acid ,  carbohydrate ,  synthetic chemistry ,  Nucleic acid chemistry ,  有機合成化学 ,  核酸化学 ,  酵素応答性分子 ,  アデニロコハク酸合成酵素 ,  ヌクレオシド ,  リン原子修飾DNA類縁体 ,  ホスホロアミダイト ,  不斉合成 ,  固相合成 ,  立体選択的 ,  オキサザボスホリジン ,  リン原子修飾DNA ,  リン原子修飾核酸 ,  蛍光プローブ ,  立体選択性 ,  ホスホロアミデート ,  イノシン ,  核酸の生合成 ,  CTP合成酵素 ,  ホスファイト ,  蛍光標識化 ,  H-ホスホネート ,  カルボニル基のリン酸化 ,  ホスホロチオエート ,  ヌクレオチド ,  DNA ,  核酸医薬
Research theme for competitive and other funds  (16)：
  • 2021 - 2024 新規ドミノ反応を用いる多置換不飽和環状炭化水素の立体選択的合成法の開発
  • 2018 - 2024 化学を基盤とするゲノムスケールDNA合成技術の開発
  • 2017 - 2020 A study on the biosynthesis of guanosine monophosphate and the development of functional molecules targeting guanosine monophosphate synthetase
  • 2013 - 2016 Stereoselective synthesis of alkenes using new Julia-type reagents
  • 2014 - 2016 カルボニル基のリン酸化反応を利用した核酸の生合成中間体の合成法の開発
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Papers (55)：
  • Kohei Nomura, Kaoru Onda, Hirotaka Murase, Fumitaka Hashiya, Yukiteru Ono, Goro Terai, Natsuhisa Oka, Kiyoshi Asai, Daisuke Suzuki, Naho Takahashi, et al. Development of PCR Primer Enabling the Design of Flexible Sticky Ends for Efficient Concatenation of Long DNA Fragments. RSC Chemical Biology. 2024. Accepted Manuscript
  • Hashiya, F, Murase, H, Chandela, A, Hiraoka, H, Inagaki, M, Nakashima, Y, Abe, N, Nakamura, M, Terai, G, Kimura, Y, et al. The effect of γ phosphate modified deoxynucleotide substrates on PCR activity and fidelity. ChemBioChem. 2023. 24. 14. e202200572
  • Natsuhisa Oka, Mayuka Kanda, Minami Furuzawa, Wakaba Arai, Kaori Ando. Synthesis of Truncated Carbocyclic Nucleosides Using 5′-Deoxy-5′-Heteroarylsulfonylnucleosides. Current Protocols in Nucleic Acid Chemistry. 2022. 2. 3. e398
  • Natsuhisa Oka, Mayuka Kanda, Minami Furuzawa, Wakaba Arai, Kaori Ando. Serendipitous One-Step Synthesis of Cyclopentene Derivatives from 5′-Deoxy-5′-heteroarylsulfonylnucleosides as Nucleoside-Derived Julia-Kocienski Reagents. The Journal of Organic Chemistry. 2021. 86. 16684-16698
  • Natsuhisa Oka, Hiroki Hirabayashi, Kota Kumada, Kaori Ando. Synthesis of xanthosine 2-phosphate diesters via phosphitylation of the carbonyl group. Bioorganic & Medicinal Chemistry Letters. 2021. 54. 128439-128439
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MISC (57)：
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Patents (6)：
  • シクロペンテン誘導体及びシクロペンテン誘導体の製造方法
  • 5'-ホスフィチル化モノマーおよびH-ホスホネートオリゴヌクレオチド誘導体の製造方法
  • 糖1-ボラノホスフェート化合物の立体選択的製造方法
  • 糖1-リン酸化合物の製造方法
  • 糖ボラノホスフェート化合物及びその用途
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Books (1)：
  • 複合糖質の化学と最新応用技術 第3章 糖-1-リン酸誘導体の化学合成
    2009
Lectures and oral presentations  (7)：
  • 創薬への応用を志向したリン原子修飾核酸の立体選択的合成
    (第2回東海地区創薬デザイン研究会 2023)
  • Stereocontrolled synthesis of P-chiral oligonucleotide analogs for therapeutic applications
    (IKM Organic & Biomolecular Chemistry Seminar Series 2023 2023)
  • Stereoselective furanosylation reactions for the synthesis of oligosaccharides and nucleosides
    (The 8th International Conference of The Indonesian Chemical Society (ICICS) 2019 2019)
  • Stereocontrolled Synthesis of P-Chiral Oligonucleotides
    (International Symposium on Pure & Applied Chemistry 2017 (ISPAC 2017) 2017)
  • Stereocontrolled synthesis of P-chiral oligonucleotide analogs
    (1st Joint International Seminar of Faculty of Science and Technology (Universiti Kebangsaan Malaysia) and Faculty of Engineering (Gifu University) 2014 (Gifu University) 2014)
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Education (4)：
  • 2000 - 2003 The University of Tokyo Graduate School of Engineering Department of Chemistry and Biotechnology
  • 1998 - 2000 The University of Tokyo Graduate School of Engineering Department of Chemistry and Biotechnology
  • 1996 - 1998 The University of Tokyo The Faculty of Engineering Department of Chemistry and Biotechnology
  • 1994 - 1996 The University of Tokyo
Professional career (3)：
  • Ph.D. (The University of Tokyo)
  • M.S. (The University of Tokyo)
  • B.S. (The University of Tokyo)
Work history (11)：
  • 2023/04 - 現在 Gifu University Faculty of Engineering, Department of Chemistry and Biomolecular Science Professor
  • 2023/01 - 現在 Center for One Medicine Innovative Translational Research, Gifu University Institute for Advanced Study Division of innovative modality development
  • 2020 - 現在 Institute for Glyco-core Research (iGCORE), Tokai National Higher Education and Research System
  • 2019/10 - 現在 Artificial Intelligence Advanced Research Center, Gifu University
  • 2018/04 - 現在 Gu Composites Center, Gifu University
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Committee career (8)：
  • 2023/07 - 現在 Nucleic Acids Therapeutics Society of Japan Councilor
  • 2017/11 - 現在 日本プロセス化学会 東海地区フォーラム幹事
  • 2022/07 - 2023/07 Nucleic Acids Therapeutics Society of Japan Natsj8, Symposium for Young Researchers, organizer
  • 2022/07 - 2023/07 Nucleic Acids Therapeutics Society of Japan 8th Annual Meeting of the Nucleic Acids Therapeutics Society of Japan, organizing committee member
  • 2020/02 - 2022/01 日本化学会 CSJ化学フェスタ実行委員
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Awards (2)：
  • 2013 - Ajinomoto Award in Synthetic Organic Chemistry, Japan
  • 2011 - Incentive Award for Young Scientist, Tokai branch of The Society of Synthetic Organic Chemistry, Japan
Association Membership(s) (9)：
The Society of Silicon ChemistryJAPAN ,  The Japanese Peptide Society ,  The Society of Synthetic Organic Chemistry, Japan ,  The Chemical Society of Japan ,  THE JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH ,  Japan Society of Nucleic Acids Chemistry ,  日本核酸医薬学会 ,  American Chemical Society ,  The Japan Society for Process Chemisry
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