Rchr
J-GLOBAL ID:200901050496560286
Update date: Aug. 16, 2024
Hiwasa Takaki
ヒワサ タカキ | Hiwasa Takaki
Affiliation and department:
Chiba University Graduate School of Medicine, Department of Neurological Surgery
About Chiba University Graduate School of Medicine, Department of Neurological Surgery
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Detailed information
Job title:
Professor
Homepage URL (1):
https://www.m.chiba-u.jp/dept/neurosurgery/
Research field (1):
Medical biochemistry
Research keywords (7):
proteases and their inhibitors
, 自己免疫疾患における自己抗体
, Autoantibody biomarker
, Atherosclerosis-related disease
, Cancer biomarker
, SEREX
, Gene functional analysis, DSPA
Research theme for competitive and other funds (23):
2019 - 2024 自己抗体マーカーによる睡眠時無呼吸症候群の脳梗塞・心筋梗塞発症予測とモニタリング
2016 - 2022 The Montoring Study on Esophageal Cancer by Serum Autoantibody Targeting RalA and/or NY-ESO-1
2018 - 2021 Comprehensive search of autoantibies in neuroimmunological disorders using a novel hybrid SEREX-FACS method
2017 - 2020 Epidemiological study on the elaboration of the prediction of cerebral infarction by autoantibody markers
2016 - 2019 A potential biomaker with circulating auto-antibodies for cardiovascular disease in patients with obstructive sleep apnea
2015 - 2018 Novel therapeutic strategies for multiple sclerosis targeting autoantibodies against talin.
2014 - 2017 Proteome analysis of toxoplasmic retinochoroiditis-a quest of biomarker
2012 - 2016 Monitoring and Profiling of Serum Autoantibodies for Esophageal Squamous Cell Carcinoma
2011 - 2013 Analysis for Detection of Immunogenic Site on Aquaporin-4 in Neuromyelitis Optica
2008 - 2010 Mechanism of the regulation of thymidylate synthase levels associated with response to 5-fluorouracil in human gastric cancer cells
2006 - 2009 Etiological mechanism of lifestyle-related diseases caused by disordered daily rhythms
2007 - 2008 Application research of a novel tumor suppressor gene, makorin, for diagnosis and therapy of solid tumors
2006 - 2008 Detection of new self-antigens of demyelinating nervous disaeases
2006 - 2007 デコリンのN末端ペブチドはいかにして細胞増殖を両方性に制御するか
2006 - 2007 Multifunctional therapeutic strategy for malignant gliomas targeting cathepsin D
2005 - 2006 Serum anti-myomeglin antibodies is a useful tumor marker to detect gastrointestinal cancer
2005 - 2006 Functional analysis of UBE2I varinat gene isolated by SEREX screening using the sera of patients with esophageal squamous cell carcinoma
2004 - 2006 New SEREX Antigens, Molecular Target to Diagnosis and Treatment for Esophageal Cancer
2004 - 2005 キアリ奇形発生に関与する遺伝子異常および環境要因に関する検討
2004 - 2005 光刺激はいかにして肝臓の遺伝子発現を制御するか
2004 - 2005 Development of glioma-specific peptide vaccine targeting small G-proteins
2003 - 2004 SERUM BIOMARKER FOR BREAST CANCER
2002 - 2004 脳動脈瘤形成メカニズムに関する生化学的および免疫組織学的検討
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Papers (119):
