Nagano Hiroaki

2021 - 2024 Identification of tumor-specific antigens to construct the novel combination immunotherapy

2021 - 2024 がん発症・進展過程におけるYAPの活性化の機械的制御機構の解明

2019 - 2021 Creation of lyph node organoids enabling mechanical control of immunity

2018 - 2021 Deployment to personalized medicine targeting pancreatic cancer stem cells and tumor microenvironment

2018 - 2021 Novel immunotherapy for pancreatic cancer by the multi-HLA binding peptides derived from cancer stemness molecules.

2015 - 2020 Achievement of highly accurate diagnosis of early pancreatic cancer in Japanese patients through a comprehensive/integrated approach

2015 - 2018 The significance of c-myc expression in pancreatic cancer

2015 - 2018 Research on personalized medicine against treatment-resistant liver cancer from the viewpoint of epithelial-Mesenchymal Transition and hierarchical replication ability

2014 - 2017 Function analysis of exosome derived from hepatocellular carcinoma cells under hypoxia for tumor angiogenesis, invasion and metastasis

2014 - 2017 New construction of innovative drug discovery foundation technology for refractory gastrointestinal cancer targeting cancer metabolomics

2014 - 2016 Development of a therapeutic option for anti-cancer drug-resistant malignancies via reprograming method using microRNAs.

2013 - 2016 Investigation of microRNA interaction between pancreatic cancer cells and the stromal cells aiming to overcome the resistance to chemotherapeutic drugs.

2013 - 2016 Comprehensive characterization of next generation strategy to improve clinical islet transplantation

2013 - 2015 Identification of novel inducing factors pancreatic beta cells by iPS modified technology

2013 - 2015 肝移植における抗ドナー特異抗体産生意義の解明と個別化免疫療法の探求

2012 - 2015 Change of cancer and pericancerous tissue induced by inflammation, IL-6/TGF-beta crosstalk, in biliary tract cancers.

2012 - 2015 Evaluation of the mechanism of liver regeneration focused on intracellular signal transduction and Non-coding RNA expression

2012 - 2014 Therapeutic applications and effects on liver cancer cells by reprogramming related miRNA

2010 - 2012 Correlation between expression of exocrine progenitor genes and cancer stem cells in pancreatic cancer.

2010 - 2012 Involvement of microRNA in the sensitivity prediction ofpreoperative chemoradiotherapy in pancreatic cancer

2009 - 2011 Establishment of non-invasive diagnostic methods for allograft dysfunction and real-time monitoring of immunological status in liver transplant

2009 - 2011 The expandion in application of novel treatment through the liver specific siginaling pathway for the intractable and advanced hepatocellular carcinoma

2009 - 2010 肝癌症例末梢血中の転移形成能力を有する癌細胞の検出

2008 - 2010 肝胆膵領域の新規バイオマーカーの探索

2008 - 2009 大腸上皮幹細胞の加齢による変化と発癌への関与

2007 - 2008 超弾性を有する曲がり多重穿刺針及びその制御に関する研究

2007 - 2008 Diagnostic system for acute cellular rejection in livertransplantation using protemomic analysis of bile

2007 - 2008 Development of potential new treatment for theHCC targeting specificsignal and molecules

2005 - 2006 Identifying novel molecular markers of human hepatocellular carcinoma

2005 - 2006 The development of novel treatment through the hepatocellular carcinoma (HCC) specific siginaling pathway and molecular based gene expression profiling for advanced HCC

2004 - 2005 The establishment of novel multimodal treatment through the hepatoma specific siginaling pathway for the intractable and advanced hepatocellular carcinoma

2004 - 2005 Treatment of hepatocellular carcinoma after liver transplantation by graft versus tumor effcect using bone marrow co-transplantation

2003 - 2004 Suppression of hepatic ischemia/reperfusion injury by early expression of protective protein

2003 - 2004 The establishment of immuno-chemotherapy through the IFN-IFNAR (IFN-α receptor) signaling pathway for the intractable and advanced hepatocellular carcinoma

2002 - 2003 The treatment for the intractable and advanced targeffing the angiogenesis and immuno-reaction

2002 - 2003 The molecular-based prediction of the allograft rejection using the gene expression profiling study

2002 - 2003 Clinical and basic research for application of liver transplantation for the treatment of hepatocellular carcinoma

2001 - 2002 Suppression of hepatic ischemia/reperfusion injury using RNA

2001 - 2002 Development of a new multidisciplinary therapy for the intractable, advanced hepatocellular carcinoma, targeting the intracellular signaling molecules.

2000 - 2001 Tolerance induction using unique immune response in the liver

1998 - 2000 Establishment of Molecular Based Surgery for Cancer Control

1998 - 1999 移植後慢性拒絶反応の病態の解析について

1998 - 1999 Study for Molecular Mechanisms of Endothelial and Methotelial Cell Retraction during Cancer Cell Invasion

1997 - 1998 Anti-allo immune response in the liver after inoculation of allogeneic antigen

慢性拒絶反応の解析

移植免疫に関する研究(寛容誘導)

肝癌の外科的治療に関する研究

Investigation of chronic rejection

Study of Transplantation Immunology : Tolerance Induction

Study of Surgical Treatment for Hepatic Cancer