- 2023 - 2026 腫瘍と宿主の動的平衡状態の解明による膵癌個別化治療の開発
- 2023 - 2026 乳癌患者由来オルガノイドを用いた抗癌剤耐性機構の解明
- 2022 - 2025 肝癌における癌幹細胞性獲得と免疫監視逃避における細胞外シグナルの解析
- 2022 - 2024 A mini-organ culture system with cancer immune microenvironment recapitulating in vivo
- 2021 - 2024 症例登録事業の根幹をなす精度検証とその向上に資する支援のあり方についての研究
- 2021 - 2024 Identification of tumor-specific antigens to construct the novel combination immunotherapy
- 2021 - 2024 がん発症・進展過程におけるYAPの活性化の機械的制御機構の解明
- 2019 - 2021 Creation of lyph node organoids enabling mechanical control of immunity
- 2018 - 2021 Deployment to personalized medicine targeting pancreatic cancer stem cells and tumor microenvironment
- 2018 - 2021 Novel immunotherapy for pancreatic cancer by the multi-HLA binding peptides derived from cancer stemness molecules.
- 2015 - 2020 Achievement of highly accurate diagnosis of early pancreatic cancer in Japanese patients through a comprehensive/integrated approach
- 2015 - 2018 The significance of c-myc expression in pancreatic cancer
- 2015 - 2018 Research on personalized medicine against treatment-resistant liver cancer from the viewpoint of epithelial-Mesenchymal Transition and hierarchical replication ability
- 2014 - 2017 Function analysis of exosome derived from hepatocellular carcinoma cells under hypoxia for tumor angiogenesis, invasion and metastasis
- 2014 - 2017 New construction of innovative drug discovery foundation technology for refractory gastrointestinal cancer targeting cancer metabolomics
- 2014 - 2016 Development of a therapeutic option for anti-cancer drug-resistant malignancies via reprograming method using microRNAs.
- 2013 - 2016 Investigation of microRNA interaction between pancreatic cancer cells and the stromal cells aiming to overcome the resistance to chemotherapeutic drugs.
- 2013 - 2016 Comprehensive characterization of next generation strategy to improve clinical islet transplantation
- 2013 - 2015 Identification of novel inducing factors pancreatic beta cells by iPS modified technology
- 2013 - 2015 肝移植における抗ドナー特異抗体産生意義の解明と個別化免疫療法の探求
- 2012 - 2015 Change of cancer and pericancerous tissue induced by inflammation, IL-6/TGF-beta crosstalk, in biliary tract cancers.
- 2012 - 2015 Evaluation of the mechanism of liver regeneration focused on intracellular signal transduction and Non-coding RNA expression
- 2012 - 2014 Therapeutic applications and effects on liver cancer cells by reprogramming related miRNA
- 2010 - 2012 Correlation between expression of exocrine progenitor genes and cancer stem cells in pancreatic cancer.
- 2010 - 2012 Involvement of microRNA in the sensitivity prediction ofpreoperative chemoradiotherapy in pancreatic cancer
- 2009 - 2011 Establishment of non-invasive diagnostic methods for allograft dysfunction and real-time monitoring of immunological status in liver transplant
- 2009 - 2011 The expandion in application of novel treatment through the liver specific siginaling pathway for the intractable and advanced hepatocellular carcinoma
- 2009 - 2010 肝癌症例末梢血中の転移形成能力を有する癌細胞の検出
- 2008 - 2010 肝胆膵領域の新規バイオマーカーの探索
- 2008 - 2009 大腸上皮幹細胞の加齢による変化と発癌への関与
- 2007 - 2008 超弾性を有する曲がり多重穿刺針及びその制御に関する研究
- 2007 - 2008 Diagnostic system for acute cellular rejection in livertransplantation using protemomic analysis of bile
- 2007 - 2008 Development of potential new treatment for theHCC targeting specificsignal and molecules
- 2005 - 2006 Identifying novel molecular markers of human hepatocellular carcinoma
- 2005 - 2006 The development of novel treatment through the hepatocellular carcinoma (HCC) specific siginaling pathway and molecular based gene expression profiling for advanced HCC
- 2004 - 2005 The establishment of novel multimodal treatment through the hepatoma specific siginaling pathway for the intractable and advanced hepatocellular carcinoma
- 2004 - 2005 Treatment of hepatocellular carcinoma after liver transplantation by graft versus tumor effcect using bone marrow co-transplantation
- 2003 - 2004 Suppression of hepatic ischemia/reperfusion injury by early expression of protective protein
- 2003 - 2004 The establishment of immuno-chemotherapy through the IFN-IFNAR (IFN-α receptor) signaling pathway for the intractable and advanced hepatocellular carcinoma
- 2002 - 2003 The treatment for the intractable and advanced targeffing the angiogenesis and immuno-reaction
- 2002 - 2003 The molecular-based prediction of the allograft rejection using the gene expression profiling study
- 2002 - 2003 Clinical and basic research for application of liver transplantation for the treatment of hepatocellular carcinoma
- 2001 - 2002 Suppression of hepatic ischemia/reperfusion injury using RNA
- 2001 - 2002 Development of a new multidisciplinary therapy for the intractable, advanced hepatocellular carcinoma, targeting the intracellular signaling molecules.
- 2000 - 2001 Tolerance induction using unique immune response in the liver
- 1998 - 2000 Establishment of Molecular Based Surgery for Cancer Control
- 1998 - 1999 移植後慢性拒絶反応の病態の解析について
- 1998 - 1999 Study for Molecular Mechanisms of Endothelial and Methotelial Cell Retraction during Cancer Cell Invasion
- 1997 - 1998 Anti-allo immune response in the liver after inoculation of allogeneic antigen
- 慢性拒絶反応の解析
- 移植免疫に関する研究(寛容誘導)
- 肝癌の外科的治療に関する研究
- Investigation of chronic rejection
- Study of Transplantation Immunology : Tolerance Induction
- Study of Surgical Treatment for Hepatic Cancer
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