Muto Akihiko

ムトウアキヒコ | Muto Akihiko

Affiliation and department：
Job title： Associate Professor
Homepage URL (2)： http://www.biochem.med.tohoku.ac.jp , http://www.biochem.med.tohoku.ac.jp/english/en_index.html

Research field (1)： Medical biochemistry

Research theme for competitive and other funds (21)：

2022 - 2025 B細胞免疫応答における鉄代謝制御と機能の解明
2019 - 2022 Elucidation of diverse response mechanisms of activated B cells by single cell analysis
2016 - 2019 Analysis of Bach2 expression level-dependent regulation of B cell immune response
2013 - 2016 Analysis of regulatory process of plasma cell differentiation by gene regulatory networks
2012 - 2015 Regulation of Bach2 intrinsically disordered region by ligand

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Papers (95)：

Keisuke Tada, Kazuki Mitsuyama, Hironari Nishizawa, Hiroki Shima, Akihiko Muto, Motoshi Wada, Daisuke Saigusa, Kazuhiko Igarashi. Cysteine Restriction Induces Ferroptosis Depending on the S-adenosylmethionine and Polyamine Biosynthetic Pathways in Hepatic Cancer Cells. Gastro Hep Advances. 2026. 5. 2. 100817-100817
Miki Watanabe-Matsui, Shun Kadoya, Kei Segawa, Hiroki Shima, Tadashi Nakagawa, Yuko Nagasawa, Shuichiro Hayashi, Mitsuyo Matsumoto, Mariko Ikeda, Akihiko Muto, et al. Heme regulates protein interactions and phosphorylation of BACH2 intrinsically disordered region in humoral response. iScience. 2025. 28. 1. 111529-111529
Takeshi Kurasawa, Akihiko Muto, Mitsuyo Matsumoto, Kyoko Ochiai, Kazutaka Murayama, Kazuhiko Igarashi. Absolute quantification of BACH1 and BACH2 transcription factors in B and plasma cells reveals their dynamic changes and unique roles. The Journal of Biochemistry. 2024. 176. 6. 449-459
Liang Liu, Mitsuyo Matsumoto, Miki Watanabe-Matsui, Tadashi Nakagawa, Yuko Nagasawa, Jingyao Pang, Bert K K Callens, Akihiko Muto, Kyoko Ochiai, Hirotaka Takekawa, et al. TANK Binding Kinase 1 Promotes BACH1 Degradation through Both Phosphorylation-Dependent and -Independent Mechanisms without Relying on Heme and FBXO22. International journal of molecular sciences. 2024. 25. 8
Masatoshi Ikeda, Hiroki Kato, Hiroki Shima, Mitsuyo Matsumoto, Eijiro Furukawa, Yan Yan, Ruiqi Liao, Jian Xu, Akihiko Muto, Tohru Fujiwara, et al. Heme-dependent induction of mitophagy program during differentiation of murine erythroid cells. Experimental hematology. 2022. 118. 21-30

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MISC (50)：

新堀哲也, 永井康貴, 武藤哲彦, 林慶和, 阿部太紀, 五十嵐和彦, 青木洋子. Mutation related to MECOM-associated syndrome reduces hematopoietic stem and progenitor cells in mice. 日本小児科学会雑誌. 2024. 128. 2
倉澤岳志, 武藤哲彦, 松本光代, 落合恭子, 村山和隆, 五十嵐和彦, 五十嵐和彦. B細胞におけるBACH転写因子のタンパク質量比による転写調節機構の解明. 日本生化学会大会(Web). 2023. 96th
倉澤岳志, 武藤哲彦, 松本光代, 松本光代, 落合恭子, 五十嵐和彦, 五十嵐和彦. Regulatory mechanisms of iron metabolism in B cell immune responses by the transcription factor BACH2. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
加藤浩貴, 加藤浩貴, 加藤浩貴, NGUYEN Long, 石井悠翔, 石井悠翔, 松本光代, 三枝大輔, 舟山亮, 岡江寛明, et al. Methionine metabolism controls erythropoiesis by epigenetic regulation. 日本血液学会学術集会抄録(Web). 2021. 83rd
The roles of Bach2 in B cell development and response. 2017. 68. 2. 121-128

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Lectures and oral presentations (11)：

The repression of plasma cell differentiation by Bach2 allows activated B cells to excute class switch recombination
(ESF-JSPS Frontier Science Conference for Young Researchers Cutting Edge Immunology and its Clinical Application 2011)
The repression of plasma cell differentiation by Bach2 allows activated B cells to execute class switch recombination
(Tohoku University GlobalCOE for conquest of Signla Transduction Diseases with “Network Medicine” International Minisymposium 2011)
Structure and dynamics of the B cell gene regulatory network that balances antibody class switch and plasma cell differentiation
(14th International Congress of Immunology 2010)
Bach2 is required for B-1 B cell develpoment
(第32回日本分子生物学会年会 2009)
転写因子Bach2をハブとする活性酸素シグナル-遺伝子ネットワーク共役機構の解明
(活性酸素のシグナル伝達機能第4回班会議 2009)

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Professional career (1)：

博士(医学) (筑波大学)

Work history (2)：

2011/04 - 現在東北大学准教授
2009/08 - 2011/03 東北大学講師

Awards (1)：

2009/05/16 - 財団法人艮陵医学振興会匂坂記念賞転写因子Bach2によるBリンパ球分化制御機構の解明

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