Rchr
J-GLOBAL ID:200901051214378797
Update date: Jan. 31, 2024
Kadowaki Tomoko
カドワキ トモコ | Kadowaki Tomoko
Affiliation and department:
Homepage URL (1):
http://www.mdp.nagasaki-u.ac.jp/frontier/
Research field (4):
Community dentistry
, Oral medicine (pathology)
, Allergies and connective tissue disease
, Oral medicine
Research keywords (4):
Immunology
, 細菌学
, 細胞生物学
, 歯科薬理学
Research theme for competitive and other funds (27):
- 2023 - 2027 コホートを用いた歯周病と全身炎症を繋ぐ分子基盤の解明と病態制御への応用
- 2021 - 2024 歯周病発症における新規小胞輸送因子の分子機構の解析
- 2021 - 2024 Multimodal imaging analysis of oral cancer cells focused on lysosomes
- 2020 - 2023 Functional and pathological analyses of inflammatory bone destruction disease by a novel Rab protein
- 2020 - 2023 メカノセンサーを標的とした歯周病制御
- 2019 - 2022 Function of a novel Rab protein in neutrophils and its role in periodontal disease
- 2018 - 2022 新規Rabタンパク質によるマスト細胞脱顆粒の制御機構解明
- 2017 - 2020 Discovery of a novel gene regulating membrane trafficking of immune cells and elucidation of its pathology
- 2016 - 2018 Elucidation of cascade regulation by two different control systems of the type IX secretion system
- 2016 - 2018 Analyses using bioimaging of invasion and colonization mechanisms by periodontal bacteria in the liver
- 2015 - 2018 Elucidation of chronic inflammation exacerbation mechanism due to breakdown of endo-lysosomal proteolysis
- 2012 - 2015 Relationship between periodontal infection and HIV infection in Kenya using simultaneous microsphere-based multiplex assays
- 2012 - 2013 歯周病細菌における病原性因子分泌調節メカニズムの解明
- 2010 - 2012 Dual regulation of secretion system of periodontal virulence factors by novel two-component system and ECF sigma factor
- 2009 - 2012 Investigation of the secretion system of pathogenic proteinases in Porphyromonas gingivalis and study of the way to control the system
- 2007 - 2010 Protease-mediated regulation of host immune system and application as therapeutic targets
- 2007 - 2009 Experimental analysis of the correlation between periodontal disease and insulin resistance
- 2006 - 2008 Function of endo-lysosomal proteinases in epithelial cells
- 2004 - 2006 生体防御系におけるプロテアーゼの機能解析
- 2004 - 2006 Examination of biological response to Porphyromonas gingivalis infection.
- 2003 - 2006 Molecular basis of host immune responses to periodontal disease
- 2001 - 2005 ESTABLISHMENT OF A CLINICAL TREATMENT SYSTEM FOR PERIODONTAL DISEASE
- 2000 - 2005 神経系におけるオートファジー・リソソームシステム
- 2002 - 2004 歯周病における免疫制御系プロテアーゼの機能解析
- 2002 - 2004 歯周病原性プロテアーゼに対する生体反応と心循環系傷害機序に関する研究
- 1999 - 2002 MOLECULAR BASIS OF PROTEINASE FUNCTION IN PROGRESSION OF PERIODONTAL DISEASES
- 1997 - 2000 歯周病関連細菌の病原性因子解析と病態に 関する研究
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Papers (88):
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Ayuko Tanimoto, Yu Yamaguchi, Tomoko Kadowaki, Eiko Sakai, Shun Oyakawa, Yusuke Ono, Noriaki Yoshida, Takayuki Tsukuba. Rab44 negatively regulates myoblast differentiation by controlling fusogenic protein transport and mTORC1 signaling. Journal of cellular biochemistry. 2023
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Shun Oyakawa, Yu Yamaguchi, Tomoko Kadowaki, Eiko Sakai, Mayuko Noguromi, Ayuko Tanimoto, Yusuke Ono, Hiroshi Murata, Takayuki Tsukuba. Rab44 deficiency accelerates recovery from muscle damage by regulating mTORC1 signaling and transport of fusogenic regulators. Journal of cellular physiology. 2023
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Mayuko Noguromi, Yu Yamaguchi, Keiko Sato, Shun Oyakawa, Kuniaki Okamoto, Hiroshi Murata, Takayuki Tsukuba, Tomoko Kadowaki. Rab44 Deficiency Induces Impaired Immune Responses to Nickel Allergy. International journal of molecular sciences. 2023. 24. 2. 994
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Yoshio Kondo, Kenichi Ohara, Ryoji Fujii, Yudai Nakai, Chikara Sato, Mariko Naito, Takayuki Tsukuba, Tomoko Kadowaki, Keiko Sato. Transposon mutagenesis and genome sequencing identify two novel, tandem genes involved in the colony spreading of Flavobacterium collinsii, isolated from an ayu fish, Plecoglossus altivelis. Frontiers in cellular and infection microbiology. 2023. 13. 1095919-1095919
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Manh Tien Tran, Yuka Okusha, Kaung Htike, Chiharu Sogawa, Takanori Eguchi, Tomoko Kadowaki, Eiko Sakai, Takayuki Tsukuba, Kuniaki Okamoto. HSP90 drives the Rab11a-mediated vesicular transport of the cell surface receptors in osteoclasts. Cell biochemistry and function. 2022. 40. 8. 838-855
more...
