Rchr
J-GLOBAL ID：200901049597997873   Update date: Feb. 14, 2024

Hashimoto Yuichi

ハシモト ユウイチ | Hashimoto Yuichi
Affiliation and department：
The University of Tokyo Institute of Molecular and Cellular Biosciences, Department of Structural Biology, Laboratory of Bioorganic Chemistry

About The University of Tokyo Institute of Molecular and Cellular Biosciences, Department of Structural Biology, Laboratory of Bioorganic Chemistry


Job title： Professor
Homepage URL  (1)： http://www.iam.u-tokyo.ac.jp/chem/index.html
Research field  (1)： Pharmaceuticals - chemistry and drug development
Research keywords  (2)： 生物有機化学 ,  Bioorganic Chemistry
Research theme for competitive and other funds  (53)：
  • 2017 - 2020 Structural and functional development studies of ligands for disease progression factors
  • 2016 - 2019 Development of silicon-containing units as expanded bioisosters
  • 2014 - 2017 Polypharmacology based on dynamism of the target protein
  • 2013 - 2015 Chemical biology of trafficking regulation of membrane cholesterol transporter protein
  • 2010 - 2014 Chemical control of protein dramatype
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Papers (11)：
  • Keigo Hirai, Hiroko Yamashita, Shusuke Tomoshige, Yugo Mishima, Tatsuya Niwa, Kenji Ohgane, Mayumi Ishii, Kayoko Kanamitsu, Yui Ikemi, Shinsaku Nakagawa, et al. Conversion of a PROTAC Mutant Huntingtin Degrader into Small-Molecule Hydrophobic Tags Focusing on Drug-like Properties. ACS Medicinal Chemistry Letters. 2022. 13. 3. 396-402
  • Yuki Ichikawa, Michiaki Hiramatsu, Yusuke Mita, Makoto Makishima, Yotaro Matsumoto, Yui Masumoto, Atsuya Muranaka, Masanobu Uchiyama, Yuichi Hashimoto, Minoru Ishikawa. meta-Non-flat substituents: a novel molecular design to improve aqueous solubility in small molecule drug discovery. Organic & Biomolecular Chemistry. 2021. 19. 2. 446-456
  • Ryuta Shioi, Fumika Karaki, Hiromasa Yoshioka, Tomomi Noguchi-Yachide, Minoru Ishikawa, Kosuke Dodo, Yuichi Hashimoto, Mikiko Sodeoka, Kenji Ohgane. Image-based screen capturing misfolding status of Niemann-Pick type C1 identifies potential candidates for chaperone drugs. PLOS ONE. 2020. 15. 12. e0243746-e0243746
  • Shinpei Murasawa, Katsuya Iuchi, Shinichi Sato, Tomomi Noguchi-Yachide, Mikiko Sodeoka, Tsutomu Yokomatsu, Kosuke Dodo, Yuichi Hashimoto, Hiroshi Aoyama. Small-molecular inhibitors of Ca2+-induced mitochondrial permeability transition (MPT) derived from muscle relaxant dantrolene. Bioorganic and Medicinal Chemistry. 2012. 20. 21. 6384-6393
  • Hiroshi Aoyama, Kumiko Sako, Shinichi Sato, Masahiko Nakamura, Hiroyuki Miyachi, Yukinori Goto, Mika Okamoto, Masanori Baba, Yuichi Hashimoto. Polymethylated γ-carbolines with potent anti-bovine viral diarrhea virus (BVDV) activity. Heterocycles. 2009. 77. 2. 779-785
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MISC (11)：
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Patents (7)：
  • Benzodiazepine derwatives as preventives/remedies for diabetes
  • Medical composition
  • サイトカイニン結合蛋白質
  • 医薬組成物
  • 抗アンドロゲン剤
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Books (2)：
  • 生体有機化学
    東京化学同人 2012
  • ベーシック薬学教科書シリーズ6「創薬科学・医薬化学」第6章「創薬研究の基礎知識ーーー標的となる生体分子」
    化学同人 2007
Education (4)：
  • - 1982 The University of Tokyo
  • - 1982 The University of Tokyo Graduate School, Division of Pharmaceutical Sciences
  • - 1977 The University of Tokyo Faculty of Pharmaceutical Sciences
  • - 1977 The University of Tokyo Faculty of Pharmaceutical Science
Professional career (2)：
  • Pharmaceutical Doctor
  • 薬学修士 (東京大学)
Work history (10)：
  • 2020/06 - Emeritus Professor
  • 2020/03 - 定年退職
  • 1997 - The University of Tokyo Institute of Molecular and Cellular Biosciences
  • 1997 - professor, Institute of Molecular and Cellular Biosciences,
  • 1989 - 東京大学応用微生物研究所助教授
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Committee career (2)：
  • 2007 - 日本薬学会医薬化学部会 役員
  • 2000 - 日本ビタミン学会 理事
Awards (4)：
  • 2006 - 日本薬学会創薬科学賞
  • 1986 日本薬学会奨励賞
  • Pharmaceutical Society of Japan
  • 1986 Promoting Award for Pharmaceutical Sciences,
Association Membership(s) (8)：
日本ビタミン学会 ,  米国化学会 ,  日本薬学会 ,  日本癌学会 ,  The Vitamin Society of Japan ,  The Pharmaceutical Society of Japan ,  Japanese Cancer Association ,  American Chemical Society
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