Tsuchiya Hiroyuki

ツチヤヒロユキ | Tsuchiya Hiroyuki

Affiliation and department：
Job title： Associate Professor

Research field (3)： Gastroenterology , Pharmacology , Pharmaceuticals - health and biochemistry

Research keywords (7)： nuclear receptors , hepatocellular carcinoma , HBV , insulin resistance , NAFLD/NASH , hepatocarcinogenesis , retinoids

Research theme for competitive and other funds (15)：

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Papers (80)：

Shotaro Hoi, Hiroyuki Tsuchiya, Noriko Itaba, Kyosuke Suzuki, Hiroyuki Oka, Minoru Morimoto, Tomoaki Takata, Hajime Isomoto, Goshi Shiota. WNT/β-catenin signal inhibitor IC-2-derived small-molecule compounds suppress TGF-β1-induced fibrogenic response of renal epithelial cells by inhibiting SMAD2/3 signaling. Clin Exp Pharmacol Physiol. 2020
Hiroyuki Tsuchiya, Masataka Amisaki, Ai Takenaga, Soichiro Honjo, Yoshiyuki Fujiwara, Goshi Shiota. HBx and c-MYC Cooperate to Induce URI1 Expression in HBV-Related Hepatocellular Carcinoma. Int J Mol Sci. 2019. 20. 22. 5714
Ryoma Asai, Hiroyuki Tsuchiya, Masataka Amisaki, Kazuki Makimoto, Ai Takenaga, Tomohiko Sakabe, Shotaro Hoi, Shigemi Koyama, Goshi Shiota. CD44 standard isoform is involved in maintenance of cancer stem cells of a hepatocellular carcinoma cell line. Cancer Med. 2019. 8. 2. 773-782
Masataka Amisaki, Hiroyuki Tsuchiya, Tomohiko Sakabe, Yoshiyuki Fujiwara, Goshi Shiota. Identification of genes involved in the regulation of Telomerase Reverse Transcriptase in hepatocellular carcinoma. Cancer Sci. 2019. 110. 2. 550-560
Tetsuya Suzuki, Yusuke Wakao, Tadashi Watanabe, Mika Hori, Yoshito Ikeda, Hiroyuki Tsuchiya, Kentaro Kogure, Mariko Harada-Shiba, Masahiro Fujimuro, Hiroyuki Kamiya. No enhancing effects of plasmid-specific histone acetyltransferase recruitment system on transgene expression in vivo. Nucleosides, nucleotides & nucleic acids. 2019. 38. 12. 942-949

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MISC (23)：

Zhihong Yang, Hiroyuki Tsuchiya, Sangmin Lee, Yuxia Zhang, Li Wang. Nuclear receptor Rev-Erba functions as a transcriptional activator of Chop to control SHP mediated alcoholic fatty liver. HEPATOLOGY. 2015. 62. 866A-867A
Sang Min Lee, Yuxia Zhang, Hiroyuki Tsuchiya, Rana Smalling, Anton Jetten, Li Wang. Circadian clock control of hepatic metabolism via nuclear receptor SHP. FASEB JOURNAL. 2014. 28. 1
Hiroyuki Tsuchiya, Yuxia Zhang, Sangmin Lee, Rana Smalling, Li Wang. Circadian clock mediates ER stress signaling in alcoholic fatty liver. FASEB JOURNAL. 2014. 28. 1
Hiroyuki Tsuchiya, Yuxia Zhang, Sangmin Lee, Rana Smalling, Li Wang. Nuclear receptor SHP is a key regulator of circadian clock mediated hyperhomocysteinemia induced by alcohol. HEPATOLOGY. 2014. 60. 786A-786A
Yuxia Zhang, Hiroyuki Tsuchiya, Olivier Barbier, Rana Smalling, James Cox, Don Delker, Curt H. Hagedorn, Li Wang. Long non-coding (Lnc) RNA H19 is a critical modulator of bile acid homeostasis. HEPATOLOGY. 2014. 60. 768A-768A

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Patents (6)：

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Education (3)：

Professional career (1)：

Work history (5)：

2016/08 - 現在 Graduate School of Medicine, Tottori University Division of Molecular and Genetic Medicine Associate Professor
2014/10 - 2016/07 Graduate School of Pharmaceutical Sciences, Osaka University Specially Appointed Assistant Professor
2012/12 - 2014/09 Huntsman Cancer Institute, University of Utah School of Medicine Departments of Medicine and Oncological Sciences Research Scholar
2010/04 - 2012/11 Kyoto Pharmaceutical University Department of Biophysical Chemistry Lecturer
2005/04 - 2010/03 Graduate School of Medicine, Tottori University Division of Molecular and Genetic Medicine, Department of Genetic Medicine and Regenerative Therapeutics Assistant Professor

Committee career (4)：

2019/06 - 現在 Scientific Reports Editorial Board Member
2019/01 - 現在 European Journal of Pharmacology Editorial Board Member
2018/12 - 現在 Cancers - Special Issue "Liver Cancer and Potential Therapeutic Targets" Guest Editor
2020/07 - 2021/02 Genes - Special Issue "Development of New Treatment by Identifying and Targeting Pathogenic Abnormalities of Genes" Guest Editor

Awards (6)：

2014 - American Physiological Society Poster Award (Experimental Biology 2014, GI & Liver Trainee Poster Symposium) Circadian clock mediates ER stress signaling in alcoholic fatty liver.
2011 - ビタミンE研究会奨励賞ビタミンEの脂肪細胞における脂肪蓄積促進作用
2011 - 日本薬学会近畿支部奨励賞レチノイドシグナルを介したレプチン依存的インスリン抵抗性改善メカニズムの解析
2011 - 日本レチノイド研究会武藤賞レチノイドによるレプチン依存的インスリン抵抗性改善作用メカニズムの解明
2009 - The Japan Society of Hepatology AJINOMOTO Award

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