Rchr
J-GLOBAL ID：200901049472240215
Update date: Sep. 20, 2024
Osumi Kenji
Osumi Kenji
Affiliation and department：
Job title：
Researcher
Research field (1)：
Synthetic organic chemistry
Research keywords (4)：
transglycosylation
, 合成
, オリゴ糖
, antibody-drug conjugates
Research theme for competitive and other funds (3)：
- 2012 - 2016 Development of anti-saccharide antibody screening system using glycosylated silsesquioxane probe.
- 2011 - 2013 筋ジストロフィーの治療法開発を目指した発症メカニズムの解明研究
- 2010 - 2012 Studies on the function utilization of sialic acid-containing Oligosaccharides peptide
Papers (29)：
-
Shou Takashima, Masaki Kurogochi, Wataru Tsukimura, Masako Mori, Kenji Osumi, Shu-Ichi Sugawara, Junko Amano, Mamoru Mizuno, Yoshio Takada, Akio Matsuda. Preparation and biological activities of anti-HER2 monoclonal antibodies with multi-branched complex-type N-glycans. Glycobiology. 2021
-
Shou Takashima, Masaki Kurogochi, Kenji Osumi, Shu-Ichi Sugawara, Mamoru Mizuno, Yoshio Takada, Junko Amano, Akio Matsuda. Novel endo-β-N-acetylglucosaminidases from Tannerella species hydrolyze multibranched complex-type N-glycans with different specificities. Glycobiology. 2020. 30. 11. 923-934
-
Michihiko Aoyama, Noritaka Hashii, Wataru Tsukimura, Kenji Osumi, Akira Harazono, Minoru Tada, Masato Kiyoshi, Akio Matsuda, Akiko Ishii-Watabe. Effects of terminal galactose residues in mannose α1-6 arm of Fc-glycan on the effector functions of therapeutic monoclonal antibodies. mAbs. 2019. 11. 5. 826-836
-
Rieko Imae, Hiroshi Manya, Hiroki Tsumoto, Kenji Osumi, Tomohiro Tanaka, Mamoru Mizuno, Motoi Kanagawa, Kazuhiro Kobayashi, Tatsushi Toda, Tamao Endo. CDP-glycerol inhibits the synthesis of the functional O-mannosyl glycan of α-dystroglycan. The Journal of biological chemistry. 2018. 293. 31. 12186-12198
-
Wataru Tsukimura, Masaki Kurogochi, Masako Mori, Kenji Osumi, Akio Matsuda, Kaoru Takegawa, Kiyoshi Furukawa, Takashi Shirai. Preparation and biological activities of anti-HER2 monoclonal antibodies with fully core-fucosylated homogeneous bi-antennary complex-type glycans. Bioscience, Biotechnology and Biochemistry. 2017. 81. 12. 2353-2359
ｍore...
MISC (31)：
-
水野真盛, 後藤浩太朗, 大隅賢二, 森昌子, 月村亘, 筒井正斗, 弘瀬友理子, 高田美生, 杉智和. 抗体中の糖鎖を薬物搭載部位とするADCの足場剤開発. 日本抗体学会学術大会プログラム・抄録集(Web). 2022. 1st
-
後藤浩太朗, 森昌子, 月村亘, 大隅賢二, 弘瀬友理子, 筒井正斗, 黒河内政樹, 石田秀樹, 松崎祐二, 高田美生, et al. One-pot synthesis of antibody-drug conjugate (ADC) precursor with Azido-PEGylated oxazoline. 日本薬学会年会要旨集(Web). 2022. 142nd
-
筒井正斗, 後藤浩太朗, 大隅賢二, 浜元健太, 弘瀬友理子, 高島晶, 水野真盛. Synthesis of glycan derivatives for site-specific antibody-drug conjugates and evaluation of their transfer activity. 日本糖質学会年会要旨集. 2021. 40th
-
水野真盛, 後藤浩太朗, 森昌子, 月村亘, 大隅賢二, 弘瀬友理子, 筒井正斗, 黒河内政樹, 石田秀樹, 松崎祐二, et al. Synthesis of antibody-drug conjugate (ADC) precursor using PEGylated disaccharide oxazoline derivative. 日本糖質学会年会要旨集. 2021. 40th
-
高島晶, 大隅賢二, 黒河内政樹, 水野真盛, 高田美生, 松田昭生. Transglycosylation of G3a type tri-antennary complex type N-glycan to antibody by glycosynthases. 日本農芸化学会大会講演要旨集(Web). 2020. 2020
ｍore...
Patents (21)：
-
7糖オリゴ糖の製造方法
-
糖アミノ酸誘導体または糖ペプチド誘導体の製造方法
-
糖ペプチド誘導体及びその製造方法
-
糖ペプチド結合ポリマー
-
血管内皮細胞の管腔形成抑制剤
ｍore...
Professional career (2)：
- (BLANK) (Meiji University)
- Doctor (Tokyo Institute of Technology)
Association Membership(s) (1)：
Return to Previous Page
