Rchr
J-GLOBAL ID：200901051111671143   Update date: Sep. 10, 2024

Nagata Naoto

ナガタ ナオト | Nagata Naoto
Affiliation and department：
Kanazawa University

About Kanazawa University


Job title： Lecturer
Homepage URL  (1)： http://saiboubunshikinoh.wixsite.com/home
Research field  (4)： Clinical pharmacy ,  Food sciences ,  Gastroenterology ,  Metabolism and endocrinology
Research keywords  (3)： 酸化ストレス ,  NAFLD ,  Energy metabolism
Research theme for competitive and other funds  (6)：
  • 2022 - 2025 Nrf2による腸管からの脂肪吸収抑制機構の解明と肥満治療への応用に向けた基礎研究
  • 2018 - 2021 酸化ストレス応答転写因子Nrf2によるエネルギー代謝調節機構の解明
  • 2016 - 2019 Research and development for energy expending anti-obesity functional food
  • 2015 - 2017 ブロッコリースプラウト抽出物による炎症制御及びエネルギー代謝調節機構の解明
  • 2013 - 2014 タンパク質チロシンフォスファターゼShp2による炎症制御機構の解明
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Papers (77)：
  • Guanliang Chen, Yanwen Yu, Yuqin Zhu, Mayumi Nagashimada, Yajiao Wang, Naoto Nagata, Liang Xu. Cenicriviroc Suppresses and Reverses Steatohepatitis by Regulating Macrophage Infiltration and M2 Polarization in Mice. Endocrinology. 2024. 165. 7
  • Suratsawadee Promsuwan, Kazuki Sawamoto, Liang Xu, Mayumi Nagashimada, Naoto Nagata, Yumi Takiyama. A natural Nrf2 activator glucoraphanin improves hepatic steatosis in high-fat diet-induced obese male mice associated with AMPK activation. Diabetology international. 2024. 15. 1. 86-98
  • Kotomi Miura, Jun-Ichi Morishige, Jotaro Abe, Pingping Xu, Yifan Shi, Zheng Jing, Naoto Nagata, Ryo Miyazaki, Naoki Sakane, Michihiro Mieda, et al. Imeglimin profoundly affects the circadian clock in mouse embryonic fibroblasts. Journal of pharmacological sciences. 2023. 153. 4. 215-220
  • Jun-ichi Morishige, Kazuaki Yoshioka, Hiroki Nakata, Kazuhiro Ishimaru, Naoto Nagata, Tamotsu Tanaka, Yoh Takuwa, Hitoshi Ando. Sphingosine Kinase 1 is Involved in Triglyceride Breakdown by Maintaining Lysosomal Integrity in Brown Adipocytes. Journal of Lipid Research. 2023. 64. 11. 100450
  • Zheng Jing, Tomohiro Iba, Hisamichi Naito, Pingping Xu, Jun-Ichi Morishige, Naoto Nagata, Hironao Okubo, Hitoshi Ando. L-carnitine prevents lenvatinib-induced muscle toxicity without impairment of the anti-angiogenic efficacy. Frontiers in pharmacology. 2023. 14. 1182788-1182788
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MISC (54)：
  • MORISHIGE Jun-ichi, YOSHIOKA Kazuaki, NAGATA Naoto, TAKANA Tamotsu, TAKUWA Yoh, ANDO Hitoshi. Functional Analysis of Sphingosine Kinase 1 in Brown Adipose Tissue. 日本薬理学会年会要旨集(Web). 2023. 97th
  • 許平平, 盛重純一, 靖ジョウ, 長田直人, 安藤仁. GLP-1受容体作動薬は中枢神経への直接作用を介して肝の体内時計障害を改善する. 糖尿病(Web). 2023. 66. Suppl
  • 安部丈太郎, 三浦琴美, 盛重純一, 許平平, 史一帆, 靖崢, 長田直人, 三枝理博, 安藤仁. イメグリミンはメトホルミンとは異なり体内時計に強力に作用する. 時間生物学. 2023. 29. 2
  • SURATSAWADEE Promsuwan, 澤本一樹, 長田直人, XU Liang, 滝山由美. グルコラファニンによる肥満・脂肪肝に対する治療効果. 糖尿病合併症. 2022. 36. Supplement-1
  • 澤本一樹, 長田直人, PROMSUWAN Suratsawadee, XU Liang. グルコラファニンによる肥満・インスリン抵抗性に対する治療効果. 糖尿病(Web). 2020. 63. Suppl
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Patents (2)：
  • LPS産生抑制剤、及びLPS産生抑制用の食品組成物
  • 非アルコール性脂肪性肝疾患予防用又は治療用組成物の製造方法
Books (4)：
  • スルフォラファンの肥満抑制効果
    シーエムシー出版 2018
  • Fatty liver and insulin resistance
    IGAKU SHUPPAN 2013 ISBN:9784287820520
  • Diabetes Frontier 脂肪肝と炎症~NASH発症の分子機構~
    メディカルレビュー社 2008
  • メディカルプラクティス 高脂血症がもたらす臓器障害
    文光堂 2007
Lectures and oral presentations  (56)：
  • グルコラファニンによる肥満・脂肪肝に対する治療効果
    (第37回日本糖尿病合併症学会抄録 2022)
  • Glucoraphanin has the therapeutic potential of resolving hepatic steatosis in a murine model of diet-induced obesity
    (IDF2021 2021)
  • 抗凝固薬エドキサバンの時間薬理学的検討
    (第42回日本臨床薬理学会学術総会 2021)
  • Impact of a dosing-time-dependent effect of edoxaban on coagulation activity in rats
    (2019)
  • Nrf2 activation by glucoraphanin alleviates high-fat diet-induced obesity and insulin resistance through adipose tissue browning.
    (Environmental Response V 2019)
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Education (3)：
  • 2004 - 2007 Kanazawa University
  • 2002 - 2004 Kanazawa University Graduate School of Natural Science and Technology
  • 1998 - 2002 Kanazawa Uiversity
Professional career (1)：
  • Pharm D
Work history (6)：
  • 2017/07 - 現在 Kanazawa University Graduate School of Medical Science Lecuturer
  • 2016/09 - 2017/06 Kanazawa University Graduate School of Medical Science Department of Cellular and Molecular Function Analysis Assistant professor
  • 2012/10/01 - 2016/08/31 Kanazawa University Assistant Professor
  • 2010/02/01 - 2012/08/31 University of California, Davis Department of Nutrition Postdoctoral fellow
  • 2008/04 - 2010/01 Kanazawa University Graduate School of Natural Science Assistant Professor
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Association Membership(s) (3)：
The Japanese Biochemical Society ,  Japanese Association for Protein Phosphatase Research ,  The Japan Society of Hepatology
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