Kobayashi Hiroshi

2020 - 2023 Verification of the safety and effectiveness of a test for predicting malignant transformation of endometriosis

2020 - 2023 Establishment of a qualitative imaging method to non-invasively predict the severity of adenomyosis

2020 - 2023 HNF1β-USP28-CLASPIN-Chk1阻害に対する合成致死候補の検索

2020 - 2023 好中球増多を伴う子宮悪性腫瘍における癌幹細胞による好中球細胞外トラップ誘導機構

2019 - 2022 Search for synthetic lethal candidates for PIK3CA mutations

2019 - 2022 Involvement of Imprinting genes in Hypertensive Disorders of Pregnancy

2019 - 2022 Establishment of a novel test method for early prediction of malignant transformation of endometriosis using MR spectroscopy.

2017 - 2022 Development of a care programe for pregnant women living far from delivery facilities and verification of the effectiveness of the electronic mother and child handbook.

2018 - 2021 Novel therapeutic approach for endometriosis targeting variant isoforms of CD44

2018 - 2021 Development of a novel treatment for refractory ovarian clear cell carcinoma by targeting cell cycle monitoring mechanism

2018 - 2021 The carcinogenesis of ovarian endometrioma due to redox environmentt

2017 - 2020 Early detection method for clear cell carcinoma of the ovary by combining HE4 and TFPI2

2017 - 2020 子宮内膜症の微小環境における酸化還元反応のバランス変化に基づく発癌仮説の構築

2017 - 2020 チェックポイント機構をターゲットとした難治卵巣明細胞癌の新規治療法の開発

2017 - 2020 Translational research focused on the abnormal blood coagulation system in patients with clear cell carcinoma of ovary

2016 - 2019 Predictive diagnosis of endometriosis-associated malignant transformation by iron concentration measurement using magnetic resonance spectroscopic imaging.

2016 - 2019 A promising ovarian cancer therapy in the application of a Band-Aid type peptide-based treatment

2016 - 2019 Establishment of management criteria for postoperative venous thromboembolism that can be carried out simply and safely

2016 - 2019 Diagnosis and treatment of the minimally invasive laser therapy using composite-type optical fiber for endometrial lesions

2015 - 2018 Involvemnt of adipose tissue in hypertensive disorders of pregnancy

2015 - 2017 Production of synthetic peptides with antimetastatic activity through inhibition of uPAR function

2014 - 2017 The CD44v9-targeted therapy for intractable ovarian cancer

2014 - 2017 Eucidate using SCC how effect when amniotic fluid entered into maternal circulation

2014 - 2017 Pathogenesis of endometriosis and its malignant transformation.

2014 - 2017 The serine protease (TFPI2) is a useful biomarker for ovarian clear cell carcinoma

2013 - 2016 Elucidation of the new treatment by modification of cell cycle checkpoint mechanism for ovarian clear cell adenocarcinoma

2013 - 2016 Development of Molecular Targeted Anti-tumor Drugs for Ovarian Cancer Using Soy Protein Peptide Which Can Be Administered Orally

2013 - 2015 Diagnosis of amniotic fluid embolism by serum SCC

2012 - 2015 Development of a new marker to predict pregnancy-Induced hypertension in the cervical mucus

2012 - 2015 development by overcoming resistance to anticancer drugs against ovarian clear cell adenocarcinoma

2012 - 2015 Investigation of the role of Hepatocyte Nuclear Factor-1 beta in the cell cycle checkpoint of clear cell adenocarcinoma in the ovary

2011 - 2014 Endometriosis-associated ovarian carcinogenesis induced by iron-dependent oxidative stress

2011 - 2013 elucidate a role of the meconium in the fatal cause of the amniotic fluid embolism

2011 - 2013 investigation of molecular targeted therapy in gynecologic malignancies

2012 - 2012 Investigation into multiple pathways involved in the malignant transformation of endometriosis

2010 - 2012 Oxidative stress in the pathogenesis of clear cell carcinoma of the ovary.

2010 - 2012 Invention of prophylactic medicine for premature birth made from soybean.

2008 - 2011 Investigation into malignant transformation of endometriosis. prospective cohort study and molecular biology research

2009 - 2010 マイクロアレイ・プロテオミクス技術を駆使した卵巣癌の予後規定因子の網羅的探索

2008 - 2010 The Role of Hepatocyte Nuclear Factor-1Beta in the Pathogenesis of Endometriosi-Associated Ovarian Cancer

2008 - 2010 A made-to-order ovarian cancer treatment strategy using thalidomide as the newly molecular target antineoplastic drug

2008 - 2010 Investigate the new serum markers and create clinical guidelines for the diagnosis of amniotic fluid embolism

2008 - 2009 大豆蛋白成分の網羅的解析による早産予防効果の実証実験

2007 - 2008 Alteration of Adiponectin and related cytokines in implantation disorder for complicated pregnancy

2007 - 2008 網羅的シグナローム解析に基づくE-cellを用いた癌転移シミュレーションの構築

2007 - 2008 Antiinflammatory action of bikunin produced by human endometrium

2007 - 2008 Construction of unification database for pharmacodynamics of medicine in pregnant/puerperal women

2006 - 2007 Production and Treatment Strategies of Molecular Targeting Anti-Metastatic Agent

2002 - 2004 Gene Therapy for Ovarian Cancer by Bikunin

2001 - 2003 A basic study on gene therapy for ovarian cancer to inhibition peritoneal dissemination

2001 - 2003 Study for clinical use of anti-inetastatic agent, bikunin

2000 - 2003 The elucidation of amniotic fluid embolism

2001 - 2001 分子疫学的解析による遺伝性子宮内膜癌の病態解明

1999 - 2001 A basic study of gene therapy for ovarian cancer : inhibition of angiogenesis and metastasis/invasion

1999 - 2001 Anti-metastatic gene therapy by human amniotic fluid-derived bikunin

1995 - 1997 Production and characterization of newly developed anti-metastatic agents

1994 - 1995 Study on the mechanism of extracellular matrix degradation induced by tumor cell associated fibrinolytic enzyme

1992 - 1995 ムチン母核構造を認識する抗体を用いた羊水塞栓症の新しい診断

婦人科がん転移抑制

癌転移抑制剤の開発をその臨床応用

羊水寒栓症の血清診断

卵巣癌に対する新規腫瘍マーカーの開発

癌転移抑制物質の開発

Serological diagnosis for amniotic fluid embolism

Development of novel tumor markers for ovarian cancer

Agents that inhibit tumor cell invasion and metastasis