HORIUCHI Hiroaki

ホリウチヒロアキ | HORIUCHI Hiroaki

Affiliation and department：
Homepage URL (1)： https://www2.kpu.ac.jp/photochem/

Research field (1)： Pharmaceuticals - analytical and physicochemistry

Research keywords (6)： porphyrin , singlet oxygen , photosensitizer , Photodynamic therapy , photochemistry , physical chemistry

Research theme for competitive and other funds (18)：

2023 - 2026 糖脂質SQAPによる固形腫瘍組織内酸素分圧上昇機序の解明と放射線治療への展開
2022 - 2025 Crystallization of difficult-to-crystallize substances using the concentration effect of surface plasmon resonance and creation of separation and purification technology
2020 - 2023 Screening for interacting proteins with glycolipid SQAP and application to radiotherapy
2019 - 2022 プラズモン共鳴による光濃縮効果を用いた膜タンパクの結晶化
2019 - 2022 Developments of triple pH-activatable photosensitizer for highly selective photodynamic therapy of cancer

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Papers (67)：

T. Yasue, M. Murakami, Y. Takasuka, T. Sato, F. Saito, H. Horiuchi, T. Okutsu. Crystallization of Lysozyme Induced by Gap-Mode Surface Plasmon Resonance of Gold Nanocolloids. J. Phys. Chem. C. 2024. 128. 9602-9612
H. Horiuchi, K. Nishikawa, N. Ishii, K. Kano, S. Shinada, N. Osawa, A. Horikoshi, T. Yoshihara, F. Sugawara, K. Sakaguchi, et al. A silyl porphyrin derivative conjugated with 6-deoxy-6-sulfo-α-D-glucopyranose functions as an efficient photosensitizer for photodynamic therapy. Photodiagnosis Photodyn. Ther. 2024. 45. 103898-103904
Hiroaki HORIUCHI. Development of novel photosensitizers for highly tumor-selective photodynamic therapy and diagnosis. The Journal of Japan Society for Laser Surgery and Medicine. 2022. in press
Masahiko Oshige, Koki Kano, Shunsuke Shinada, Akifumi Kawaguchi, Takato Uchida, Nozomi Ishii, Hiroaki Horiuchi, Fumio Sugawara, Kengo Sakaguchi, Ichiro Matsuo, et al. Synthesis of 3-octadecanoxypropyl 6-deoxy-6-sulfo-α-d-glucopyranoside (ODSG) as a lipase-resistant SQAP derivative. Bioorganic & Medicinal Chemistry Letters. 2021. 52. 128391-128391
Hiroaki Horiuchi. Development of Activatable Photosensitizer for Photodynamic Therapy of Cancer. The Journal of Japan Society for Laser Surgery and Medicine. 2021. 41. 4. 363-369

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MISC (167)：

腰越依紗那, 堀内宏明, 奥津哲夫. In-situ observation of protein crystal nucleation. 結晶成長国内会議予稿集(CD-ROM). 2022. 51st
秋葉菜々子, 堀内宏明, 奥津哲夫. Crystallization Induced of Low-molecular weight Organic Compounds in vivo using Gold Thin Films. 結晶成長国内会議予稿集(CD-ROM). 2022. 51st
桐生みか, 堀内宏明, 奥津哲夫. Phenomenon of spatially separated crystallization from a mixture solution. 応用物理学会秋季学術講演会講演予稿集(CD-ROM). 2022. 83rd
高須賀友香, 堀内宏明, 奥津哲夫. Effect of charge on adsorption and crystallization of proteins to gold nanoparticles. 応用物理学会秋季学術講演会講演予稿集(CD-ROM). 2022. 83rd
齋藤文恵, 佐藤友彦, 堀内宏明, 奥津哲夫. Effect of Heat on Light Induced Crystallization of Proteins. 応用物理学会秋季学術講演会講演予稿集(CD-ROM). 2022. 83rd

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Patents (8)：

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Books (8)：

Advances in Organic Crystal Chemistry: Comprehensive Reviews 2025
Springer 2025
Spectroscopic Tools for the Diagnosis and Treatment of Cancer ーA Symposium Bookin PACIFICHEM 2015
Sankeisha 2017 ISBN:9784864877039
炭素とケイ素の元素科学
群馬大学 2014
光化学の事典
朝倉書店 2014
最強エレメントケイ素の不思議
上毛新聞社 2012

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Lectures and oral presentations (387)：

Triple pH-activatable photosensitizer for near-infrared photodynamic theranostics
(PacifiChem 2021 2021)
ギャップ構造をもつ金コロイドフィルムの表面プラズモン共鳴を利用したタンパク質の結晶化
(2021年日本化学会関東支部群馬地区研究交流発表会 2021)
光線力学療法・診断への応用を目指したトリプルpH応答性光増感剤への反応性置換基の導入
(2021年日本化学会関東支部群馬地区研究交流発表会 2021)
タンパク質の結晶核形成のその場観察
(2021年日本化学会関東支部群馬地区研究交流発表会 2021)
タンパク質の金ナノ粒子への吸着および結晶化における電荷の影響
(2021年日本化学会関東支部群馬地区研究交流発表会 2021)

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Education (3)：

Professional career (1)：

Work history (7)：

2024/04 - 現在 Kyoto Prefectural University Graduate School of Life and Environmental Sciences (MC and DC) Professor
2013/04 - 2024/03 Gunma University Graduate School of Science and Technology Associate professor
2007/04 - 2013/03 Gunma University Assistant professor
2001/06 - 2007/03 Gunma University Department of Chemistry Research assistant
2001/04 - 2001/05 National Institute of Advanced Industrial Science and Technology

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Committee career (3)：

Awards (4)：

Association Membership(s) (4)：

日本光医学・光生物学会 , 光化学協会 , 日本化学会 , 日本光線力学学会

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