Higaki Kazutaka

ヒガキカズタカ | Higaki Kazutaka

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.pharm.okayama-u.ac.jp/doc/lob/yakuzai/index.html

Research field (3)： Clinical pharmacy , Pharmacology , Pharmaceuticals - health and biochemistry

Research keywords (2)：生物薬剤学 , Biopharmaceutics

Research theme for competitive and other funds (19)：

2020 - 2025 Effect of ENS dysfunction on drug absorption from small intestine
2020 - 2023 Establishment of a novel drug delivery system for targeting cancer stem cells based on the structual analysis of tumor blood vesseles.
2019 - 2022 Elucidation of liver mitochondrial failure and autoinflammation with RNA-epigenetics caused by nutrient stress
2018 - 2021 Development of novel DDS technology for effective treatment of refractory cancer
2017 - 2020 Analysis of changes in intestinal drug absorption behavior caused by metabolic disorder of serotonin

2015 - 2018 Establishment of novel strategy in cancer treatments based on normalization of tumor vasculatures

2014 - 2017 Analysis of drug absorption behavior under gastrointestintestinal diseases related with abnormal metabolism of serotonin

2012 - 2015 Establishment of novel strategy in cancer treatments based on modulation of microenvironment of tumor tissues

2011 - 2013 Analysis of drug absorption behavior in the enteric nervous system-related gastrointestinal diseases

2009 - 2011 Analysis of dissolution kinetics and first-pass elimination of orally administered drugs and its application to prediction of absorption behavior after oral administration

2008 - 2010 Systematic analysis of ENS-regulation of drug absorption

2007 - 2008 Analysis of first-pass effect in small intestinal mucosa and its application to prediction of drug absorption behavior after oral administration

2006 - 2007 Regulation of drug absorption by enteric nervous system: Studies on drug secretion via specialized mechanisms.

2005 - 2006 Analysis of physiological factors regulating oral absorption behaviors of drugs and its application to prediction of plasma concentration-time profile

2004 - 2005 Regulation of drug absorption and secretion from gastrointestinal via specialized mechanisms by enteric nervous system

2003 - 2004 Analysis of Drug Permeation Mechanism across Oral Mucosa Using Cultured Stratified Cell Layers

2000 - 2001 Regulation of drug absorption from gastrointestinal tract by enteric nerve system

1998 - 1999 Analysis of Carrier-Mediated Transport Systems in Drug Absorption from Oral Mucosa

1997 - 1998 Effect of neurohumoral control on gastrointestinal absorption of drugs

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Papers (179)：

Shohei Aikawa, Hironori Tanaka, Hiroshi Ueda, Masato Maruyama, Kazutaka Higaki. Specific intermolecular interaction with sodium glycocholate generates the co-amorphous system showing higher physical stability and aqueous solubility of Y5 receptor antagonist of neuropeptide Y, a brick dust molecule. European Journal of Pharmaceutics and Biopharmaceutics. 2024. 202. 114395-114395
Tomoya Inoue, Seito Maehara, Masato Maruyama, Kazutaka Higaki. Combination of co-amorphization with SNEDDS outperforms Ofev® in the oral absorption of nintedanib. International Journal of Pharmaceutics. 2024. 657. 124197-124197
Hironori Mukai, Masashi Takanashi, Ken-ichi Ogawara, Masato Maruyama, Kazutaka Higaki. Possible Regulation of P-Glycoprotein Function by Adrenergic Agonists II: Study with Isolated Rat Jejunal Sheets and Caco-2 Cell monolayers. Journal of Pharmaceutical Sciences. 2024. 113. 5. 1209-1219
Masato Maruyama, Hazuki Matsui, Haruka Nakamura, Reiya Torii, Yuta Takasugi, Ken-ichi Ogawara, Kazutaka Higaki. Vascular normalization with pegylated emulsion of SU5416 enhances anti-tumor effect of liposomal paclitaxel in 4T1 breast cancer-bearing mice: Analysis of intratumoral vessels and microenvironment. Journal of Drug Delivery Science and Technology. 2024. 96. 105647
Masato Gomi, Naoya Mizutani, Ryotaro Senoo, Noriaki Matsubara, Ayahisa Watanabe, Masato Maruyama, Go Kimura, Kazutaka Higaki. Development of Sustained Release System Based on High Water-Absorbable Gel Formation Using Croscarmellose Sodium, Alkaline Excipients and HPMC (ACSH SR System); Novel Application of Croscarmellose Sodium as a Gel Former. Pharmaceutical Research. 2023. 40. 12. 3073-3086

