Rchr

J-GLOBAL ID：200901050763321857 Update date: Apr. 09, 2024

Tokunaga Katsushi

トクナガカツシ | Tokunaga Katsushi

Affiliation and department：
Job title： Professor

Research field (1)： Medical biochemistry

Research keywords (6)：ヒトゲノム多様性 , 多因子疾患 , ゲノム医学 , Human genome diversity , Multifactorial disease , Medical genomics

Research theme for competitive and other funds (89)：

2023 - 2026 ゲノム医療の法的基盤整備に向けた多分野横断的研究
2018 - 2022 臨床研究の包括的法規制のあり方に関する多分野横断的研究
2016 - 2021 Integrated Research into the Processes and Mechanisms of Racialization
2016 - 2021 日本人大規模全ゲノム情報を基盤とした多因子疾患関連遺伝子の同定を加速する情報解析技術の開発と応用
2017 - 2020 Analysis of the genetic predictor to the onset of MTX-LPD for the genomic medicine

2015 - 2019 Searching for susceptibility genes for narcolepsy, and their application for precision medicine

2015 - 2018 Searching for the genetic factors predisposing to PBC

2015 - 2018 Identification of human genetic factors associated with tuberculosis and associated diseases through the meta-analysis and new statistical approaches

2015 - 2018 Molecular epidemiology study of inflammation-associated disease development on the basis of long-term follow-up of atomic-bomb survivors

2015 - 2018 Promotion of molecular epidemiological studies of H. pylori in Asia

2014 - 2018 効果的な結核症対策へ向けたヒトと病原菌のゲノム情報の統合的活用

2014 - 2017 Suseptible genes for essential blepharospasmus

2012 - 2017 Genome-wide DNA analysis on people with family name "Japan" in Spain who are presumed as descendants of a part of the delegation to Rope by Masamune Date

2011 - 2016 Human dispersal history in Southeast Asia and Oceania

2010 - 2016 A-Japan Based Global Study of Racial Representations

2010 - 2016 Platform of large scale and high quality genomics and bioinformatics: Towards the advancement of genome sciences in academia

2014 - 2016 ゲノム網羅的解析によるB型肝炎ウイルス感染の病態関連遺伝子の同定と新規診断法の開発

2014 - 2016 個別化医療に向けたヒトゲノムバリエーションデーターベース

2012 - 2015 Pharmacogenomics study of anti-tuberculosis drugs in the Asian population

2012 - 2015 Elucidation to Pathogenetic Mechanism of Nephrotic Proteinuria through Genetic and Functional Analysis

2012 - 2015 Molecular epidemiology study of inflammation-associated disease development on the basis of long-term follow-up of atomic-bomb survivors

2010 - 2015 Integrated redearch for HLA disease and evolution

2010 - 2015 HLA遺伝子群の多様性と疾病解析

2011 - 2014 The mechanism of regulation to occur the migraine

2011 - 2013 Study of susceptible gene for optic neuritis

2010 - 2012 Research of genetic factor for childhood-onset Type 1 diabetes

2010 - 2012 Strategic research for elucidation of molecular pathophysiology and identification of therapeutic target of lumbar spondylosis

2009 - 2011 Genetic analysis of susceptibility genes for osteoarthritis of the knee joing

2009 - 2011 結核を対象とした国際遺伝疫学研究および研究開発ネットワーク構築

2008 - 2010 Research for genes associated with glaucoma

2007 - 2009 Studies on the genetic factors, environmental factors and their interactions towards the establishment of genome medicine of rheumatic diseases

2005 - 2009 Support of genotyping to identify genes involved in human diseases

2005 - 2009 Establishment of the support system for SNP analyses and identification of disease-associated genes

2005 - 2009 Genome medical research supporting committee

2004 - 2009 Comprehensive genomics towards the frontiers of biology and med

2004 - 2007 Development of SNP catalog toward to disease mapping by sequence determination of the HLA haplotypes

2007 - ゲノムワイド関連分析データベース

2006 - 2006 ネグリトの起源と適応に関する分子人類学的研究

2003 - 2005 Research on DNA and morphological analysis of the ancient brain and human skeleton

2000 - 2005 Genomic analysis on genetic factors of human diseases and elucidation of their molecular mechanisms

2002 - 2004 A genetic-ecological study of the risk foctors for lifestyle-related diseases in Oceanian populations

2002 - 2004 Preclinical tests for gene therapy of advanced heart failure

2000 - 2004 Genes associated with rheumatic and diffuse collagen diseases

2002 - 2003 Development of the diagnostic methods for the intrinsic factor of the maxillo-facial deformity using HLA and the related genes

2002 - 2003 The investigation of the developing mechanism in abnormal morphogenesis and application to the genetic diagnosis

2002 - 2003 Phylogenetic analyses of the HLA-DRB1 gene based on the DR haplotypes

2001 - 2003 Polymorphisms and disease associations of receptor gene families for class I antigens

2000 - 2003 Prehistoric Study on Evolutionary Processes of the Lapita People to Polynesians in the South Pacific

2001 - 2002 The elucidation of pathoenic mechanism of cranio-maxillo-facial anomdy and the applicaton for gene diagnosis

2000 - 2002 Development of new SNP typing technologies for searching disease-associated genes.

