Research theme for competitive and other funds (32):
2023 - 2025 光制御可能な相分離顆粒デバイスの開発
2022 - 2024 Photochemical internalization of mRNAs
2018 - 2022 Creation of mammalian oocytes with high fertility by spatiotemporal regulation of the function of mitochondria
2018 - 2022 生命機能の光制御のための機能性光増感ペプチドの開発
2017 - 2019 ケージドアミノアシルtRNAによる初期胚における翻訳の時空間的制御
2016 - 2019 Live imaging of microRNA by intracellular-invasion peptide nucleic acid beacon
2015 - 2017 細胞内におけるRNA分解の観測法の開発とストレス応答研究への応用
2014 - 2016 光増感剤修飾分子を用いたPCI の分子科学
2013 - 2016 PCDR技術による細胞機能の光制御
2013 - 2015 Sonochemical internalization法の確立
2012 - 2014 光増感によるエンドソーム脱出の分子科学
2011 - 2013 Analyses of cell-cycle dependency of intracellular events induced by RNAs
2009 - 2012 Development of CLIP-RNAi method
2010 - 2011 乳酸菌をキャリアとしたRNAiデリバリー
2008 - 2010 拡張型蛋白質合成系を含む細胞システムの構築
2008 - 2010 RNAi創薬を目指したRNAデリバリー技術の開発
2007 - 2009 New development in study of mitochondrial translation system of theparasitic nematode
2007 - 2009 人工核酸によるRNAの検出と精製
2006 - 2008 RNAの新規細胞内導入法の開発と応用
2007 - 2008 多様な非天然アミノ酸が導入可能なタンパク質合成系の創製
2006 - 2008 非天然アミノ酸含有タンパク質の無細胞及び細胞モデル系での発現
2003 - 2008 Chemical Expansion of the Central Dogma towards Synthetic Microorganisms
2006 - 2007 miRNA発現量解析のためのペプチド核酸アレイの開発
2005 - 2007 Study of parasite mitochondrial translation system which have truncated functional RNAs
2005 - 2007 生細胞中での蛋白質の部位特異的蛍光標識法の開発
2005 - 2006 リン酸化セリンを含む蛋白質作製法の開発
2003 - 2005 Study of nematode mitochondrial translation system using parasitic nematodes
2002 - 2004 Elucidation of basic principle in genetic information translation system by using the specialty of animal mitochondria
2002 - 2003 異常tRNAを用いた翻訳系
2001 - 2002 伸長因子EF-TuによるTアームを欠くtRNAの認識機構
1999 - 2002 Elucidation of the construction principle of the mitochondria translation system by means of structural biology
1998 - 1998 NMRによるミトコンドリアtRNAの立体構造解析
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Papers (101):
Shengli Zhou, Fuka Nishimura, Kazuhaya Wada, Kaho Fujii, Takeshi Kondo, Kazunori Watanabe, Yoshitane Imai, Takashi Ohtsuki, Mizuki Kitamatsu. Configuration of two cysteine residues in a ring within a stapled Bim peptide affects the secondary structure and apoptotic activity. Bioorganic & Medicinal Chemistry Letters. 2024. 112. 129915-129915
Shengli Zhou, Kaname Tsutsumiuchi, Ritsuko Imai, Yukiko Miki, Anna Kondo, Hiroshi Nakagawa, Kazunori Watanabe, Takashi Ohtsuki. In Vitro Study of Tumor-Homing Peptide-Modified Magnetic Nanoparticles for Magnetic Hyperthermia. Molecules. 2024. 29. 11. 2632-2632
Yuhi Maekawa, Sora Sakura, Yuji Furutani, Rento Fujihara, Hisashi Sugime, Takashi Ohtsuki, Mizuki Kitamatsu. Pyrene-Modified Cyclic Peptides Detect Cu2+ Ions by Fluorescence in Water. Processes. 2024. 12. 4. 746-746
Taufik F.N. Hakim, Kazunori Watanabe, Shomu Fujimoto, Mizuki Kitamatsu, Takashi Ohtsuki. Self-assembly of Peptide Amphiphiles with Alkyl Groups for siRNA Delivery. Chemistry Letters. 2023
Yuka Ikawa, Takuya Wakai, Hiroaki Funahashi, Tet Htut Soe, Kazunori Watanabe, Takashi Ohtsuki. Photo-dependent cytosolic delivery of shRNA into a single blastomere in a mouse embryo. Scientific reports. 2023. 13. 1. 13050-13050
杉原桃香, 大槻高史, 渡邉和則. Development of photothermal therapy agents that added tumor specificity and improved apoptosis induction efficiency. 日本バイオマテリアル学会大会予稿集(Web). 2023. 45th
渡邉 和則, 大槻 高史. 光応答的なRNAデリバリー(特集 mRNA医薬・mRNAワクチンの新展開). Drug delivery system / 日本DDS学会 編. 2022. 37. 3. 229-236
Cell-penetrating peptide/photosensitizer conjugates for photo-triggered cytosolic delivery of RNAs and peptides
(18th International Congress on Photobiology 2024)
Development of the analyzing method for single nucleotide-mutated single-cancer cells using Peptide Nucleic acid Probes and Single-Cell Microarray
(日本化学会春季年会講演予稿集(Web) 2024)
RNA encapsulation and photo-responsive release by caged coacervates based on liquid-liquid phase separation
(日本化学会春季年会講演予稿集(Web) 2024)