MISC (86):
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Noguromi M, Yamaguchi Y, Sato K, Murata H, Tsukuba T, Kadowaki T. Roles of the large G protein Rab44 in metal allergy. MBSJ2022 online Programs&Abstracts. 2022. 3P-103
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Oyakawa S, Yamaguchi Y, Kadowaki T, Tanimoto A, Sakai E, Murata H, Tsukuba T. Effects of a large Rab protein on muscle satellite cells and myogenesis. 2022. 95回. 2P-168
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Tanimoto A, Yamaguchi Y, Kadowaki T, Oyakawa S, Sakai E, Ono Y, Yoshida N, Tsukuba T. Differentiation mechanisms of myoblasts into myotubes controlled by a large Rab protein. 2022
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Yamaguchi Y, Kadowaki T, Aibara N, Ohyama K, Okamoto K, Sakai E, Tsukuba T. Coronin1C is a GDP-specific Rab44 effector that controls osteoclast formation by regulating cell motility in macrophages. 2022
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Kadowaki T, Yamaguchi Y, Sato K, Tsukuba T. Regulatory mechanisms of inflammatory responses by Rab44 protein. Journal of Oral Bioscience, supplement. 2022. 369
more...
Books (8):
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歯周病とプロテアーゼ-歯周病原性細菌のヘムおよびアミノ酸獲得機序-
蛋白質分解 2000
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Arg-gingipain and Lys-gingipain: a novel class of cysteine proteinases.
Proteases: New Perspectives, Birkh隔sen Verlag 1999
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Arg-gingipain and Lys-gingipain : a novel class of cysteine proteinases.
Proteinases : New Perspectives 1999
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Structural Characterization of Pathogenic Cysteine Proteinases from the Oral Bacterium Porphyromonas gingivalis.
Proteolysis in Cell Functions, IOS Press, Amsterdam 1997
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Biological Roles of a Novel Class of Cysteine Proteinases from Porphyromonas gingivalis in Periodontal Disease Progression.
"Medical Aspects of Proteases and Protease Inhiibitors" 1997
more...
Lectures and oral presentations (9):
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Lysosomal trafficking involved in allergic responses
(2020)
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基礎研究,URA,ワーク・ライフバランスから見た研究戦略
(第60回歯科基礎医学会学術大会 2018)
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Porphyromonas gingivalis を標的とした創薬
(第47回歯科基礎医学会学術大会 2005)
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Porphyromonas gingivalisプロテアーゼによる宿主細胞傷害機構
(第78回日本細菌学会総会 2005)
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Development of potent gingipain inhibitors as tools to prevent the virulence of Porphyromonas gingivalis
(3rd General Meeting of the International Proteolysis Society 2003)
more...
Education (4):
- 1991 - 1995 Kyushu University
- - 1995 Kyushu University Graduate School, Division of Dental Research
- 1984 - 1990 Kyushu University School of Dentistry
- - 1990 Kyushu University Faculty of Dentistry
Professional career (1):
- (BLANK) (Kyushu University)
Work history (10):
- 2021/03 - 現在 Nagasaki University Graduate School of Biomedical Sciences
- 2014/11 - 2021/02 Nagasaki University Graduate School of Biomedical Sciences associate professor
- 2012/02 - 2014/10 Nagasaki University
- 2009/04 - 2012/01 Nagasaki University
- 2008/04 - 2009/03 Kyushu University
- 2001/04 - 2008/03 Kyushu University Faculty of Dental Science assistant professor
- 2000/04 - 2001/03 科学技術振興事業団 基礎研究推進部 研究補助員
- 1997/04 - 2000/03 日本学術振興会 特別研究員
- 1997/10 - 1999/03 米国ペンシルバニア州立大学 医学部 博士研究員
- 1990/07 - 1991/03 Kyushu University School of Dentistry
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Committee career (1):
- 2022/09 - Japanese Association for Oral Biology delegate
Awards (3):
- 2004 - JB論文賞
- 2002 - 優秀演題賞
- 1999 - 歯科基礎医学会賞
Association Membership(s) (3):
日本分子生物学会
, 歯科基礎医学会
, 日本生化学会
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