Rchr

J-GLOBAL ID：200901050648796329 Update date: Jan. 30, 2024

Takahashi Shin'Ichiro

タカハシシンイチロウ | Takahashi Shin'Ichiro

Affiliation and department：
Homepage URL (1)： http://endo.ar.a.u-tokyo.ac.jp/lab/shingroup/index.html

Research field (3)： Animal production science , Food sciences , Applied biochemistry

Research keywords (7)：栄養生化学 , 分子間相互作用 , 分子内分泌 , 生物機能制御 , 動物細胞制御 , Applied Microbiochemistry & Applied Biochemistry , Applied Animal Science

Research theme for competitive and other funds (40)：

2023 - 2026 Elucidation of post-transcriptional regulation mechanism regulated by amino-acid metabolic signal
2023 - 2026 Regulation of insulin-like activities using signaling complexes formed by RNA and IRS-1.
2022 - 2026 Integrated analysis for mitochondrial morphology
2022 - 2025 生体の糖脂質代謝スイッチを誘導するオルニチン情報伝達経路の同定とその制御
2018 - 2021 Regulatory mechanism of ubiquitin modification of insulin receptor substrates and its physiological and pathological significance.

2015 - 2018 Elucidation of molecular mechanisms of alternative splicing of insulin receptor RNA and its physiological significance

2015 - 2018 Tissue specific lipid accumulation in response to amino acid signal

2013 - 2018 Development of methods to regulate abnormality of insulin-like activity by modulation of function of insulin receptor substrates-associated complex

2014 - 2017 The elucidation of growth failure due to GH/IGF signaling abnormality

2012 - 2016 Analysis of insulin resistance through DGKz and development of anti-diabetic medicine

2013 - 2015 Identification and elucidation of the roles of RNAs associated with insulin receptor substrate

2013 - 2015 チアゾリジン化合物のPPARγ非依存性経路を介した新規インスリン作用増強剤の開発

2013 - 2014 動物の一生において時期・組織特異的にインスリン様活性を制御する新規機構とその意義

2009 - 2014 Control of physiological function and behavior by mammalian pheromone

2010 - 2013 Novel mechanisms of growth regulation through changes in ubiquitination of insulin receptor substrates

2011 - 2012 Isolation of drugs which rescue insulin resistance by activating GLUT4 transport activity.

2008 - 2011 Studies on Brain Actions of the Steroid/Growth Factor System

2008 - 2009 mRNAスプライシング制御におけるインスリン受容体基質の新機能解明の試み

2005 - 2007 Interaction of steroid hormones and growth factors in maintaining brain function

2004 - 2007 Novel Molecular Mechanisms Underlying Modulation of Insulin-Like Activities

2003 - 2005 DNA Methylation Analyses in Pathology

2003 - 2004 成長ホルモンにより発生するインスリン抵抗性の原因分子同定のための新しい試み

2001 - 2003 Cross-talk regulatory proteins that function for potentiation of IGF signals in stage-and tissue-specific manners

1999 - 2001 Studies on mechanisms underlying the induction of insulin resistance using transgenic rats

1999 - 2000 New perspectives of the molecular mechanisms to potentiate IGF signals

1996 - 1998 Mechanisms of Modulation of IGF's Action

1995 - 1997 Chromosome mapping of genes in mammals and birds and its applcation for animal resource sciences

1996 - インスリン抵抗性発現機構の解析

1994 - 1995 Modulation of IGF bioactivity by IGF-binding proteins

1993 - 1994 Protein Nutrition and IGF-I and IGF-related Proteins Nutritional Regulation of Biosynthesis and Biological Action of IGF-I and IGF-related Proteins.

1991 - 1992 The interaction between IGF-I-dependent and other hormones-dependent signal pathways in cell growth and differentiation