2000 - 2002 Studies on the clinical significance of TNFα upstream promoter region haplotypes.

1999 - 2002 Genome Scan of Candidate Region of Schizophrenia using DNA Pooling Method

2002 - SNPタイピングセンターおよび技術開発

2000 - 2001 Search for genetic factors associated with sleep and circadian rhythm disorders

2000 - 2001 Chronological gene expression profile in acute renal failure using CDNA array method

2000 - 2001 Investigation of HCA, neurodevelopmental genes and related environmental factors in schizophrenia

1999 - 2001 Genetic Origins of Minority Groups in China and Thailand

2001 - SNP typing center and technology development

2000 - 2000 マイクロサテライト解析によるびまん性汎細気管支炎の主要感受性遺伝子座の推定

1999 - 2000 Study on interactions between infectious diseases and host genetic factors in East Asia and Oceania

1997 - 2000 Origins and Formations of Japanese Peoples from the Perspectives of Morphological and Molecular Anthropology.

1998 - 1999 Study on ability of Maxillo-facial growth in the patients with congenital anomalies by HLA-typing

1997 - 1999 Development of high-resolution DNA typing methods for HLA class 1 genes.

1998 - 1998 ヒト遺伝子の多様性:その由来と医学・生物学的意義

1998 - 1998 分子遺伝学的アプローチによるクローン病感受性遺伝子同定の試み

1997 - 1998 Study on genetic and cultural diversity of Hans in China

1996 - 1998 Genetic-ecological study on the human population adaptation and survival in two Oceanic populations.

1998 - 感染症に関わるヒトの遺伝要因

1998 - Human genetic factors for infectious diseases

1993 - 1994 Genetic contribution of MHC class II and III genes to pathogenesis of RA and PSS.

1992 - 1992 主要組織適合抗原システムからみた東アジアにおける民族移動

1990 - 1992 乾癬患者の遺伝的マーカーおよび疾患感受性遺伝子の分子レベルでの解析

1990 - 1992 Study for genetical background of arthritis rheumatism on MNC clacc II and III antigens.

1989 - 1992 ORIGINES AND AFFINITIES OF DIPERSAL POPULATIONS (PHYSICAL ANTHROPOLOGY)

1991 - 1991 主要組織適合抗原システムからみた東アジアにおける民族移動

1991 - 1991 拡散集団の起源・系統(自然人類学)

1990 - 1990 ナルコレプシ-発症遺伝子の検索と解析

1990 - 1990 拡散集団の起源・系統(自然人類学)

1990 - 1990 Common HLA Haplotypes in Korean and Japanese

1989 - 1989 拡散集団の起源・系統(自然人類学)

1989 - 1989 ナルコレプシ-発症に関与するHLA領域遺伝子群の解析

1988 - 1989 DETERMINATION OF FREQUENCIES OF HLA HAPLOTYPES IN TOHOKU AREA BASED ON FAMILY STUDY AND EVALUTION OF AN APPROPRIATE SIZE OF UNRELATED DONOR POOL FOR HLA-MATCHED PLATELET TRANSFUSION AND BONE MARROW TRANSPLANTATION

1986 - 1988 MOLECULAR ANTHROPOLOGICAL STUDY OF EVOLUTION OF IMMUNOLOGICAL MULTIGENE FAMILY

1985 - 睡眠障害の遺伝要因

1985 - Susceptibility genes for sleep disorders

1984 - 1984 新しい免疫学的方法を用いたヒトの遺伝的変異に関する研究

1978 - ヒトのゲノム多様性

1978 - Molecular diversity of human genome

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Papers (728)：

Eisei Noiri, Daisuke Katagiri, Yusuke Asai, Takeshi Sugaya, Katsushi Tokunaga. Urine oxygenation predicts COVID-19 risk. Clinical and experimental nephrology. 2024
Mihoko Shimada, Yosuke Omae, Akiyoshi Kakita, Ramil Gabdulkhaev, Yuki Hitomi, Taku Miyagawa, Makoto Honda, Akihiro Fujimoto, Katsushi Tokunaga. Identification of region-specific gene isoforms in the human brain using long-read transcriptome sequencing. Science advances. 2024. 10. 4. eadj5279
Yosuke Kawai, Yusuke Watanabe, Yosuke Omae, Reiko Miyahara, Seik-Soon Khor, Eisei Noiri, Koji Kitajima, Hideyuki Shimanuki, Hiroyuki Gatanaga, Kenichiro Hata, et al. Exploring the genetic diversity of the Japanese population: Insights from a large-scale whole genome sequencing analysis. PLoS genetics. 2023. 19. 12. e1010625
Keiji Tachikawa, Takahiro Shimizu, Takeshi Imai, Riyoko Ko, Yosuke Kawai, Yosuke Omae, Katsushi Tokunaga, Martin C Frith, Yoshihisa Yamano, Satomi Mitsuhashi. Cost-Effective Cas9-Mediated Targeted Sequencing of Spinocerebellar Ataxia Repeat Expansions. The Journal of molecular diagnostics : JMD. 2023
Yuki Hitomi, Kazuko Ueno, Yoshihiro Aiba, Nao Nishida, Yosuke Kawai, Minae Kawashima, Seik-Soon Khor, Sanami Takada, Chisato Iwabuchi, Masao Nagasaki, et al. rs10924104 in the expression enhancer motif of CD58 confers susceptibility to human autoimmune diseases. Human genetics. 2023

