Rchr
J-GLOBAL ID：200901051903592933
Update date: Apr. 16, 2025
Higaki Kazutaka
ヒガキ カズタカ | Higaki Kazutaka
Affiliation and department：
Job title：
Professor
Homepage URL (1)：
http://www.pharm.okayama-u.ac.jp/doc/lob/yakuzai/index.html
Research field (3)：
Clinical pharmacy
, Pharmacology
, Pharmaceuticals - health and biochemistry
Research keywords (2)：
生物薬剤学
, Biopharmaceutics
Research theme for competitive and other funds (19)：
- 2020 - 2025 Effect of ENS dysfunction on drug absorption from small intestine
- 2020 - 2023 Establishment of a novel drug delivery system for targeting cancer stem cells based on the structual analysis of tumor blood vesseles.
- 2019 - 2022 Elucidation of liver mitochondrial failure and autoinflammation with RNA-epigenetics caused by nutrient stress
- 2018 - 2021 Development of novel DDS technology for effective treatment of refractory cancer
- 2017 - 2020 Analysis of changes in intestinal drug absorption behavior caused by metabolic disorder of serotonin
- 2015 - 2018 Establishment of novel strategy in cancer treatments based on normalization of tumor vasculatures
- 2014 - 2017 Analysis of drug absorption behavior under gastrointestintestinal diseases related with abnormal metabolism of serotonin
- 2012 - 2015 Establishment of novel strategy in cancer treatments based on modulation of microenvironment of tumor tissues
- 2011 - 2013 Analysis of drug absorption behavior in the enteric nervous system-related gastrointestinal diseases
- 2009 - 2011 Analysis of dissolution kinetics and first-pass elimination of orally administered drugs and its application to prediction of absorption behavior after oral administration
- 2008 - 2010 Systematic analysis of ENS-regulation of drug absorption
- 2007 - 2008 Analysis of first-pass effect in small intestinal mucosa and its application to prediction of drug absorption behavior after oral administration
- 2006 - 2007 Regulation of drug absorption by enteric nervous system: Studies on drug secretion via specialized mechanisms.
- 2005 - 2006 Analysis of physiological factors regulating oral absorption behaviors of drugs and its application to prediction of plasma concentration-time profile
- 2004 - 2005 Regulation of drug absorption and secretion from gastrointestinal via specialized mechanisms by enteric nervous system
- 2003 - 2004 Analysis of Drug Permeation Mechanism across Oral Mucosa Using Cultured Stratified Cell Layers
- 2000 - 2001 Regulation of drug absorption from gastrointestinal tract by enteric nerve system
- 1998 - 1999 Analysis of Carrier-Mediated Transport Systems in Drug Absorption from Oral Mucosa
- 1997 - 1998 Effect of neurohumoral control on gastrointestinal absorption of drugs
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Papers (183)：
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Masato Maruyama, Reiya Torii, Hazuki Matsui, Hiroki Hayashi, Ken-ichi Ogawara, Kazutaka Higaki. Repeated sequential administration of pegylated emulsion of SU5416 and liposomal paclitaxel enhances anti-tumor effect in 4T1 breast cancer-bearing mice. European Journal of Pharmaceutics and Biopharmaceutics. 2025. 209. 114663-114663
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Saki Nishiyama, Yuki Takemoto, Keita Yamanouchi, Keiji Kondo, Sho Kawatsu, Masato Maruyama, Kazutaka Higaki. Dynamic changes in the distribution equilibrium of drugs in microemulsions associated with drug absorption facilitate the absorption improvement for drugs with low water-solubility by self-microemulsifying drug delivery system (SMEDDS). International Journal of Pharmaceutics. 2025. 125458-125458
