Rchr
J-GLOBAL ID:200901051785551291   Update date: Sep. 01, 2020

Tsuchiya Hiroyuki

ツチヤ ヒロユキ | Tsuchiya Hiroyuki
Affiliation and department:
Job title: Associate Professor
Research field  (3): Gastroenterology ,  Pharmacology ,  Pharmaceuticals - health and biochemistry
Research keywords  (7): nuclear receptors ,  hepatocellular carcinoma ,  HBV ,  insulin resistance ,  NAFLD/NASH ,  hepatocarcinogenesis ,  retinoids
Research theme for competitive and other funds  (15):
  • 2018 - 2019 肝癌を抑制する、核内受容体による新たな遺伝子発現制御システムの解明
  • 2016 - 2019 レチノイドによる新たな発現制御メカニズムを介した肝癌抑制作用の解明
  • 2016 - 2017 脂肪肝におけるエピジェネティック制御機構の解明
  • 2015 - 2016 レチノイドによる新規薬理効果を介したNASH治療法の開発
  • 2013 - 2015 糖尿病に伴う脂質代謝異常における核内受容体SHPの機能解明
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Papers (80):
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MISC (23):
  • Zhihong Yang, Hiroyuki Tsuchiya, Sangmin Lee, Yuxia Zhang, Li Wang. Nuclear receptor Rev-Erba functions as a transcriptional activator of Chop to control SHP mediated alcoholic fatty liver. HEPATOLOGY. 2015. 62. 866A-867A
  • Sang Min Lee, Yuxia Zhang, Hiroyuki Tsuchiya, Rana Smalling, Anton Jetten, Li Wang. Circadian clock control of hepatic metabolism via nuclear receptor SHP. FASEB JOURNAL. 2014. 28. 1
  • Hiroyuki Tsuchiya, Yuxia Zhang, Sangmin Lee, Rana Smalling, Li Wang. Circadian clock mediates ER stress signaling in alcoholic fatty liver. FASEB JOURNAL. 2014. 28. 1
  • Hiroyuki Tsuchiya, Yuxia Zhang, Sangmin Lee, Rana Smalling, Li Wang. Nuclear receptor SHP is a key regulator of circadian clock mediated hyperhomocysteinemia induced by alcohol. HEPATOLOGY. 2014. 60. 786A-786A
  • Yuxia Zhang, Hiroyuki Tsuchiya, Olivier Barbier, Rana Smalling, James Cox, Don Delker, Curt H. Hagedorn, Li Wang. Long non-coding (Lnc) RNA H19 is a critical modulator of bile acid homeostasis. HEPATOLOGY. 2014. 60. 768A-768A
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Patents (6):
  • レチノイン酸受容体リガンドの抗腫瘍作用、発癌抑制作用を含めた種々の作用を決定する遺伝子の同定
  • レチノイン酸受容体リガンドによるインスリン抵抗性改善作用
  • 核酸構築物及びそれを利用した標的領域への変異導入法
  • 免疫活性増強剤とこれを用いた免疫活性の増強方法
  • DNA配列の塩基変換方法
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Education (3):
  • 2002 - 2005 Hokkaido University
  • 2000 - 2002 Hokkaido University
  • 1996 - 2000 Hokkaido University
Professional career (1):
  • Ph.D. (Hokkaido Univ.)
Work history (5):
  • 2016/08 - 現在 Graduate School of Medicine, Tottori University Division of Molecular and Genetic Medicine Associate Professor
  • 2014/10 - 2016/07 Graduate School of Pharmaceutical Sciences, Osaka University Specially Appointed Assistant Professor
  • 2012/12 - 2014/09 Huntsman Cancer Institute, University of Utah School of Medicine Departments of Medicine and Oncological Sciences Research Scholar
  • 2010/04 - 2012/11 Kyoto Pharmaceutical University Department of Biophysical Chemistry Lecturer
  • 2005/04 - 2010/03 Graduate School of Medicine, Tottori University Division of Molecular and Genetic Medicine, Department of Genetic Medicine and Regenerative Therapeutics Assistant Professor
Committee career (4):
  • 2019/06 - 現在 Scientific Reports Editorial Board Member
  • 2019/01 - 現在 European Journal of Pharmacology Editorial Board Member
  • 2018/12 - 現在 Cancers - Special Issue "Liver Cancer and Potential Therapeutic Targets" Guest Editor
  • 2020/07 - 2021/02 Genes - Special Issue "Development of New Treatment by Identifying and Targeting Pathogenic Abnormalities of Genes" Guest Editor
Awards (6):
  • 2014 - American Physiological Society Poster Award (Experimental Biology 2014, GI & Liver Trainee Poster Symposium) Circadian clock mediates ER stress signaling in alcoholic fatty liver.
  • 2011 - ビタミンE研究会 奨励賞 ビタミンEの脂肪細胞における脂肪蓄積促進作用
  • 2011 - 日本薬学会近畿支部 奨励賞 レチノイドシグナルを介したレプチン依存的インスリン抵抗性改善メカニズムの解析
  • 2011 - 日本レチノイド研究会 武藤賞 レチノイドによるレプチン依存的インスリン抵抗性改善作用メカニズムの解明
  • 2009 - The Japan Society of Hepatology AJINOMOTO Award
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