1991 - インスリン様成長因子及びインスリン様成長因子結合タンパク質の制御機構の解析

1988 - インスリン様成長因子の生理作用調節機構の解析

インスリン様成長因子活性の増強機構の解明と応用

インスリン抵抗性の発生機序の解明と応用

Elucidation of the mechanisms of potentiation of IGF action

Elucidation of the mechanisms of insulin resistance

Regulation of Insulin-like Growth Factors and Their Binding Proteins

Molecular Mechanisms of Insulin resistance

Mechanisms of modulation of insulin-like growth factors' action

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Papers (173)：

Haruka Furuta, Yina Sheng, Ayaka Takahashi, Raku Nagano, Naoyuki Kataoka, Claire Marie Perks, Rachel Barker, Fumihiko Hakuno, Shin-Ichiro Takahashi. The IGF-Independent Role of IRS-2 in the Secretion of MMP-9 Enhances the Growth of Prostate Carcinoma Cell Line PC3. International journal of molecular sciences. 2023. 24. 20
齋藤真希, 西宏起, 宮田市郎, 伯野史彦, 高橋伸一郎. 肝細胞においてアミノ酸欠乏に応答して産生されるFGF21がGH抵抗性誘導に果たす役割の解析. 日本内分泌学会雑誌. 2023. 99. 1. 407-407
Keitaro Yamanouchi, Yukie Tanaka, Masanari Ikeda, Shizuka Kato, Ryosuke Okino, Hiroki Nishi, Fumihiko Hakuno, Shin-Ichiro Takahashi, James Chambers, Takashi Matsuwaki, et al. Macroglossia and less advanced dystrophic change in the tongue muscle of the Duchenne muscular dystrophy rat. Skeletal muscle. 2022. 12. 1. 24-24
Ayaka Zasu, Futa Hishima, Marion Thauvin, Yosuke Yoneyama, Yoichiro Kitani, Fumihiko Hakuno, Michel Volovitch, Shin-Ichiro Takahashi, Sophie Vriz, Christine Rampon, et al. NADPH-Oxidase Derived Hydrogen Peroxide and Irs2b Facilitate Re-oxygenation-Induced Catch-Up Growth in Zebrafish Embryo. Frontiers in Endocrinology. 2022. 13
Hiroki Nishi, Kaito Uchida, Maki Saito, Daisuke Yamanaka, Haruka Nagata, Hinako Tomoshige, Ichiro Miyata, Koichi Ito, Yuka Toyoshima, Shin-Ichiro Takahashi, et al. Essential Amino Acid Intake Is Required for Sustaining Serum Insulin-like Growth Factor-I Levels but Is Not Necessarily Needed for Body Growth. Cells. 2022. 11. 9

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MISC (193)：

高橋伸一郎, 亀井宏泰, 富岡征大, 清家瞳, 永田晋治, 尾添淳文, 伯野史彦. Physiological Significance of Insulin-like Peptide System from Evolutionary Perspective: The Anabolic Hormone Responsible for the Lifelong Health of Animals. 化学と生物. 2022. 60. 5
高橋伸一郎. インスリン様活性を修飾する機構の多様性と生理的意義. ビタミン. 2021. 95. 4. 134-134
伯野史彦, 西宏起, 山中大介, 増田正人, 高橋伸一郎. A novel intervention method in NAFLD. 実験医学. 2021. 39. 5
高橋伸一郎, 伯野史彦, 山中大介, 西宏起, 合田祐貴, 増田正人, 片岡直行, 潮秀樹, 宮本崇史, 豊島由香, et al. 古くて新しいアミノ酸コードの研究. 日本生化学会大会(Web). 2021. 94th
山中大介, 増田正人, 西宏起, 合田祐貴, 伯野史彦, 高橋伸一郎, 伊藤公一. A role for metabolome-mediated amino acid signaling in lipid accumulation in hepatocytes. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th

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Patents (7)：

飼育魚類の脂質含量の低減方法及びそのための飼料
飼育魚類の筋肉内脂質含量増加方法及びそのための飼料
家禽類用飼料および当該飼料を用いた脂肪肝の製造
新しいメカニズムでインスリン様活性を発現するDiacylglycerol kinase (DGK) zのスプライシングバリアントshort-form DGKz (sDGKz)
新規タンパク質IRSAL及び該タンパク質をコードする遺伝子irsal

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Books (2)：

巨大な細胞会社を統御する仕組み
「地球を救う50の提案」世界文化社 2000
Development of a model system to investigate autocrine modalities of growth factor actions(jointly worked)
Growth Factors in Perinatal Development : Raven Press 1993

Works (6)：

New aspects on insulin resistance
2001 - 2002
Molecular mechanisms of insulin resistance induced by GH
1999 - 2002
Mechanisms of potentiation of IGF action
1991 - 2002
インスリン抵抗性の新しい発生機構
2001 -
成長ホルモンによるインスリン抵抗性発生機構
1999 -

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Education (4)：

- 1987 The University of Tokyo
- 1987 The University of Tokyo Graduate School, Division of Agricultural Science
- 1982 Tokyo University of Agriculture and Technology Faculty of Agriculture
- 1982 Tokyo University of Agriculture and Technology Faculty of Agriculture

Professional career (1)：

(BLANK) (The University of Tokyo)

Work history (10)：

2007/04 - 現在 The University of Tokyo Graduate School of Agricultural and Life Sciences, Animal Resource Sciences
1994 - 2007 The University of Tokyo Graduate School of Agricultural and Life Sciences
2001 - 2003 Ministry of Education,Culture,Sports,Science and Technology
1990 - 1994 東京大学農学部助教授
1990 - 1994 The University of Tokyo, Associate Professor

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Awards (4)：

2008/06 - ノボノルディスク成長・発達研究賞成長ホルモンにより発生するインスリン抵抗性の原因分子の同定
2003/06 - 第7回Novo-Nordisk Growth賞成長ホルモンにより発生するインスリン抵抗性の原因分子同定のための新しい試み
2000/06 - 第4回Novo-Nordisk Growth賞 IRSを介したシグナル伝達機構研究の新展開
1992/01 - 成長科学協会成長ホルモン研究奨励賞タンパク質栄養状態に応答したインスリン様成長因子I活性調節機構の分子細胞生物学的解析

Association Membership(s) (5)：

IGF研究会 , 日本内分泌学会 , 内分泌学会(The Endocrine Society) , 日本生化学会 , 日本農芸化学会

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