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Masato Maruyama, Tomoki Ueda, Yusuke Ienaka, Haruka Tojo, Kenji Hyodo, Ken-ichi Ogawara, Kazutaka Higaki. EGF-induced P-gp expression in tumor vasculature contributes to therapeutic resistance to Doxorubicin-PEG-liposomes in mice bearing Doxorubicin-resistant B16-BL6 tumors. Journal of Drug Delivery Science and Technology. 2025. 106. 106690-106690
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Ryosuke Tatsuta, Akiko Tanaka, Ken-ichi Ogawara, Kazutaka Higaki, Tomoyuki Furubayashi, Toshiyasu Sakane. In vivo systemic evaluation of nasal drug absorption from powder formulations in rats. European Journal of Pharmaceutics and Biopharmaceutics. 2024. 207. 114612-114612
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Shohei Aikawa, Hironori Tanaka, Hiroshi Ueda, Masato Maruyama, Kazutaka Higaki. Specific intermolecular interaction with sodium glycocholate generates the co-amorphous system showing higher physical stability and aqueous solubility of Y5 receptor antagonist of neuropeptide Y, a brick dust molecule. European Journal of Pharmaceutics and Biopharmaceutics. 2024. 202. 114395-114395
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MISC (60)：
Patents (1)：
Books (15)：
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ゲノム創薬科学
裳華房 2017
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薬剤学 (第5版 2刷)
廣川書店 2016
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薬剤学概史:III各論 岡山大学薬学部 消化管吸収の本流を継承
日本薬剤学会 2015
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非経口投与製剤の開発と応用-次世代型医薬品の新規投与形態の開拓を目指して:第14章 注射による薬物投与と新規注射剤の開発 1. ナノDDS製剤を用いたがん治療の最適化
シーエムシー出版 2013
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難吸収性薬物の吸収性改善と新規投与製剤の開発:第2章 製剤添加物による難吸収性薬物の経口ならびに経粘膜吸収性の改善 2. 吸収促進剤ならびに粘膜障害防御剤を用いた難吸収性薬物の有効かつ安全性の高い経粘膜デリバリーの開発
シーエムシー出版 2012
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Lectures and oral presentations (272)：
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血管新生阻害剤SU-5416による血管正常化療法ががん関連繊維芽細胞に及ぼす影響
(第38回日本DDS学会 2022)
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マウス乳がん由来4T1細胞におけるがん幹細胞様のモデル細胞株樹立に関する研究
(第38回日本DDS学会 2022)
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血管新生阻害剤 SU5416 - パクリタキセル (PTX) 内封 PEG リポソームの逐次的頻回併用療法の転移性乳がん4T1担がんマウスにおける抗腫瘍効果
(日本薬剤学会第37年会 2022)
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ドキソルビシン(DOX)耐性腫瘍に対するDOX-PEGリポソームの抗腫瘍効果に及ぼす腫瘍組織内血管内皮細胞特性の影響
(日本薬剤学会第37年会 2022)
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難水溶性薬物ClofazimineのSelf-nanoemulsifying Drug Delivery System (SNEDDS)による経口吸収挙動改善機構の解析
(日本薬剤学会第37年会 2022)
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Professional career (1)：
Committee career (15)：
- 2014 - 現在 日本薬学会 代議員
- 2013 - 現在 ジェネリック医薬品品質問題検討会 委員
- 2009 - 現在 日本DDS学会 評議員
- 2008 - 現在 日本薬物動態学会 評議員
- 2005 - 現在 日本薬剤学会 評議員
- 2009 - 創剤フォーラム シンポジウム 座長
- 2009 - 日本薬学会 中四国支部大会 座長
- 2006 - 2007 日本薬物動態学会 評議員
- 2004 - 2005 日本薬物動態学会 評議員
- 2003 - 2004 日本薬剤学会 評議員
- 2002 - 2003 日本薬物動態学会 評議員
- 2002 - 2003 生物薬剤学研究会 世話人
- 2001 - 2002 日本薬剤学会 評議員
- 2000 - 2001 日本薬物動態学会 評議員
- 1998 - 1999 日本薬物動態学会 評議員
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Association Membership(s) (8)：
生物薬剤学研究会
, Controlled Release Society
, 創剤フォーラム
, 米国薬学会
, 日本DDS学会
, 日本薬剤学会
, 日本薬物動態学会
, 日本薬学会