Takaki Hiwasa, Yoichi Yoshida, Masaaki Kubota, Shu-Yang Li, Bo-Shi Zhang, Tomoo Matsutani, Seiichiro Mine, Toshio Machida, Masaaki Ito, Satoshi Yajima, et al. Serum anti-KIAA0513 antibody as a common biomarker for mortal atherosclerotic and cancerous diseases. Medicine International. 2024. 4. 5. 45
Bo-Shi Zhang, Xiao-Meng Zhang, Masaaki Ito, Satoshi Yajima, Kimihiko Yoshida, Mikiko Ohno, Eiichiro Nishi, Hao Wang, Shu-Yang Li, Masaaki Kubota, et al. JMJD6 Autoantibodies as a Potential Biomarker for Inflammation-Related Diseases. International journal of molecular sciences. 2024. 25. 9
Sohei Kobayashi, Takaki Hiwasa, Kouichi Kitamura, Masayuki Kano, Tyuji Hoshino, Sho Hirano, Mayuko Hashimoto, Masanori Seimiya, Hideaki Shimada, Fumio Nomura, et al. Combinational antibody detection approach increases the clinical validity of colorectal cancer screening. Journal of clinical laboratory analysis. 2023. e24978
Toshiki Namiki, Minoru Takemoto, Aiko Hayashi, Hiroki Yamagata, Takahiro Ishikawa, Koutaro Yokote, Shu-Yang Li, Masaaki Kubota, Bo-Shi Zhang, Yoichi Yoshida, et al. Serum anti-PCK1 antibody levels are a prognostic factor for patients with diabetes mellitus. BMC endocrine disorders. 2023. 23. 1. 239-239
島田 英昭, 谷島 聡, 鈴木 隆, 大嶋 陽幸, 名波 竜規, 伊藤 正朗, 白鳥 史明, 船橋 公彦, 日和佐 隆樹. 食道癌における血清自己抗体のバイオマーカーとしての臨床病理学的意義. 日本消化器外科学会総会. 2023. 78回. P240-5
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MISC (193):
谷島聡, 伊藤正朗, 名波竜規, 大嶋陽幸, 鈴木隆, 白鳥史明, 山川輝記, 大久保和範, 大塚由一郎, 船橋公彦, et al. 胃癌患者の解糖系酵素における血清自己抗体の解析. 日本外科学会定期学術集会(Web). 2023. 123rd
山縣 弘規, 日和佐 隆樹, 大西 俊一郎, 吉田 知彦, 竹本 稔. 2型糖尿病患者における血中抗GIP抗体、抗GLP-1抗体測定の臨床的意義に関する検討. 糖尿病. 2022. 65. Suppl.1. S-225
谷島聡, 伊藤正朗, 白鳥史明, 鈴木隆, 名波竜規, 大嶋陽幸, 大久保和範, 大塚由一郎, 船橋公彦, 日和佐隆樹, et al. 胃癌手術症例における血清抗Enolase1抗体の解析. 日本外科学会定期学術集会(Web). 2022. 122nd
谷島聡, 伊藤正朗, 名波竜規, 白鳥史明, 鈴木隆, 大嶋陽幸, 大塚由一郎, 船橋公彦, 日和佐隆樹, 島田英昭. 腫瘍抗原を標的とする胃癌新規抗体マーカーのスクリーニング. 日本外科学会定期学術集会(Web). 2021. 121st
白鳥史明, 日和佐隆樹, 伊藤正朗, 伊藤正朗, 鈴木隆, 谷島聡, 名波竜規, 大嶋陽幸, 船橋公彦, 島田英昭, et al. 食道癌患者血清におけるDAN抗体レベルの上昇. 日本食道学会学術集会抄録集(CD-ROM). 2021. 75th
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Patents (11):
動脈病変を検出し、並びに、脳心臓血管障害、糖尿病、慢性腎臓病、又は固形癌を検出する、体液抗体バイオマーカー
脳梗塞の発症リスクを高感度に検出する体液抗体バイオマーカー
動脈硬化の検出方法
デオキシハイプシン・シンターゼ遺伝子を指標として用いる動脈硬化及びがんの検出方法
脳梗塞の発症リスクを高感度に検出する体液抗体バイオマーカー
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Education (2):
1975 - 1980 The University of Tokyo Graduate School of Science Department of Biophysics and Biochemistry
1971 - 1975 The University of Tokyo Faculty of Science Department of Biophysics and Biochemistry
Professional career (1):
Ph.D. (The University of Tokyo)
Work history (4):
2023/04 - 現在 Chiba University Graduate School of Medicine, Department of Neurological Surgery
2022/10 - 2025/09 Jinan University
2018/04 - 2023/03 Chiba University Graduate School of Medicine Professor
1997/04 - 2018/03 Chiba University Graduate School of Medicine
Association Membership(s) (1):
日本癌学会
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