Research field (2)：
Pharmacology
, Pharmaceuticals - health and biochemistry
Research keywords (2)：
Pharmacokinetics
, Toxicology
Research theme for competitive and other funds (29)：
2026 - 2029 担がん免疫環境を利用した特異体質性薬物性肝障害モデル構築
2023 - 2026 HLAと薬物の相互作用様式の違いが持つ免疫学的・毒性学的意義の解明
2021 - 2026 医療系学部・大学院の全員留学による学びの包括的評価に関する実証研究
2021 - 2025 Mechanistic research on the onset of drug toxicity reflecting interindividual differences to avoid serious adverse events
2021 - 2025 Scientific research of the onset mechanism of drug-induced idiosyncratic toxicity to avoid serious side effects
2019 - 2023 HLA多型の構造的特徴に基づく皮膚特異的な過敏症リスク薬物の評価系構築
2018 - 2019 Construction of an in vivo model for prediction of fulminant type DILI in preclinical/clinical
2015 - 2019 Elucidation of the pathogenesis of idiosyncratic drug-induced liver injury using HLA-transfected mice for establishment of preclinical prediction method
2015 - 2017 Elucidation of the onset mechanism of abacavir-induced severe skin reaction using humanized model animal
2014 - 2017 Fundamental study for integrated understanding of the mechanism of DILI and its prediction
2012 - 2016 Basis study for the prediction of fatal DILI risk based on MHC expression in the liver
2013 - 2015 Construction of improved lymphocyte transformation test based on the onset and aggravation mechanism of drug-induced liver injury
2010 - 2012 Research on Drug-Induced Liver Injury Associated with MetabolicActivation by CYP
2010 - 2011 Analysis of the molecular mechanism of hepatic GSH decrease during drug induced liver injury.
2005 - 2009 Analysis of the function and regulatory mechanism of drug transportsome
2007 - 2008 Establishment of quantitative prediction method for the individual variabilities in hematologic toxicity of anti-cancer agents
2006 - 2007 Investigation on the molecular mechanism of NPC1L1-mediated cholesterol uptake
2006 - 2007 Systematic analysis of intestinal absorption process considering drug transportation across membranes
2005 - 2006 Investigation on the transport mechanism of bile lipids
2004 - 2005 MRP2 mediated defense against oxidative stress in liver
2004 - 2005 Role of Mitochondria as Signal Sensors in Drug-Induced Liver Injury
2002 - 2003 Involvement of cytokines in drug-induced liver injury
2001 - 2002 有機アニオン性化合物の胆汁排泄機構
2001 - 2002 Evaluation of drug-induced hepatotoxicity by chemiluminescence and the role of MRP2 in the hepatotoxicity
2001 - 2002 小腸上皮細胞の分化過程における異物排泄ポンプの生理的意義
2001 - 2002 細胞質蛋白による異物排出トランスポーター局在調節機構の解析
1998 - 2002 ABC蛋白スーパーファミリーによる異物排出機構の解析
2000 - Biliary excretion mechanism of organic anions
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Papers (135)：
Akinori Takemura, Shunya Naito, Yuichiro Higuchi, Shotaro Uehara, Nao Yoneda, Hiroshi Suemizu, Kousei Ito. Application of HepaSH cells for predicting cholestatic drug-induced liver injury via bile acid-dependent toxicity assay. Drug Metabolism and Pharmacokinetics. 2026
Shigeki Aoki, Akira Kazaoka, Kousei Ito. Recent Insights into HLA-dependent Idiosyncratic Liver Injury. YAKUGAKU ZASSHI. 2026. 146. 2. 115-122
Zhiheng Zhang, Liye Fang, Hiroki Furukawa, Andy Huang, Joshua Kranrod, John M. Seubert, Kousei Ito, Shigeki Aoki. Maladaptive role of peridroplet mitochondria during lipophagy disruption in pancreatic cancer. Biochemical and Biophysical Research Communications. 2025. 782. 152609-152609
TAKEMURA Akinori, IKEYAMA Yugo, FUJITA Atsuya, ITO Kousei. Involvement of platelet activation by mitochondrial permeability transition in acetaminophen-induced liver injury. Annual Meeting of the Japanese Society of Toxicology. 2025. 52.1. P-5E
Akinori Takemura, Shotaro Suminoe, Tomoya Hirai, Keito Nakasone, Kotaro Hayasaki, Binbin Song, Kousei Ito. Alteration of bile acid composition is a possible risk factor for antibiotics-induced liver injury. The Journal of toxicological sciences. 2025. 50. 8. 379-386
SHUN Shiyori, SHUN Shiyori, 薄田健史, 白柳智弘, 青木重樹, 伊藤晃成, 早川芳弘. Development of a novel cancer immunotherapy based on tumor immunogenicity improvement by carbamazepine and HLA-B*15:02 interaction. 日本薬学会年会要旨集(Web). 2024. 144th
Understanding the Unpredictable: Mechanistic Insights into Idiosyncratic DILI for Informing Risk Prediction
(2025)
HLA-dependent drug hypersensitivity: latest findings from our animal models
(7th annual conference of the Society for the Study of Xenobiotics (SSX-India) 2024)
The Japanese Society for the Research of Hepatic Cells
, 日本動物実験代替法学会
, The Japanese Society of Toxicology
, The Japanese Society for the Study of Xenobiotics
, The Pharmaceutical Society of Japan
, トランスポーター研究会
, 胆汁酸研究会