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MISC (60)：

Study on Ultrasonic Emulsification Condition using Microchannel Device. 2017. 117. 155. 37-40
Effect of Pre-emulsion in Generation Nano-emulsion by Using Ultrasonic Vibration Device. 2016. 33. 1-4
Relationship of applied voltage and droplet diameter in ultrasonic vibration device for generation of nano-emulsion. 2015. 32. 1-4
トピック薬学部をめぐる状況-岡山大学薬学科·創薬科学科および大学院. Journal of Japanese Cosmetic Science Society. 2012. 36. 4. 333-334
神田岳文, 富永宜幸, 原田拓也, 鈴森康一, 小野努, 岩渕草太郎, 伊東一行, 大河原賢一, 檜垣和孝, 吉澤雄太. 積層型超音波振動マイクロ流路デバイスによるエマルション生成. 精密工学会大会学術講演会講演論文集. 2011. 2011. ROMBUNNO.M18

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Patents (1)：

超微小液滴調製装置

Books (15)：

ゲノム創薬科学
裳華房 2017
薬剤学 (第5版 2刷)
廣川書店 2016
薬剤学概史:III各論岡山大学薬学部消化管吸収の本流を継承
日本薬剤学会 2015
非経口投与製剤の開発と応用-次世代型医薬品の新規投与形態の開拓を目指して:第14章注射による薬物投与と新規注射剤の開発 1. ナノDDS製剤を用いたがん治療の最適化
シーエムシー出版 2013
難吸収性薬物の吸収性改善と新規投与製剤の開発:第2章製剤添加物による難吸収性薬物の経口ならびに経粘膜吸収性の改善 2. 吸収促進剤ならびに粘膜障害防御剤を用いた難吸収性薬物の有効かつ安全性の高い経粘膜デリバリーの開発
シーエムシー出版 2012

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Lectures and oral presentations (272)：

血管新生阻害剤SU-5416による血管正常化療法ががん関連繊維芽細胞に及ぼす影響
(第38回日本DDS学会 2022)
マウス乳がん由来4T1細胞におけるがん幹細胞様のモデル細胞株樹立に関する研究
(第38回日本DDS学会 2022)
血管新生阻害剤 SU5416 - パクリタキセル (PTX) 内封 PEG リポソームの逐次的頻回併用療法の転移性乳がん4T1担がんマウスにおける抗腫瘍効果
(日本薬剤学会第37年会 2022)
ドキソルビシン(DOX)耐性腫瘍に対するDOX-PEGリポソームの抗腫瘍効果に及ぼす腫瘍組織内血管内皮細胞特性の影響
(日本薬剤学会第37年会 2022)
難水溶性薬物ClofazimineのSelf-nanoemulsifying Drug Delivery System (SNEDDS)による経口吸収挙動改善機構の解析
(日本薬剤学会第37年会 2022)

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Professional career (1)：

博士(薬学) (京都大学)

Committee career (15)：

2014 - 現在日本薬学会代議員
2013 - 現在ジェネリック医薬品品質問題検討会委員
2009 - 現在日本DDS学会評議員
2008 - 現在日本薬物動態学会評議員
2005 - 現在日本薬剤学会評議員

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Association Membership(s) (8)：

生物薬剤学研究会 , Controlled Release Society , 創剤フォーラム , 米国薬学会 , 日本DDS学会 , 日本薬剤学会 , 日本薬物動態学会 , 日本薬学会

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