Rchr
J-GLOBAL ID：200901051287841894   Update date: Feb. 09, 2024

Toyomura Takao

Toyomura Takao
Affiliation and department：
Shujitsu University School of Pharmacy, Department of Pharmaceutical Sciences

About Shujitsu University School of Pharmacy, Department of Pharmaceutical Sciences


Research field  (3)： Pharmacology ,  Molecular biology ,  Cell biology
Research keywords  (11)： 代謝性疾患 ,  細胞生物学 ,  分子生物学 ,  生化学 ,  創薬 ,  合併症 ,  糖尿病 ,  炎症 ,  osteoclast ,  bone metabolism ,  differentiation
Research theme for competitive and other funds  (7)：
  • 2021 - 2024 内因性AGEによる組織リモデリング増悪化機構の解明と新規標的治療法の創成
  • 2021 - 2024 炎症抑制性DAMPsの新規同定と炎症性疾患における病態生理学的意義の解明
  • 2018 - 2021 Study of the pathophysiological significance of endogenous AGE as an exacerbating factor for tissue remodeling, and the development of novel targeted therapy
  • 2015 - 2018 Roles of AGEs as exacerbation factor in pathogenesis of tissue remodeling and the development of novel targeted therapy
  • 2015 - 2017 Elucidating the molecular bases and pathophysiological significances of the extracellular inflammasome which drives chronic inflammation
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Papers (19)：
  • Masahiro Watanabe, Takao Toyomura, Hidenori Wake, Takashi Nishinaka, Omer Faruk Hatipoglu, Hideo Takahashi, Masahiro Nishibori, Shuji Mori. Cationic ribosomal proteins can inhibit pro-inflammatory action stimulated by LPS+HMGB1 and are hindered by advanced glycation end products. Biotechnology and applied biochemistry. 2023
  • Takashi Nishinaka, Omer Faruk Hatipoglu, Hidenori Wake, Masahiro Watanabe, Takao Toyomura, Shuji Mori, Masahiro Nishibori, Hideo Takahashi. Different modulation of STING/TBK1/IRF3 signaling by advanced glycation end products. Archives of biochemistry and biophysics. 2023. 750. 109808-109808
  • Takao Toyomura, Masahiro Watanabe, Hidenori Wake, Takashi Nishinaka, Omer Faruk Hatipoglu, Hideo Takahashi, Masahiro Nishibori, Shuji Mori. Glycolaldehyde-derived advanced glycation end products promote macrophage proliferation via the JAK-STAT signaling pathway. Molecular Biology Reports. 2023. 50. 7. 5849-5858
  • Omer Faruk Hatipoglu, Takashi Nishinaka, Masahiro Nishibori, Masahiro Watanabe, Takao Toyomura, Shuji Mori, Kursat Oguz Yaykasli, Hidenori Wake, Hideo Takahashi. Histamine promotes angiogenesis through a histamine H1 receptor-PKC-VEGF-mediated pathway in human endothelial cells. Journal of pharmacological sciences. 2023. 151. 4. 177-186
  • Takashi Nishinaka, Omer Faruk Hatipoglu, Hidenori Wake, Masahiro Watanabe, Takao Toyomura, Shuji Mori, Masahiro Nishibori, Hideo Takahashi. Glycolaldehyde-derived advanced glycation end products suppress STING/TBK1/IRF3 signaling via CD36. Life sciences. 2022. 310. 121116-121116
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MISC (14)：
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Lectures and oral presentations  (30)：
  • グリコールアルデヒド由来AGEsによるマクロファージ増殖亢進
    (日本薬学会年会要旨集 2022)
  • グリコールアルデヒド由来AGEsによる細胞増殖機構
    (日本生化学会大会プログラム・講演要旨集 2021)
  • 終末糖化産物によるLPS-HMGB1共刺激炎症応答の相乗的活性化作用
    (日本生化学会大会プログラム・講演要旨集 2021)
  • TLR2はAGE2刺激による細胞増殖を抑制する
    (日本薬学会年会要旨集 2021)
  • 終末糖化産物はLPS-HMGB1刺激性炎症応答を相乗的に亢進する
    (日本薬学会年会要旨集 2021)
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Education (3)：
  • 1998 - 2001 大阪大学大学院博士課程 理学研究科 生物科学専攻
  • 1996 - 1998 甲南大学大学院修士課程 自然科学研究科 生物学専攻
  • 1992 - 1996 Konan University
Professional career (1)：
  • 博士(理学) (大阪大学)
Work history (6)：
  • 2022/04 - 現在 就実大学薬学部薬学科 生体情報学研究室 准教授
  • 2015/04 - 2022/03 Shujitsu University
  • 2007/04 - 2015/03 Shujitsu University School of Pharmacy, Department of Clinical Pharmacy
  • 2005/09 - 2007/03 Shujitsu University School of Pharmacy, Department of Clinical Pharmacy
  • 2004/04 - 2005/08 Osaka University of Pharmaceutical Sciences
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Association Membership(s) (4)：
日本薬学教育学会 ,  THE PHARMACEUTICAL SOCIETY OF JAPAN ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  THE JAPANESE BIOCHEMICAL SOCIETY
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