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MISC (351)：

人見祐基, 相葉佳洋, 植野和子, 西田奈央, 河合洋介, 川嶋実苗, 築地信, 岩渕千里, 高田紗奈美, 三宅紀子, et al. 様々な免疫形質と関連するCD28領域におけるスプライシング制御バリアントの同定. 日本人類遺伝学会大会プログラム・抄録集. 2022. 67th (CD-ROM)
長崎正朗, 長崎正朗, 山口泉, 川口喬久, 寺岡亮, 稲富雄一, 深沢圭一郎, 関谷勇司, 塙敏博, 大川恭行, et al. Large-Scale Human Genome Analysis in Genomic Medicine and Utilization of Hybrid Cloud Computing System. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
人見祐基, 相葉佳洋, 植野和子, 西田奈央, 河合洋介, 川嶋実苗, 安波道朗, GERVAIS Olivier, 長崎正朗, 徳永勝士, et al. 原発性胆汁性胆管炎(PBC)感受性遺伝子CCR6/FGFR1OPにおけるprimary functional variantsの同定. 日本人類遺伝学会大会プログラム・抄録集. 2021. 66th (CD-ROM)
宮寺浩子, 吉山崇, 永井英明, 徳永勝士, 星野仁彦. HLAクラスII-ペプチド結合測定系の開発と評価. 日本臨床免疫学会総会プログラム・抄録集. 2019. 47回. 116-116
人見祐基, 河合洋介, 植野和子, 西田奈央, 川嶋実苗, 相葉佳洋, 築地信, 長崎正朗, 中村稔, 徳永勝士. 原発性胆汁性胆管炎(PBC)感受性遺伝子領域を対象とした機能的遺伝子多型(causal variant)の同定. MHC: Major Histocompatibility Complex. 2019. 26. 2Suppl. 104-104

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Patents (2)：

方法及び診断薬
結核菌遺伝系統特異的に結核症発症のリスクを判定する方法

Books (2)：

人類遺伝学ノート
南山堂 2007
On the origin and dispersal of East Asian populations as viewed from HLA haplotypes.
In : Prehistoric Mongoloid Dispersals Oxford University Press 1996

Lectures and oral presentations (9)：

HLA immunogenetics in autoimmunity, allergy, and infectious disease
(Federation of Clinical Immunology Societies 2018 2018)
Recent Genomic Approach to Complex Diseases
(The 3rd International Stevens-Johnson Syndrome Symposium 2018)
感染症におけるヒトゲノム・病原体ゲノム解析: シンポジウム「ゲノム医科学の新展開」
(生命科学系学会合同年次大会 2017)
東北メディカル・メガバンク機構からの試料・情報の分譲
(東北メディカル・メガバンクのゲノムデータを活用した研究の推進、バイオバンクのリソース活用 2017)
Understanding HLA associations with disease susceptibility and drug hypersensitivity
(11th International Symposium on Rare Disease Research 2017)

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Works (2)：

Analysis of human gene diversity
2001 - 2005
System for gene expression analysis
1998 - 2002

Education (4)：

- 1982 The University of Tokyo
- 1982 The University of Tokyo Graduate School, Division of Science
- 1977 The University of Tokyo Faculty of Science Department of Biological Sciences
- 1977 The University of Tokyo Faculty of Science

Professional career (1)：

Doctor of Science (The University of Tokyo)

Work history (15)：

1995 - 現在東京大学医学系研究科教授
1995 - 現在 University of Tokyo, Graduate School of
1992 - 1995 日本赤十字中央血液センター研究部課長
1992 - 1995 Japanese Red Cross Central Blood Center,
1989 - 1992 The University of Tokyo Faculty of Medicine University Hospital

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Committee career (11)：

2016 - 現在日本組織適合性学会理事長
2011 - 現在文部科学省科学技術・学術審議会専門委員会委員
2007 - 現在日本人類遺伝学会理事、編集長
2006 - 現在日本学術会議連携会員
1999 - 現在日本DNA多型学会評議員

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Awards (5)：

2015 - 日本人類遺伝学会学会賞
1996 - 日本輸血学会奨励賞
1996 - Young Scholars Award of The Japan Society of Blood Transfusion
1990 - 日本人類遺伝学会奨励賞
1990 - Young Scholars Award of The Japan Society of Human Genetics

Association Membership(s) (8)：

アメリカ組織適合性学会 , DNA多型学会 , アメリカ人類遺伝学会 , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , 人類学会 , 免疫学会 , 組織適合性学会 , 人類遺伝学会

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